Aberrations induced in chromosome 1, 2 and Y of human
lymphocytes by three types of radiation of different LET value
as detected by FISH

D 1999

Aberrations induced in chromosome 1, 2 and Y of human lymphocytes by three types of radiation of different LET value as detected by FISH

LUKÁŠOVÁ, Emilie; Stanislav KOZUBEK; Raisa GOVORUN; Michail REPIN; Leonard RÝZNAR et. al.

Základní údaje

Originální název

Aberrations induced in chromosome 1, 2 and Y of human lymphocytes by three types of radiation of different LET value as detected by FISH

Autoři

LUKÁŠOVÁ, Emilie (203 Česká republika); Stanislav KOZUBEK (203 Česká republika); Raisa GOVORUN; Michail REPIN; Leonard RÝZNAR; Evgenij KRASAVIN; Michal KOZUBEK (203 Česká republika) a Václav KROHA
edited by C.Baumstark-Khan, S.Kozubek, G.Horneck.

Vydání

Dordrecht, Fundamentals for the assesment of risks from environmental radiation, s. 195-202, 1999

Nakladatel

Kluwer Academic Publishers

Další údaje

Jazyk

angličtina

Typ výsledku

Stať ve sborníku

Obor

10610 Biophysics

Stát vydavatele

Nizozemské království

Utajení

není předmětem státního či obchodního tajemství

Kód RIV

RIV/00216224:14330/99:00001494

Organizační jednotka

Fakulta informatiky

ISBN

0-7923-5667-5

Změněno: 8. 7. 2003 10:27, Ing. Libor Holuša, CSc.

Anotace

V originále

Fluorescence in situ hybridisation was used to determine the efficiency of the induction of aberrations in chromosomes 1, 2 and Y of human lymphocytes by gamma-rays, fast neutrons of mean energy of 7 MeV and accelerated nitrogen ions. The frequency and the spectrum of aberration types induced by these three types of radiation were different. Nitrogen ions induced the highest number of aberrations. The most frequent were chromosome fragments followed by centric rings. Neutrons and gamma-rays induced most frequently translocations followed by dicentric chromosomes. Efficiency of neutrons in the induction of aberrations was higher in comparison with gamma-rays. Induction of aberrations by both gamma-rays and fast neutrons in Y chromosome was much less effective in comparison with chromosome 1. The low efficiency of these types of radiation in the induction of aberrations in Y chromosome is probably related to the lower content of DNA in this chromosome and to its higher content of heterochromatin.

Návaznosti

GA202/96/0602, projekt VaV

Název: Modernizace generátoru rychlých neutronů ÚJF pro biofyzikální výzkum

GA202/96/1718, projekt VaV

Název: Stanovení stabilních chromosomálních aberací indukovaných v buňkách lidské krve hustě ionizujícím zářením

Investor: Grantová agentura ČR, Stanovení stabilních chromosomálních aberací indukovaných v buňkách lidské krve hustě ionizujícím zářením

MSM 143300002, záměr

Název: Využití počítačové analýzy obrazu v optické mikroskopii

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Využití počítačové analýzy obrazu v optické mikroskopii

NM15, projekt VaV

Název: Užití interfázní FISH techniky pro vyhledávání lidí se zvýšeným rizikem vzniku zhoubných hemoblastóz

Investor: Ministerstvo zdravotnictví ČR, Užití interfázní FISH techniky pro vyhledávání lidí se zvýšeným rizikem vzniku zhoubných hemoblastóz

Citovat

LUKÁŠOVÁ, Emilie; Stanislav KOZUBEK; Raisa GOVORUN; Michail REPIN; Leonard RÝZNAR; Evgenij KRASAVIN; Michal KOZUBEK a Václav KROHA. Aberrations induced in chromosome 1, 2 and Y of human lymphocytes by three types of radiation of different LET value as detected by FISH. edited by C.Baumstark-Khan, S.Kozubek, G.Horneck. In Fundamentals for the assesment of risks from environmental radiation. Dordrecht: Kluwer Academic Publishers, 1999, s. 195-202. ISBN 0-7923-5667-5.

@inproceedings{224271,
   author = {Lukášová, Emilie and Kozubek, Stanislav and Govorun, Raisa and Repin, Michail and Rýznar, Leonard and Krasavin, Evgenij and Kozubek, Michal and Kroha, Václav},
   address = {Dordrecht},
   booktitle = {Fundamentals for the assesment of risks from environmental radiation},
   language = {eng},
   location = {Dordrecht},
   isbn = {0-7923-5667-5},
   pages = {195-202},
   publisher = {Kluwer Academic Publishers},
   title = {Aberrations induced in chromosome 1, 2 and Y of human lymphocytes by three types of radiation of different LET value as detected by FISH},
   year = {1999}
}

TY  - CONF
ID  - 224271
AU  - Lukášová, Emilie - Kozubek, Stanislav - Govorun, Raisa - Repin, Michail - Rýznar, Leonard - Krasavin, Evgenij - Kozubek, Michal - Kroha, Václav
PY  - 1999
TI  - Aberrations induced in chromosome 1, 2 and Y of human lymphocytes by three types of radiation of different LET value as detected by FISH
PB  - Kluwer Academic Publishers
CY  - Dordrecht
SN  - 0792356675
N2  - Fluorescence in situ hybridisation was used to determine the efficiency of the induction of aberrations in chromosomes 1, 2 and Y of human lymphocytes by gamma-rays, fast neutrons of mean energy of 7 MeV and accelerated nitrogen ions. The frequency and the spectrum of aberration types induced by these three types of radiation were different. Nitrogen ions induced the highest number of aberrations. The most frequent were chromosome fragments followed by centric rings. Neutrons and gamma-rays induced most frequently translocations followed by dicentric chromosomes. Efficiency of neutrons in the induction of aberrations was higher in comparison with gamma-rays. Induction of aberrations by both gamma-rays and fast neutrons in Y chromosome was much less effective in comparison with chromosome 1. The low efficiency of these types of radiation in the induction of aberrations in Y chromosome is probably related to the lower content of DNA in this chromosome and to its higher content of heterochromatin.
ER  -

LUKÁŠOVÁ, Emilie; Stanislav KOZUBEK; Raisa GOVORUN; Michail REPIN; Leonard RÝZNAR; Evgenij KRASAVIN; Michal KOZUBEK a Václav KROHA. Aberrations induced in chromosome 1, 2 and Y of human lymphocytes by three types of radiation of different LET value as detected by FISH. edited by C.Baumstark-Khan, S.Kozubek, G.Horneck. In \textit{Fundamentals for the assesment of risks from environmental radiation}. Dordrecht: Kluwer Academic Publishers, 1999, s.~195-202. ISBN~0-7923-5667-5.

Přehled o publikaci