J 2022

Assessment of late cardiotoxic effects in patients treated for cancer in childhood

KINCL, Vladimír, Roman PANOVSKÝ, Tomáš KEPÁK, Viera BAJČIOVÁ, Veronika BEDNÁROVÁ et. al.

Základní údaje

Originální název

Assessment of late cardiotoxic effects in patients treated for cancer in childhood

Autoři

KINCL, Vladimír (203 Česká republika, garant, domácí), Roman PANOVSKÝ (203 Česká republika, domácí), Tomáš KEPÁK (203 Česká republika, domácí), Viera BAJČIOVÁ (703 Slovensko, domácí), Veronika BEDNÁROVÁ (703 Slovensko, domácí), Lukáš OPATŘIL (203 Česká republika, domácí) a Jan MÁCHAL (203 Česká republika, domácí)

Vydání

Cancer Medicine, HOBOKEN, John Wiley & Sons Ltd. 2022, 2045-7634

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30204 Oncology

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

Impakt faktor

Impact factor: 4.000

Kód RIV

RIV/00216224:14110/22:00128258

Organizační jednotka

Lékařská fakulta

DOI

UT WoS

000761794900001

Klíčová slova anglicky

late cardiotoxic effects; cancer in childhood

Štítky

Příznaky

Mezinárodní význam, Recenzováno
Změněno: 25. 1. 2023 09:24, Mgr. Tereza Miškechová

Anotace

V originále

Background: The most frequent chemotherapeutic regimens used in children's cancer contain anthracyclines, which may have potentially cardiotoxic effects even at a later point in time. Echocardiography including tissue Doppler imaging is well-proved noninvasive method to assess cardiac function. Objectives: To assess the late cardiotoxic effects in young adults treated for various cancer types in childhood. Methods: Ninety-eight young adults who were treated for childhood cancer (CCS), median time 12.1 years after finishing the therapy, were comprised into study. All subjects underwent echocardiographic examination including tissue Doppler imaging. The echocardiographic parameters were compared to 57 healthy age-matched subjects. The CCS group also underwent 24-h ECG Holter monitoring to reveal any arrhythmias. Results: The subjects in CCS group had lower E' velocities from lateral (15.6 vs. 17.6 cm/s) and septal part (12.2 vs. 14.4 cm/s) of mitral annulus (p for both <0.001) and also lower S' velocity from the tricuspid annulus (12.4. vs. 13.3 cm/s, p = 0.013) and tricuspid annulus peak systolic excursion (TAPSE; 22.2 vs. 23.9 mm, p = 0.017). There were no significant differences in left ventricular systolic velocities or ejection fraction. The occurrence of arrhythmias did not differ among subgroups of CCS with or without anthracycline therapy. Conclusion: Childhood cancer survivors had subclinical cardiac impairment in comparison with healthy controls, particularly in left ventricular diastolic function.

Návaznosti

MUNI/A/1685/2020, interní kód MU
Název: Nové trendy v diagnostice a terapii kardiomyopatií
Investor: Masarykova univerzita, Nové trendy v diagnostice a terapii kardiomyopatií