Pesticide exposure among Czech adults and children from the
CELSPAC-SPECIMEn cohort: Urinary biomarker levels and
associated health risks

J 2022

Pesticide exposure among Czech adults and children from the CELSPAC-SPECIMEn cohort: Urinary biomarker levels and associated health risks

ŠULC, Libor; Tomáš JANOŠ; Daniel FIGUEIREDO; Ilse OTTENBROS; Petr ŠENK et al.

Základní údaje

Originální název

Pesticide exposure among Czech adults and children from the CELSPAC-SPECIMEn cohort: Urinary biomarker levels and associated health risks

Autoři

ŠULC, Libor; Tomáš JANOŠ; Daniel FIGUEIREDO; Ilse OTTENBROS; Petr ŠENK; Ondřej MIKEŠ ; Anke HUSS a Pavel ČUPR

Vydání

Environmental Research, SAN DIEGO, ACADEMIC PRESS INC ELSEVIER SCIENCE, 2022, 0013-9351

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10511 Environmental sciences

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 8.300

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14310/22:00127395

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova anglicky

Pyrethroids; Chlorpyrifos; Tebuconazole; Urine; HBM4EU; Cumulative risk assessment

Štítky

143180, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 10. 6. 2025 15:34, Mgr. Michaela Hylsová, Ph.D.

Anotace

V originále

Current-use pesticides (CUP) are extensively applied in both agricultural and urban settings. Exposure occurs mainly via the dietary pathway; however, other pathways such as inhalation or skin contact are also important. In this study, urinary levels of 12 CUP metabolites were investigated among 110 parent-child pairs during two seasons of 2020. Metabolites of pyrethroids (3-PBA, t/c-DCCA), chlorpyrifos (TCPY), and tebuconazole (TEB-OH) were detected in more than 60% of the samples. Chlorpyrifos metabolite was found at the highest concentration and tebuconazole was detected in almost all samples. CUP urinary metabolite levels were significantly higher in children in comparison to adults, except for tebuconazole, which was similar in both groups. In children, winter samples had significantly higher concentrations of pyrethroid and chlorpyrifos metabolites in comparison to the summer samples, but in adults, only chlorpyrifos metabolite concentrations were higher in the winter. No as-sociation between CUP urinary metabolite levels and proximity/surface of agricultural areas around residences was observed. Based on our findings, we suspect that CUP exposure is mainly driven by diet and that the effect of environmental exposure is less significant. Daily Intakes were estimated with three possible scenarios considering the amount of the metabolite excreted in urine and were compared to Acceptable Daily Intake values. Using a realistic scenario, exposure to chlorpyrifos exhibited the highest health risk, but still within a safe level. The Acceptable Daily Intake was exceeded only in one child in the case of cypermethrin. The cumulative risk assessment of pesticide mixtures having an effect on the nervous system, based on the total margin of exposure calculations, did not indicate any risk. The overall risk associated with pesticide exposure in the observed population was low. However, the risk observed using the worst-case scenario suggests the need for continuous evaluation of human exposure to such compounds, especially in children.

Návaznosti

EF17_043/0009632, projekt VaV

Název: CETOCOEN Excellence

101057014, interní kód MU

Název: Partnership for the Assessment of Risks from Chemicals (Akronym: PARC)

Investor: Evropská unie, Partnership for the Assessment of Risks from Chemicals, Klastr 1 - Zdraví

733032, interní kód MU

Název: European Human Biomonitoring Initiative (Akronym: HBM4EU)

Investor: Evropská unie, European Human Biomonitoring Initiative, Health, demographic change and wellbeing (Societal Challenges)

857340, interní kód MU

Název: External and Internal Human Exposure in Urban EXposome (Akronym: Urban_X)

Investor: Evropská unie, External and Internal Human Exposure in Urban EXposome, Spreading excellence and widening participation

90121, velká výzkumná infrastruktura

Název: RECETOX RI

Přiložené soubory

2238146.pdf

Citovat

ŠULC, Libor; Tomáš JANOŠ; Daniel FIGUEIREDO; Ilse OTTENBROS; Petr ŠENK; Ondřej MIKEŠ; Anke HUSS a Pavel ČUPR. Pesticide exposure among Czech adults and children from the CELSPAC-SPECIMEn cohort: Urinary biomarker levels and associated health risks. Environmental Research. SAN DIEGO: ACADEMIC PRESS INC ELSEVIER SCIENCE, 2022, roč. 214, November 2022, s. 1-12. ISSN 0013-9351. Dostupné z: https://doi.org/10.1016/j.envres.2022.114002.

@article{2238146,
   author = {Šulc, Libor and Janoš, Tomáš and Figueiredo, Daniel and Ottenbros, Ilse and Šenk, Petr and Mikeš, Ondřej and Huss, Anke and Čupr, Pavel},
   article_location = {SAN DIEGO},
   article_number = {November 2022},
   doi = {https://doi.org/10.1016/j.envres.2022.114002},
   keywords = {Pyrethroids; Chlorpyrifos; Tebuconazole; Urine; HBM4EU; Cumulative risk assessment},
   language = {eng},
   issn = {0013-9351},
   journal = {Environmental Research},
   title = {Pesticide exposure among Czech adults and children from the CELSPAC-SPECIMEn cohort: Urinary biomarker levels and associated health risks},
   url = {https://www.sciencedirect.com/science/article/pii/S0013935122013299?via%3Dihub},
   volume = {214},
   year = {2022}
}

TY  - JOUR
ID  - 2238146
AU  - Šulc, Libor - Janoš, Tomáš - Figueiredo, Daniel - Ottenbros, Ilse - Šenk, Petr - Mikeš, Ondřej - Huss, Anke - Čupr, Pavel
PY  - 2022
TI  - Pesticide exposure among Czech adults and children from the CELSPAC-SPECIMEn cohort: Urinary biomarker levels and associated health risks
JF  - Environmental Research
VL  - 214
IS  - November 2022
SP  - 1-12
EP  - 1-12
PB  - ACADEMIC PRESS INC ELSEVIER SCIENCE
SN  - 00139351
KW  - Pyrethroids
KW  - Chlorpyrifos
KW  - Tebuconazole
KW  - Urine
KW  - HBM4EU
KW  - Cumulative risk assessment
UR  - https://www.sciencedirect.com/science/article/pii/S0013935122013299?via%3Dihub
N2  - Current-use pesticides (CUP) are extensively applied in both agricultural and urban settings. Exposure occurs mainly via the dietary pathway; however, other pathways such as inhalation or skin contact are also important. In this study, urinary levels of 12 CUP metabolites were investigated among 110 parent-child pairs during two seasons of 2020. Metabolites of pyrethroids (3-PBA, t/c-DCCA), chlorpyrifos (TCPY), and tebuconazole (TEB-OH) were detected in more than 60% of the samples. Chlorpyrifos metabolite was found at the highest concentration and tebuconazole was detected in almost all samples. CUP urinary metabolite levels were significantly higher in children in comparison to adults, except for tebuconazole, which was similar in both groups. In children, winter samples had significantly higher concentrations of pyrethroid and chlorpyrifos metabolites in comparison to the summer samples, but in adults, only chlorpyrifos metabolite concentrations were higher in the winter. No as-sociation between CUP urinary metabolite levels and proximity/surface of agricultural areas around residences was observed. Based on our findings, we suspect that CUP exposure is mainly driven by diet and that the effect of environmental exposure is less significant. Daily Intakes were estimated with three possible scenarios considering the amount of the metabolite excreted in urine and were compared to Acceptable Daily Intake values. Using a realistic scenario, exposure to chlorpyrifos exhibited the highest health risk, but still within a safe level. The Acceptable Daily Intake was exceeded only in one child in the case of cypermethrin. The cumulative risk assessment of pesticide mixtures having an effect on the nervous system, based on the total margin of exposure calculations, did not indicate any risk. The overall risk associated with pesticide exposure in the observed population was low. However, the risk observed using the worst-case scenario suggests the need for continuous evaluation of human exposure to such compounds, especially in children.
ER  -

ŠULC, Libor; Tomáš JANOŠ; Daniel FIGUEIREDO; Ilse OTTENBROS; Petr ŠENK; Ondřej MIKEŠ; Anke HUSS a Pavel ČUPR. Pesticide exposure among Czech adults and children from the CELSPAC-SPECIMEn cohort: Urinary biomarker levels and associated health risks. \textit{Environmental Research}. SAN DIEGO: ACADEMIC PRESS INC ELSEVIER SCIENCE, 2022, roč.~214, November 2022, s.~1-12. ISSN~0013-9351. Dostupné z: https://doi.org/10.1016/j.envres.2022.114002.

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