Quantitative MR Markers in Non-Myelopathic Spinal Cord
Compression: A Narrative Review

J 2022

Quantitative MR Markers in Non-Myelopathic Spinal Cord Compression: A Narrative Review

VALOSEK, Jan, Petr BEDNARIK, Miloš KEŘKOVSKÝ, Petr HLUSTIK, Josef BEDNAŘÍK et. al.

Základní údaje

Originální název

Quantitative MR Markers in Non-Myelopathic Spinal Cord Compression: A Narrative Review

Autoři

VALOSEK, Jan (203 Česká republika), Petr BEDNARIK (203 Česká republika), Miloš KEŘKOVSKÝ (203 Česká republika, domácí), Petr HLUSTIK (203 Česká republika), Josef BEDNAŘÍK (203 Česká republika, domácí) a Alena SVATKOVA (203 Česká republika)

Vydání

Journal of Clinical Medicine, BASEL, MDPI, 2022, 2077-0383

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30210 Clinical neurology

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.900

Kód RIV

RIV/00216224:14110/22:00128326

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.3390/jcm11092301

UT WoS

000794815500001

Klíčová slova anglicky

non-myelopathic cervical spinal cord compression; degenerative cervical myelopathy; diffusion magnetic resonance imaging; quantitative magnetic resonance imaging

Štítky

14110216, 14110221, CF MAFIL, podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 10. 10. 2024 09:47, Ing. Jana Kuchtová

Anotace

V originále

Degenerative spinal cord compression is a frequent pathological condition with increasing prevalence throughout aging. Initial non-myelopathic cervical spinal cord compression (NMDC) might progress over time into potentially irreversible degenerative cervical myelopathy (DCM). While quantitative MRI (qMRI) techniques demonstrated the ability to depict intrinsic tissue properties, longitudinal in-vivo biomarkers to identify NMDC patients who will eventually develop DCM are still missing. Thus, we aim to review the ability of qMRI techniques (such as diffusion MRI, diffusion tensor imaging (DTI), magnetization transfer (MT) imaging, and magnetic resonance spectroscopy (H-1-MRS)) to serve as prognostic markers in NMDC. While DTI in NMDC patients consistently detected lower fractional anisotropy and higher mean diffusivity at compressed levels, caused by demyelination and axonal injury, MT and H-1-MRS, along with advanced and tract-specific diffusion MRI, recently revealed microstructural alterations, also rostrally pointing to Wallerian degeneration. Recent studies also disclosed a significant relationship between microstructural damage and functional deficits, as assessed by qMRI and electrophysiology, respectively. Thus, tract-specific qMRI, in combination with electrophysiology, critically extends our understanding of the underlying pathophysiology of degenerative spinal cord compression and may provide predictive markers of DCM development for accurate patient management. However, the prognostic value must be validated in longitudinal studies.

Návaznosti

NU22-04-00024, projekt VaV

Název: Kvantitativní zobrazovací MR parametry jako prediktory průběhu nemyelopatické degenerativní komprese krční míchy: longitudinální studie

Investor: Ministerstvo zdravotnictví ČR, Kvantitativní zobrazovací MR parametry jako prediktory průběhu nemyelopatické degenerativní komprese krční míchy: longitudinální studie, Podprogram 1 - standardní

NV18-04-00159, projekt VaV

Název: Využití pokročilých magneticko-rezonančních technik k odhalení patofyziologie a zlepšení diagnostiky a praktického managementu degenerativní komprese krční míchy

Investor: Ministerstvo zdravotnictví ČR, Využití pokročilých magneticko-rezonančních technik k objasnění patofyziologie a zlepšení diagnostiky a praktického managementu degenerativní komprese krční míchy

90129, velká výzkumná infrastruktura

Název: Czech-BioImaging II

Citovat

VALOSEK, Jan, Petr BEDNARIK, Miloš KEŘKOVSKÝ, Petr HLUSTIK, Josef BEDNAŘÍK a Alena SVATKOVA. Quantitative MR Markers in Non-Myelopathic Spinal Cord Compression: A Narrative Review. Journal of Clinical Medicine. BASEL: MDPI, 2022, roč. 11, č. 9, s. 1-21. ISSN 2077-0383. Dostupné z: https://dx.doi.org/10.3390/jcm11092301.

@article{2250057,
   author = {Valosek, Jan and Bednarik, Petr and Keřkovský, Miloš and Hlustik, Petr and Bednařík, Josef and Svatkova, Alena},
   article_location = {BASEL},
   article_number = {9},
   doi = {http://dx.doi.org/10.3390/jcm11092301},
   keywords = {non-myelopathic cervical spinal cord compression; degenerative cervical myelopathy; diffusion magnetic resonance imaging; quantitative magnetic resonance imaging},
   language = {eng},
   issn = {2077-0383},
   journal = {Journal of Clinical Medicine},
   title = {Quantitative MR Markers in Non-Myelopathic Spinal Cord Compression: A Narrative Review},
   url = {https://www.mdpi.com/2077-0383/11/9/2301},
   volume = {11},
   year = {2022}
}

TY  - JOUR
ID  - 2250057
AU  - Valosek, Jan - Bednarik, Petr - Keřkovský, Miloš - Hlustik, Petr - Bednařík, Josef - Svatkova, Alena
PY  - 2022
TI  - Quantitative MR Markers in Non-Myelopathic Spinal Cord Compression: A Narrative Review
JF  - Journal of Clinical Medicine
VL  - 11
IS  - 9
SP  - 1-21
EP  - 1-21
PB  - MDPI
SN  - 20770383
KW  - non-myelopathic cervical spinal cord compression
KW  - degenerative cervical myelopathy
KW  - diffusion magnetic resonance imaging
KW  - quantitative magnetic resonance imaging
UR  - https://www.mdpi.com/2077-0383/11/9/2301
N2  - Degenerative spinal cord compression is a frequent pathological condition with increasing prevalence throughout aging. Initial non-myelopathic cervical spinal cord compression (NMDC) might progress over time into potentially irreversible degenerative cervical myelopathy (DCM). While quantitative MRI (qMRI) techniques demonstrated the ability to depict intrinsic tissue properties, longitudinal in-vivo biomarkers to identify NMDC patients who will eventually develop DCM are still missing. Thus, we aim to review the ability of qMRI techniques (such as diffusion MRI, diffusion tensor imaging (DTI), magnetization transfer (MT) imaging, and magnetic resonance spectroscopy (H-1-MRS)) to serve as prognostic markers in NMDC. While DTI in NMDC patients consistently detected lower fractional anisotropy and higher mean diffusivity at compressed levels, caused by demyelination and axonal injury, MT and H-1-MRS, along with advanced and tract-specific diffusion MRI, recently revealed microstructural alterations, also rostrally pointing to Wallerian degeneration. Recent studies also disclosed a significant relationship between microstructural damage and functional deficits, as assessed by qMRI and electrophysiology, respectively. Thus, tract-specific qMRI, in combination with electrophysiology, critically extends our understanding of the underlying pathophysiology of degenerative spinal cord compression and may provide predictive markers of DCM development for accurate patient management. However, the prognostic value must be validated in longitudinal studies.
ER  -

VALOSEK, Jan, Petr BEDNARIK, Miloš KEŘKOVSKÝ, Petr HLUSTIK, Josef BEDNAŘÍK a Alena SVATKOVA. Quantitative MR Markers in Non-Myelopathic Spinal Cord Compression: A Narrative Review. \textit{Journal of Clinical Medicine}. BASEL: MDPI, 2022, roč.~11, č.~9, s.~1-21. ISSN~2077-0383. Dostupné z: https://dx.doi.org/10.3390/jcm11092301.

Podrobný výpis o publikaci