J 2022

Orthohantaviruses in Reservoir and Atypical Hosts in the Czech Republic: Spillover Infection and Indication of Virus-Specific Tissue Tropism

HÖNIG, Václav; Jan KAMIŠ; Aneta MARŠÍKOVÁ; Tereza MATĚJKOVÁ; Pavel STOPKA et al.

Základní údaje

Originální název

Orthohantaviruses in Reservoir and Atypical Hosts in the Czech Republic: Spillover Infection and Indication of Virus-Specific Tissue Tropism

Autoři

HÖNIG, Václav; Jan KAMIŠ; Aneta MARŠÍKOVÁ; Tereza MATĚJKOVÁ; Pavel STOPKA; Anna MÁCOVÁ; Daniel RŮŽEK a Jana KVIČEROVÁ

Vydání

Microbiology Spectrum, American Society for Microbiology, 2022, 2165-0497

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10607 Virology

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

Impakt faktor

Impact factor: 3.700

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14310/22:00127194

Organizační jednotka

Přírodovědecká fakulta

DOI

UT WoS

EID Scopus

Klíčová slova anglicky

Kurkino virus; Tula virus; Seewis virus; Asikkala virus; rodents; Eulipotyphla; phylogeny; host specificity; tissue specificity; zoonoses; zoonosis

Štítky

Příznaky

Mezinárodní význam, Recenzováno
Změněno: 21. 11. 2022 10:29, Mgr. Marie Novosadová Šípková, DiS.

Anotace

V originále

Orthohantaviruses (genus Orthohantavirus) are a diverse group of viruses that are closely associated with their natural hosts (rodents, shrews, and moles). Several orthohantaviruses cause severe disease in humans. Central and western Europe are areas with emerging orthohantavirus occurrences. In our study, several orthohantaviruses, including the pathogenic Kurkino virus (KURV), were detected in their natural hosts trapped at several study sites in the Czech Republic. KURV was detected mainly in its typical host, the striped field mouse (Apodemus agrarius). Nevertheless, spillover infections were also detected in wood mice (Apodemus sylvaticus) and common voles (Microtus arvalis). Similarly, Tula virus (TULV) was found primarily in common voles, and events of spillover to rodents of other host species, including Apodemus spp., were recorded. In addition, unlike most previous studies, different tissues were sampled and compared to assess their suitability for orthohantavirus screening and possible tissue tropism. Our data suggest possible virus-specific tissue tropism in rodent hosts. TULV was most commonly detected in the lung tissue, whereas KURV was more common in the liver, spleen, and brain. Moreover, Seewis and Asikkala viruses were detected in randomly found common shrews (Sorex araneus). In conclusion, we have demonstrated the presence of human-pathogenic KURV and the potentially pathogenic TULV in their typical hosts as well as their spillover to atypical host species belonging to another family. Furthermore, we suggest the possibility of virus-specific tissue tropism of orthohantaviruses in their natural hosts.