Fractional Flow Reserve Versus Instantaneous Wave-Free Ratio in
Assessment of Lesion Hemodynamic Significance and Explanation
of their Discrepancies. International, Multicenter and
Prospective Trial: The FiGARO Study

J 2022

Fractional Flow Reserve Versus Instantaneous Wave-Free Ratio in Assessment of Lesion Hemodynamic Significance and Explanation of their Discrepancies. International, Multicenter and Prospective Trial: The FiGARO Study

KOVARNIK, Tomas; Matsuo HITOSHI; Ales KRAL; Stepan JERABEK; David ZEMANEK et al.

Základní údaje

Originální název

Fractional Flow Reserve Versus Instantaneous Wave-Free Ratio in Assessment of Lesion Hemodynamic Significance and Explanation of their Discrepancies. International, Multicenter and Prospective Trial: The FiGARO Study

Autoři

Vydání

Journal of the American Heart Association, Hoboken, Wiley-Blackwell, 2022, 2047-9980

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30201 Cardiac and Cardiovascular systems

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 5.400

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/22:00129589

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

coronary flow reserve; fractional flow reserve; instantaneous wave-free ratio

Štítky

14110211, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 27. 1. 2023 10:45, Mgr. Tereza Miškechová

Anotace

V originále

Background:The FiGARO (FFR versus iFR in Assessment of Hemodynamic Lesion Significance, and an Explanation of Their Discrepancies) trial is a prospective registry searching for predictors of fractional flow reserve/instantaneous wave-free ratio (FFR/iFR) discrepancy. Methods and Results:FFR/iFR were analyzed using a Verrata wire, and coronary flow reserve was analyzed using a Combomap machine (both Philips-Volcano). The risk polymorphisms for endothelial nitric oxide synthase and for heme oxygenase-1 were analyzed. In total, 1884 FFR/iFR measurements from 1564 patients were included. The FFR/iFR discrepancy occurred in 393 measurements (20.9%): FFRp (positive)/iFRn (negative) type (264 lesions, 14.0%) and FFRn/iFRp (129 lesions, 6.8%) type. Coronary flow reserve was measured in 343 lesions, correlating better with iFR (R=0.56, P<0.0001) than FFR (R=0.36, P<0.0001). The coronary flow reserve value in FFRp/iFRn lesions (2.24 +/- 0.7) was significantly higher compared with both FFRp/iFRp (1.39 +/- 0.36), and FFRn/iFRn lesions (1.8 +/- 0.64, P<0.0001). Multivariable logistic regression analysis confirmed (1) sex, age, and lesion location in the right coronary artery as predictors for FFRp/iFRn discrepancy; and (2) hemoglobin level, smoking, and renal insufficiency as predictors for FFRn/iFRp discrepancy. The FFRn/iFRp type of discrepancy was significantly more frequent in patients with both risk types of polymorphisms (endothelial nitric oxide synthase(r)+heme oxygenase-1(r)): 8 patients (24.2%) compared with FFRp/iFRn type of discrepancy: 2 patients (5.9%), P=0.03. Conclusions:Predictors for FFRp/iFRn discrepancy were sex, age, and location in the right coronary artery. Predictors for FFRn/iFRp were hemoglobin level, smoking, and renal insufficiency. The risk type of polymorphism in endothelial nitric oxide synthase and heme oxygenase-1 genes was more frequently found in patients with FFRn/iFRp type of discrepancy.

Návaznosti

TN01000013, projekt VaV

Název: Personalizovaná medicína - diagnostika a terapie

Investor: Technologická agentura ČR, Personalizovaná medicína - diagnostika a terapie

Citovat

KOVARNIK, Tomas; Matsuo HITOSHI; Ales KRAL; Stepan JERABEK; David ZEMANEK; Yoshiaki KAWASE; Hiroyuki OMORI; Toru TANIGAKI; Jan PUDIL; Alexandra VODZINSKA; Marian BRANNY; Roman ŠTÍPAL; Petr KALA; Jan MROZEK; Martin PORZER; Tomas GREZL; Kamil NOVOBILSKY; Oscar MENDIZ; Karel KOPRIVA; Martin MATES; Martin CHVAL; Zhi CHEN; Pavel MARTASEK a Ales LINHART. Fractional Flow Reserve Versus Instantaneous Wave-Free Ratio in Assessment of Lesion Hemodynamic Significance and Explanation of their Discrepancies. International, Multicenter and Prospective Trial: The FiGARO Study. Journal of the American Heart Association. Hoboken: Wiley-Blackwell, 2022, roč. 11, č. 9, s. 1-17. ISSN 2047-9980. Dostupné z: https://doi.org/10.1161/JAHA.121.021490.

@article{2250029,
   author = {Kovarnik, Tomas and Hitoshi, Matsuo and Kral, Ales and Jerabek, Stepan and Zemanek, David and Kawase, Yoshiaki and Omori, Hiroyuki and Tanigaki, Toru and Pudil, Jan and Vodzinska, Alexandra and Branny, Marian and Štípal, Roman and Kala, Petr and Mrozek, Jan and Porzer, Martin and Grezl, Tomas and Novobilsky, Kamil and Mendiz, Oscar and Kopriva, Karel and Mates, Martin and Chval, Martin and Chen, Zhi and Martasek, Pavel and Linhart, Ales},
   article_location = {Hoboken},
   article_number = {9},
   doi = {https://doi.org/10.1161/JAHA.121.021490},
   keywords = {coronary flow reserve; fractional flow reserve; instantaneous wave-free ratio},
   language = {eng},
   issn = {2047-9980},
   journal = {Journal of the American Heart Association},
   title = {Fractional Flow Reserve Versus Instantaneous Wave-Free Ratio in Assessment of Lesion Hemodynamic Significance and Explanation of their Discrepancies. International, Multicenter and Prospective Trial: The FiGARO Study},
   url = {https://www.ahajournals.org/doi/10.1161/JAHA.121.021490},
   volume = {11},
   year = {2022}
}

TY  - JOUR
ID  - 2250029
AU  - Kovarnik, Tomas - Hitoshi, Matsuo - Kral, Ales - Jerabek, Stepan - Zemanek, David - Kawase, Yoshiaki - Omori, Hiroyuki - Tanigaki, Toru - Pudil, Jan - Vodzinska, Alexandra - Branny, Marian - Štípal, Roman - Kala, Petr - Mrozek, Jan - Porzer, Martin - Grezl, Tomas - Novobilsky, Kamil - Mendiz, Oscar - Kopriva, Karel - Mates, Martin - Chval, Martin - Chen, Zhi - Martasek, Pavel - Linhart, Ales
PY  - 2022
TI  - Fractional Flow Reserve Versus Instantaneous Wave-Free Ratio in Assessment of Lesion Hemodynamic Significance and Explanation of their Discrepancies. International, Multicenter and Prospective Trial: The FiGARO Study
JF  - Journal of the American Heart Association
VL  - 11
IS  - 9
SP  - 1-17
EP  - 1-17
PB  - Wiley-Blackwell
SN  - 20479980
KW  - coronary flow reserve
KW  - fractional flow reserve
KW  - instantaneous wave-free ratio
UR  - https://www.ahajournals.org/doi/10.1161/JAHA.121.021490
N2  - Background:The FiGARO (FFR versus iFR in Assessment of Hemodynamic Lesion Significance, and an Explanation of Their Discrepancies) trial is a prospective registry searching for predictors of fractional flow reserve/instantaneous wave-free ratio (FFR/iFR) discrepancy. Methods and Results:FFR/iFR were analyzed using a Verrata wire, and coronary flow reserve was analyzed using a Combomap machine (both Philips-Volcano). The risk polymorphisms for endothelial nitric oxide synthase and for heme oxygenase-1 were analyzed. In total, 1884 FFR/iFR measurements from 1564 patients were included. The FFR/iFR discrepancy occurred in 393 measurements (20.9%): FFRp (positive)/iFRn (negative) type (264 lesions, 14.0%) and FFRn/iFRp (129 lesions, 6.8%) type. Coronary flow reserve was measured in 343 lesions, correlating better with iFR (R=0.56, P<0.0001) than FFR (R=0.36, P<0.0001). The coronary flow reserve value in FFRp/iFRn lesions (2.24 +/- 0.7) was significantly higher compared with both FFRp/iFRp (1.39 +/- 0.36), and FFRn/iFRn lesions (1.8 +/- 0.64, P<0.0001). Multivariable logistic regression analysis confirmed (1) sex, age, and lesion location in the right coronary artery as predictors for FFRp/iFRn discrepancy; and (2) hemoglobin level, smoking, and renal insufficiency as predictors for FFRn/iFRp discrepancy. The FFRn/iFRp type of discrepancy was significantly more frequent in patients with both risk types of polymorphisms (endothelial nitric oxide synthase(r)+heme oxygenase-1(r)): 8 patients (24.2%) compared with FFRp/iFRn type of discrepancy: 2 patients (5.9%), P=0.03. Conclusions:Predictors for FFRp/iFRn discrepancy were sex, age, and location in the right coronary artery. Predictors for FFRn/iFRp were hemoglobin level, smoking, and renal insufficiency. The risk type of polymorphism in endothelial nitric oxide synthase and heme oxygenase-1 genes was more frequently found in patients with FFRn/iFRp type of discrepancy.
ER  -

KOVARNIK, Tomas; Matsuo HITOSHI; Ales KRAL; Stepan JERABEK; David ZEMANEK; Yoshiaki KAWASE; Hiroyuki OMORI; Toru TANIGAKI; Jan PUDIL; Alexandra VODZINSKA; Marian BRANNY; Roman ŠTÍPAL; Petr KALA; Jan MROZEK; Martin PORZER; Tomas GREZL; Kamil NOVOBILSKY; Oscar MENDIZ; Karel KOPRIVA; Martin MATES; Martin CHVAL; Zhi CHEN; Pavel MARTASEK a Ales LINHART. Fractional Flow Reserve Versus Instantaneous Wave-Free Ratio in Assessment of Lesion Hemodynamic Significance and Explanation of their Discrepancies. International, Multicenter and Prospective Trial: The FiGARO Study. \textit{Journal of the American Heart Association}. Hoboken: Wiley-Blackwell, 2022, roč.~11, č.~9, s.~1-17. ISSN~2047-9980. Dostupné z: https://doi.org/10.1161/JAHA.121.021490.

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