Long-term home parenteral nutrition and profile of amino acids
in serum and their loss in urine

J 2023

Long-term home parenteral nutrition and profile of amino acids in serum and their loss in urine

DASTYCH, Milan; Michal ŠENKYŘÍK; Alena MIKUŠKOVÁ a Milan DASTYCH

Základní údaje

Originální název

Long-term home parenteral nutrition and profile of amino acids in serum and their loss in urine

Autoři

DASTYCH, Milan; Michal ŠENKYŘÍK; Alena MIKUŠKOVÁ a Milan DASTYCH

Vydání

British Journal of Nutrition, CAMBRIDGE, Cambridge University Press, 2023, 0007-1145

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30308 Nutrition, Dietetics

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.000

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/23:00130207

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

Home parenteral nutrition; Essential amino acids; Ion exchange chromatography; Quality of life

Štítky

14110213, 14110616, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 26. 1. 2024 10:41, Mgr. Tereza Miškechová

Anotace

V originále

Amino acids are an essential part of parenteral nutrition. This study aimed to determine the serum profile of amino acids and their loss in urine in patients with long-term home parenteral nutrition (HPN) during 12 h of infusion in comparison with similar parameters in the remaining 12 has well as in healthy participants. We enrolled forty-five patients with long-term HPN for 6-75 (median, 33) months. The indication for HPN was short bowel syndrome secondary to radical resection of the small intestine following complications of Crohn's disease. HPN was administered via two-chamber all-in-one bags prepared in a hospital pharmacy overnight for 12 h each day. The average dose of amino acids, carbohydrates and fats administered was 1.5, 3.4 and 0.68 g/kg per d, respectively, at an infusion rate of 0.11, 0.28 and 0.06 g/kg per h, respectively. The levels of essential amino acids in the serum of the patients were not significantly different from those in healthy individuals; however, of the non-essential amino acids, cystine and glutamine levels were lower and glycine and ornithine levels were higher in the patients (P < 0.05). Excretion of amino acids in the urine during 12 h of infusion at an infusion rate of 0.11 g/kg per h was 301 mg, while it was 104 mg during the remaining 12 h (P < 0.0001). Our patients on long-term HPN had a normal serum profile of essential amino acids. The total urinary excretion of amino acids during 12 h of infusion accounted for only 0.34 % (0-23-0.46) of the administered dose.

Citovat

DASTYCH, Milan; Michal ŠENKYŘÍK; Alena MIKUŠKOVÁ a Milan DASTYCH. Long-term home parenteral nutrition and profile of amino acids in serum and their loss in urine. British Journal of Nutrition. CAMBRIDGE: Cambridge University Press, 2023, roč. 129, č. 9, s. 1537-1542. ISSN 0007-1145. Dostupné z: https://doi.org/10.1017/S0007114522002008.

@article{2248076,
   author = {Dastych, Milan and Šenkyřík, Michal and Mikušková, Alena and Dastych, Milan},
   article_location = {CAMBRIDGE},
   article_number = {9},
   doi = {https://doi.org/10.1017/S0007114522002008},
   keywords = {Home parenteral nutrition; Essential amino acids; Ion exchange chromatography; Quality of life},
   language = {eng},
   issn = {0007-1145},
   journal = {British Journal of Nutrition},
   title = {Long-term home parenteral nutrition and profile of amino acids in serum and their loss in urine},
   url = {https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/longterm-home-parenteral-nutrition-and-profile-of-amino-acids-in-serum-and-their-loss-in-urine/F9AE53803D7AA9C4D5C24F1314EE51BF},
   volume = {129},
   year = {2023}
}

TY  - JOUR
ID  - 2248076
AU  - Dastych, Milan - Šenkyřík, Michal - Mikušková, Alena - Dastych, Milan
PY  - 2023
TI  - Long-term home parenteral nutrition and profile of amino acids in serum and their loss in urine
JF  - British Journal of Nutrition
VL  - 129
IS  - 9
SP  - 1537-1542
EP  - 1537-1542
PB  - Cambridge University Press
SN  - 00071145
KW  - Home parenteral nutrition
KW  - Essential amino acids
KW  - Ion exchange chromatography
KW  - Quality of life
UR  - https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/longterm-home-parenteral-nutrition-and-profile-of-amino-acids-in-serum-and-their-loss-in-urine/F9AE53803D7AA9C4D5C24F1314EE51BF
N2  - Amino acids are an essential part of parenteral nutrition. This study aimed to determine the serum profile of amino acids and their loss in urine in patients with long-term home parenteral nutrition (HPN) during 12 h of infusion in comparison with similar parameters in the remaining 12 has well as in healthy participants. We enrolled forty-five patients with long-term HPN for 6-75 (median, 33) months. The indication for HPN was short bowel syndrome secondary to radical resection of the small intestine following complications of Crohn's disease. HPN was administered via two-chamber all-in-one bags prepared in a hospital pharmacy overnight for 12 h each day. The average dose of amino acids, carbohydrates and fats administered was 1.5, 3.4 and 0.68 g/kg per d, respectively, at an infusion rate of 0.11, 0.28 and 0.06 g/kg per h, respectively. The levels of essential amino acids in the serum of the patients were not significantly different from those in healthy individuals; however, of the non-essential amino acids, cystine and glutamine levels were lower and glycine and ornithine levels were higher in the patients (P < 0.05). Excretion of amino acids in the urine during 12 h of infusion at an infusion rate of 0.11 g/kg per h was 301 mg, while it was 104 mg during the remaining 12 h (P < 0.0001). Our patients on long-term HPN had a normal serum profile of essential amino acids. The total urinary excretion of amino acids during 12 h of infusion accounted for only 0.34 % (0-23-0.46) of the administered dose.
ER  -

DASTYCH, Milan; Michal ŠENKYŘÍK; Alena MIKUŠKOVÁ a Milan DASTYCH. Long-term home parenteral nutrition and profile of amino acids in serum and their loss in urine. \textit{British Journal of Nutrition}. CAMBRIDGE: Cambridge University Press, 2023, roč.~129, č.~9, s.~1537-1542. ISSN~0007-1145. Dostupné z: https://doi.org/10.1017/S0007114522002008.

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