| PUPÍKOVÁ, Monika, Patrik ŠIMKO, Martin LAMOŠ, Martin GAJDOŠ a Irena REKTOROVÁ. Inter-individual differences in baseline dynamic functional connectivity are linked to cognitive aftereffects of tDCS. Scientific Reports. Berlin: Springer Nature, 2022, roč. 12, č. 1, s. 1-12. ISSN 2045-2322. Dostupné z: https://dx.doi.org/10.1038/s41598-022-25016-5. |
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@article{2236213,
author = {Pupíková, Monika and Šimko, Patrik and Lamoš, Martin and Gajdoš, Martin and Rektorová, Irena},
article_location = {Berlin},
article_number = {1},
doi = {http://dx.doi.org/10.1038/s41598-022-25016-5},
keywords = {tDCS; baseline dynamic functional connectivity},
language = {eng},
issn = {2045-2322},
journal = {Scientific Reports},
title = {Inter-individual differences in baseline dynamic functional connectivity are linked to cognitive aftereffects of tDCS},
url = {https://www.nature.com/articles/s41598-022-25016-5},
volume = {12},
year = {2022}
}
TY - JOUR
ID - 2236213
AU - Pupíková, Monika - Šimko, Patrik - Lamoš, Martin - Gajdoš, Martin - Rektorová, Irena
PY - 2022
TI - Inter-individual differences in baseline dynamic functional connectivity are linked to cognitive aftereffects of tDCS
JF - Scientific Reports
VL - 12
IS - 1
SP - 1-12
EP - 1-12
PB - Springer Nature
SN - 20452322
KW - tDCS
KW - baseline dynamic functional connectivity
UR - https://www.nature.com/articles/s41598-022-25016-5
N2 - Transcranial direct current stimulation (tDCS) has the potential to modulate cognitive training in healthy aging; however, results from various studies have been inconsistent. We hypothesized that inter-individual differences in baseline brain state may contribute to the varied results. We aimed to explore whether baseline resting-state dynamic functional connectivity (rs-dFC) and/or conventional resting-state static functional connectivity (rs-sFC) may be related to the magnitude of cognitive aftereffects of tDCS. To achieve this aim, we used data from our double-blind randomized sham-controlled cross-over tDCS trial in 25 healthy seniors in which bifrontal tDCS combined with cognitive training had induced significant behavioral aftereffects. We performed a backward regression analysis including rs-sFC/rs-dFC measures to explain the variability in the magnitude of tDCS-induced improvements in visual object-matching task (VOMT) accuracy. Rs-dFC analysis revealed four rs-dFC states. The occurrence rate of a rs-dFC state 4, characterized by a high correlation between the left fronto-parietal control network and the language network, was significantly associated with tDCS-induced VOMT accuracy changes. The rs-sFC measure was not significantly associated with the cognitive outcome. We show that flexibility of the brain state representing readiness for top-down control of object identification implicated in the studied task is linked to the tDCS-enhanced task accuracy.
ER -
PUPÍKOVÁ, Monika, Patrik ŠIMKO, Martin LAMOŠ, Martin GAJDOŠ a Irena REKTOROVÁ. Inter-individual differences in baseline dynamic functional connectivity are linked to cognitive aftereffects of tDCS. \textit{Scientific Reports}. Berlin: Springer Nature, 2022, roč.~12, č.~1, s.~1-12. ISSN~2045-2322. Dostupné z: https://dx.doi.org/10.1038/s41598-022-25016-5.
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