HICKS, Tara, Shalini TRIVEDI, Mikayla EPPERT, Richard BOWMAN, Hui TIAN, Amna DAFALLA, Caroline CRAHAN, Sarit SMOLIKOVE a Nicola SILVA. Continuous double-strand break induction and their differential processing sustain chiasma formation during Caenorhabditis elegans meiosis. Cell Reports. CAMBRIDGE: Cell Press, 2022, roč. 40, č. 13, s. 1-20. ISSN 2211-1247. Dostupné z: https://dx.doi.org/10.1016/j.celrep.2022.111403. |
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@article{2248097, author = {Hicks, Tara and Trivedi, Shalini and Eppert, Mikayla and Bowman, Richard and Tian, Hui and Dafalla, Amna and Crahan, Caroline and Smolikove, Sarit and Silva, Nicola}, article_location = {CAMBRIDGE}, article_number = {13}, doi = {http://dx.doi.org/10.1016/j.celrep.2022.111403}, keywords = {Caenorhabditis elegans meiosis; double-strand break induction; sustain chiasma formation}, language = {eng}, issn = {2211-1247}, journal = {Cell Reports}, title = {Continuous double-strand break induction and their differential processing sustain chiasma formation during Caenorhabditis elegans meiosis}, url = {https://www.sciencedirect.com/science/article/pii/S2211124722012402?via%3Dihub}, volume = {40}, year = {2022} }
TY - JOUR ID - 2248097 AU - Hicks, Tara - Trivedi, Shalini - Eppert, Mikayla - Bowman, Richard - Tian, Hui - Dafalla, Amna - Crahan, Caroline - Smolikove, Sarit - Silva, Nicola PY - 2022 TI - Continuous double-strand break induction and their differential processing sustain chiasma formation during Caenorhabditis elegans meiosis JF - Cell Reports VL - 40 IS - 13 SP - 1-20 EP - 1-20 PB - Cell Press SN - 22111247 KW - Caenorhabditis elegans meiosis KW - double-strand break induction KW - sustain chiasma formation UR - https://www.sciencedirect.com/science/article/pii/S2211124722012402?via%3Dihub N2 - Faithful chromosome segregation into gametes depends on Spo11-induced DNA double-strand breaks (DSBs). These yield single-stranded 30 tails upon resection to promote crossovers (COs). While early Mre11-dependent end resection is the predominant pathway in most organisms, Exo1 or Dna2/BLM can also contribute to the efficient processing of meiotic DSBs. Although its enzymatic activity has been thor-oughly dissected, the temporal dynamics underlying Spo11 activity have remained mostly elusive. We show that, in Caenorhabditis elegans, SPO-11-mediated DSB induction takes place throughout early meiotic prophase I until mid-late pachynema. We find that late DSBs are essential for CO formation and are prefer-entially processed by EXO-1 and DNA-2 in a redundant fashion. Further, EXO-1-DNA-2-mediated resection ensures completion of conservative DSB repair and discourages activation of KU-dependent end joining. Taken together, our data unveil important temporal aspects of DSB induction and identify previously un-known functional implications for EXO-1-DNA-2-mediated resection activity in C. elegans. ER -
HICKS, Tara, Shalini TRIVEDI, Mikayla EPPERT, Richard BOWMAN, Hui TIAN, Amna DAFALLA, Caroline CRAHAN, Sarit SMOLIKOVE a Nicola SILVA. Continuous double-strand break induction and their differential processing sustain chiasma formation during Caenorhabditis elegans meiosis. \textit{Cell Reports}. CAMBRIDGE: Cell Press, 2022, roč.~40, č.~13, s.~1-20. ISSN~2211-1247. Dostupné z: https://dx.doi.org/10.1016/j.celrep.2022.111403.
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