Composition and toxicity of venom produced by araneophagous
white-tailed spiders (Lamponidae: Lampona sp.﻿)

J 2022

Composition and toxicity of venom produced by araneophagous white-tailed spiders (Lamponidae: Lampona sp.)

MICHÁLEK, Ondřej; Andrew A. WALKER; Ondrej ŠEDO; Zbyněk ZDRÁHAL; Glenn F. KING et al.

Základní údaje

Originální název

Composition and toxicity of venom produced by araneophagous white-tailed spiders (Lamponidae: Lampona sp.)

Autoři

MICHÁLEK, Ondřej; Andrew A. WALKER; Ondrej ŠEDO; Zbyněk ZDRÁHAL; Glenn F. KING a Stanislav PEKÁR

Vydání

SCIENTIFIC REPORTS, ENGLAND, NATURE PORTFOLIO, 2022, 2045-2322

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10600 1.6 Biological sciences

Stát vydavatele

Německo

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.600

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14310/22:00127725

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova anglicky

white-tailed spiders; Prey-specialised spiders; spiders; Lampona

Štítky

14314020, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 5. 3. 2026 09:30, Mgr. Marie Novosadová Šípková, DiS.

Anotace

V originále

Prey-specialised spiders are adapted to capture specific prey items, including dangerous prey. The venoms of specialists are often prey-specific and less complex than those of generalists, but their venom composition has not been studied in detail. Here, we investigated the venom of the prey-specialised white-tailed spiders (Lamponidae: Lampona), which utilise specialised morphological and behavioural adaptations to capture spider prey. We analysed the venom composition using proteo-transcriptomics and taxon-specific toxicity using venom bioassays. Our analysis identified 208 putative toxin sequences, comprising 103 peptides < 10 kDa and 105 proteins > 10 kDa. Most peptides belonged to one of two families characterised by scaffolds containing eight or ten cysteine residues. Toxin-like proteins showed similarity to galectins, leucine-rich repeat proteins, trypsins and neprilysins. The venom of Lampona was shown to be more potent against the preferred spider prey than against alternative cricket prey. In contrast, the venom of a related generalist was similarly potent against both prey types. These data provide insights into the molecular adaptations of venoms produced by prey-specialised spiders.

Návaznosti

90127, velká výzkumná infrastruktura

Název: CIISB II

Citovat

MICHÁLEK, Ondřej; Andrew A. WALKER; Ondrej ŠEDO; Zbyněk ZDRÁHAL; Glenn F. KING a Stanislav PEKÁR. Composition and toxicity of venom produced by araneophagous white-tailed spiders (Lamponidae: Lampona sp.). SCIENTIFIC REPORTS. ENGLAND: NATURE PORTFOLIO, 2022, roč. 12, č. 1, s. "21597", 13 s. ISSN 2045-2322. Dostupné z: https://doi.org/10.1038/s41598-022-24694-5.

@article{2243765,
   author = {Michálek, Ondřej and Walker, Andrew A. and Šedo, Ondrej and Zdráhal, Zbyněk and King, Glenn F. and Pekár, Stanislav},
   article_location = {ENGLAND},
   article_number = {1},
   doi = {https://doi.org/10.1038/s41598-022-24694-5},
   keywords = {white-tailed spiders; Prey-specialised spiders; spiders; Lampona},
   language = {eng},
   issn = {2045-2322},
   journal = {SCIENTIFIC REPORTS},
   title = {Composition and toxicity of venom produced by araneophagous white-tailed spiders (Lamponidae: Lampona sp.)},
   url = {https://doi.org/10.1038/s41598-022-24694-5},
   volume = {12},
   year = {2022}
}

TY  - JOUR
ID  - 2243765
AU  - Michálek, Ondřej - Walker, Andrew A. - Šedo, Ondrej - Zdráhal, Zbyněk - King, Glenn F. - Pekár, Stanislav
PY  - 2022
TI  - Composition and toxicity of venom produced by araneophagous white-tailed spiders (Lamponidae: Lampona sp.)
JF  - SCIENTIFIC REPORTS
VL  - 12
IS  - 1
SP  - "21597"
EP  - "21597"
PB  - NATURE PORTFOLIO
SN  - 20452322
KW  - white-tailed spiders
KW  - Prey-specialised spiders
KW  - spiders
KW  - Lampona
UR  - https://doi.org/10.1038/s41598-022-24694-5
N2  - Prey-specialised spiders are adapted to capture specific prey items, including dangerous prey. The venoms of specialists are often prey-specific and less complex than those of generalists, but their venom composition has not been studied in detail. Here, we investigated the venom of the prey-specialised white-tailed spiders (Lamponidae: Lampona), which utilise specialised morphological and behavioural adaptations to capture spider prey. We analysed the venom composition using proteo-transcriptomics and taxon-specific toxicity using venom bioassays. Our analysis identified 208 putative toxin sequences, comprising 103 peptides < 10 kDa and 105 proteins > 10 kDa. Most peptides belonged to one of two families characterised by scaffolds containing eight or ten cysteine residues. Toxin-like proteins showed similarity to galectins, leucine-rich repeat proteins, trypsins and neprilysins. The venom of Lampona was shown to be more potent against the preferred spider prey than against alternative cricket prey. In contrast, the venom of a related generalist was similarly potent against both prey types. These data provide insights into the molecular adaptations of venoms produced by prey-specialised spiders.
ER  -

MICHÁLEK, Ondřej; Andrew A. WALKER; Ondrej ŠEDO; Zbyněk ZDRÁHAL; Glenn F. KING a Stanislav PEKÁR. Composition and toxicity of venom produced by araneophagous white-tailed spiders (Lamponidae: Lampona sp.). \textit{SCIENTIFIC REPORTS}. ENGLAND: NATURE PORTFOLIO, 2022, roč.~12, č.~1, s.~''21597'', 13 s. ISSN~2045-2322. Dostupné z: https://doi.org/10.1038/s41598-022-24694-5.

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