Chromosomal damage in occupationally exposed health
professionals assessed by two cytogenetic methods

J 2022

Chromosomal damage in occupationally exposed health professionals assessed by two cytogenetic methods

KADLČÍKOVÁ, Dita; Petra MUSILOVÁ; Hana HRADSKÁ; Miluše VOZDOVÁ; Markéta PETROVOVÁ et al.

Základní údaje

Originální název

Chromosomal damage in occupationally exposed health professionals assessed by two cytogenetic methods

Autoři

KADLČÍKOVÁ, Dita; Petra MUSILOVÁ; Hana HRADSKÁ; Miluše VOZDOVÁ; Markéta PETROVOVÁ; Marek SVOBODA a Jiří RUBEŠ

Vydání

ARCHIVES OF ENVIRONMENTAL & OCCUPATIONAL HEALTH, UNITED STATES, ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD, 2022, 1933-8244

Další údaje

Typ výsledku

Článek v odborném periodiku

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 1.800

Označené pro přenos do RIV

DOI

https://doi.org/10.1080/19338244.2022.2118213

Štítky

RIV ne

Změněno: 31. 10. 2022 09:30, MUDr. Markéta Petrovová, Ph.D.

Anotace

V originále

The study assessed occupationally induced chromosomal damage in hospital personnel at risk of exposure to antineoplastic drugs and/or low doses of ionizing radiation by two cytogenetic methods. Cultured peripheral blood lymphocytes of eighty-five hospital workers were examined twice over 2 to 3 years by classical chromosomal aberration analysis and fluorescence in situ hybridization. The comparison of the 1st and the 2nd sampling of hospital workers showed a significant increase in chromatid and chromosomal aberrations (all p < .05) examined by classical chromosomal aberration analysis, and in unstable aberrations (all p < .05) detected by fluorescence in situ hybridization. Both cytogenetic methods were able to detect an increase of unstable aberrations in the 2nd sampling. The raised frequency of unstable cytogenetic parameters suggested higher recent exposure to genotoxic agents.

Citovat

KADLČÍKOVÁ, Dita; Petra MUSILOVÁ; Hana HRADSKÁ; Miluše VOZDOVÁ; Markéta PETROVOVÁ; Marek SVOBODA a Jiří RUBEŠ. Chromosomal damage in occupationally exposed health professionals assessed by two cytogenetic methods. ARCHIVES OF ENVIRONMENTAL & OCCUPATIONAL HEALTH. UNITED STATES: ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD, 2022, roč. 2022. ISSN 1933-8244. Dostupné z: https://doi.org/10.1080/19338244.2022.2118213.

@article{2228301,
   author = {Kadlčíková, Dita and Musilová, Petra and Hradská, Hana and Vozdová, Miluše and Petrovová, Markéta and Svoboda, Marek and Rubeš, Jiří},
   article_location = {UNITED STATES},
   doi = {https://doi.org/10.1080/19338244.2022.2118213},
   issn = {1933-8244},
   journal = {ARCHIVES OF ENVIRONMENTAL & OCCUPATIONAL HEALTH},
   title = {Chromosomal damage in occupationally exposed health professionals assessed by two cytogenetic methods},
   volume = {2022},
   year = {2022}
}

TY  - JOUR
ID  - 2228301
AU  - Kadlčíková, Dita - Musilová, Petra - Hradská, Hana - Vozdová, Miluše - Petrovová, Markéta - Svoboda, Marek - Rubeš, Jiří
PY  - 2022
TI  - Chromosomal damage in occupationally exposed health professionals assessed by two cytogenetic methods
JF  - ARCHIVES OF ENVIRONMENTAL & OCCUPATIONAL HEALTH
VL  - 2022
PB  - ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
SN  - 19338244
N2  - The study assessed occupationally induced chromosomal damage in hospital personnel at risk of exposure to antineoplastic drugs and/or low doses of ionizing radiation by two cytogenetic methods. Cultured peripheral blood lymphocytes of eighty-five hospital workers were examined twice over 2 to 3 years by classical chromosomal aberration analysis and fluorescence in situ hybridization. The comparison of the 1st and the 2nd sampling of hospital workers showed a significant increase in chromatid and chromosomal aberrations (all p < .05) examined by classical chromosomal aberration analysis, and in unstable aberrations (all p < .05) detected by fluorescence in situ hybridization. Both cytogenetic methods were able to detect an increase of unstable aberrations in the 2nd sampling. The raised frequency of unstable cytogenetic parameters suggested higher recent exposure to genotoxic agents.
ER  -

KADLČÍKOVÁ, Dita; Petra MUSILOVÁ; Hana HRADSKÁ; Miluše VOZDOVÁ; Markéta PETROVOVÁ; Marek SVOBODA a Jiří RUBEŠ. Chromosomal damage in occupationally exposed health professionals assessed by two cytogenetic methods. \textit{ARCHIVES OF ENVIRONMENTAL \&{} OCCUPATIONAL HEALTH}. UNITED STATES: ROUTLEDGE JOURNALS, TAYLOR \&{} FRANCIS LTD, 2022, roč.~2022. ISSN~1933-8244. Dostupné z: https://doi.org/10.1080/19338244.2022.2118213.

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