Self-emulsifying System Incorporated in a Polymeric Carrier 
for Controlled Delivery of Thymol

k 2022

Self-emulsifying System Incorporated in a Polymeric Carrier for Controlled Delivery of Thymol

KOUTNÁ, Gabriela; Miroslava PAVELKOVÁ; Kateřina KUBOVÁ; Martina ČUBOVÁ URBANOVÁ; Jiří BRUS et al.

Základní údaje

Originální název

Self-emulsifying System Incorporated in a Polymeric Carrier for Controlled Delivery of Thymol

Autoři

KOUTNÁ, Gabriela; Miroslava PAVELKOVÁ ; Kateřina KUBOVÁ ; Martina ČUBOVÁ URBANOVÁ; Jiří BRUS; Jan MUSELÍK; Jakub VYSLOUŽIL a David VETCHÝ

Vydání

NanoMed 2022, 2022

Další údaje

Jazyk

angličtina

Typ výsledku

Prezentace na konferencích

Obor

30104 Pharmacology and pharmacy

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Kód RIV

RIV/00216224:14160/22:00127158

Organizační jednotka

Farmaceutická fakulta

Klíčová slova česky

pektin; alginát; hydrogelové částice; samoemulgující systém; thymol; řízené uvolňování léčiva; nespecifické střevní záněty

Klíčová slova anglicky

pectin; alginate; hydrogel particles; self emulsifying system; thymol; controlled release of drug; nonspecific intestinal inflammations

Štítky

rivok, ÚFT

Příznaky

Mezinárodní význam

Změněno: 2. 12. 2022 13:39, JUDr. Sabina Gajdzioková

Anotace

V originále

The biocompatibility and biodegradability of natural polymers make them an object of interest for many applications in biomedicine and pharmacy. Their ability to control drug release makes them very significant pharma-ceutical excipients for formulating dosage forms, especially particulate dosage forms. These advantages, together with encapsula-tion of natural active agents and the use of some soft method for their preparation, an "eco-friendly" drug dosage form could pro-vide. Many natural active ingredients today are experiencing a comeback. However, most of them have low solubility, leading to low bioavailability and ultimately low therapeutic efficacy. Therefore, a way of their modifica-tion and incorporation into the dosage form plays a crucial role in their therapeutic effec-tiveness. There are many methods to increase the bio-availability of poorly soluble drugs after oral administration. The formation of a self-emulsifying system (SES) ensures the dis-solving of lipophilic active substance and, after its reconstitution, the shape of o/w emulsion, which is necessary for drug ab-sorption either in the systemic circulation or inflamed mucosa. This systemic or local ef-fect depends on the drop size of the internal phase of the emulsion, whether the nanoemulsion, microemulsion, or macro-emulsion is created (1). Thus, this paper discusses a dosage form of pectin/alginate particles as a carrier of SES with dissolved monoterpene thymol. It is a drug with a wide range of biological effects (antimicrobial, antiviral, antifungal, anti-inflammatory, antioxidant, antineoplastic, etc.) with potential usage in nonspecific intes-tinal inflammations (NSZ). Nowadays, the treatment of NSZ includes mostly cortico-steroids and antibiotics administration, so that this new approach could become an alterna-tive to this treatment. Thymol's incorporation into the SES containing triacylglycerols, Labrasol®, and propylene glycol in ratio 2:7:1 and their subsequent solidification in pec-tin/alginate particles lead to the final solid drug form formation. The evaluation of the morphological parameters using optical and electron microscopes, evaluation of swelling capacity and dissolution profiles, and finally, the assessment of the formed emulsion after SES reconstitution in a phosphate buffer pH 6 are integral parts of this experiment.

Návaznosti

GA22-03187S, projekt VaV

Název: Racionální design částicových polysacharidových systémů pro přívod léčiv s širokým spekterem biologické aktivity k terapii sliznic (Akronym: 22-03187S)

Investor: Grantová agentura ČR, Racionální design částicových polysacharidových systémů pro přívod léčiv s širokým spektrem biologické aktivity k terapii sliznic

Citovat

KOUTNÁ, Gabriela; Miroslava PAVELKOVÁ; Kateřina KUBOVÁ; Martina ČUBOVÁ URBANOVÁ; Jiří BRUS; Jan MUSELÍK; Jakub VYSLOUŽIL a David VETCHÝ. Self-emulsifying System Incorporated in a Polymeric Carrier for Controlled Delivery of Thymol. In NanoMed 2022. 2022.

@proceedings{2232022,
   author = {Koutná, Gabriela and Pavelková, Miroslava and Kubová, Kateřina and Čubová Urbanová, Martina and Brus, Jiří and Muselík, Jan and Vysloužil, Jakub and Vetchý, David},
   booktitle = {NanoMed 2022},
   keywords = {pectin; alginate; hydrogel particles; self emulsifying system; thymol; controlled release of drug; nonspecific intestinal inflammations},
   language = {eng},
   title = {Self-emulsifying System Incorporated in a Polymeric Carrier for Controlled Delivery of Thymol},
   url = {https://www.setcor.org/conferences/nanomed-2022},
   year = {2022}
}

TY  - CONF
ID  - 2232022
AU  - Koutná, Gabriela - Pavelková, Miroslava - Kubová, Kateřina - Čubová Urbanová, Martina - Brus, Jiří - Muselík, Jan - Vysloužil, Jakub - Vetchý, David
PY  - 2022
TI  - Self-emulsifying System Incorporated in a Polymeric Carrier for Controlled Delivery of Thymol
KW  - pectin
KW  - alginate
KW  - hydrogel particles
KW  - self emulsifying system
KW  - thymol
KW  - controlled release of drug
KW  - nonspecific intestinal inflammations
UR  - https://www.setcor.org/conferences/nanomed-2022
N2  - The biocompatibility and biodegradability of natural polymers make them an object of interest for many applications in biomedicine and pharmacy. Their ability to control drug release makes them very significant pharma-ceutical excipients for formulating dosage forms, especially particulate dosage forms. These advantages, together with encapsula-tion of natural active agents and the use of some soft method for their preparation, an "eco-friendly" drug dosage form could pro-vide. Many natural active ingredients today are experiencing a comeback. However, most of them have low solubility, leading to low bioavailability and ultimately low therapeutic efficacy. Therefore, a way of their modifica-tion and incorporation into the dosage form plays a crucial role in their therapeutic effec-tiveness. There are many methods to increase the bio-availability of poorly soluble drugs after oral administration. The formation of a self-emulsifying system (SES) ensures the dis-solving of lipophilic active substance and, after its reconstitution, the shape of o/w emulsion, which is necessary for drug ab-sorption either in the systemic circulation or inflamed mucosa. This systemic or local ef-fect depends on the drop size of the internal phase of the emulsion, whether the nanoemulsion, microemulsion, or macro-emulsion is created (1). Thus, this paper discusses a dosage form of pectin/alginate particles as a carrier of SES with dissolved monoterpene thymol. It is a drug with a wide range of biological effects (antimicrobial, antiviral, antifungal, anti-inflammatory, antioxidant, antineoplastic, etc.) with potential usage in nonspecific intes-tinal inflammations (NSZ). Nowadays, the treatment of NSZ includes mostly cortico-steroids and antibiotics administration, so that this new approach could become an alterna-tive to this treatment. Thymol's incorporation into the SES containing triacylglycerols, Labrasol®, and propylene glycol in ratio 2:7:1 and their subsequent solidification in pec-tin/alginate particles lead to the final solid drug form formation. The evaluation of the morphological parameters using optical and electron microscopes, evaluation of swelling capacity and dissolution profiles, and finally, the assessment of the formed emulsion after SES reconstitution in a phosphate buffer pH 6 are integral parts of this experiment.
ER  -

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