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@article{2250057,
author = {Valosek, Jan and Bednarik, Petr and Keřkovský, Miloš and Hlustik, Petr and Bednařík, Josef and Svatkova, Alena},
article_location = {BASEL},
article_number = {9},
doi = {http://dx.doi.org/10.3390/jcm11092301},
keywords = {non-myelopathic cervical spinal cord compression; degenerative cervical myelopathy; diffusion magnetic resonance imaging; quantitative magnetic resonance imaging},
language = {eng},
issn = {2077-0383},
journal = {Journal of Clinical Medicine},
title = {Quantitative MR Markers in Non-Myelopathic Spinal Cord Compression: A Narrative Review},
url = {https://www.mdpi.com/2077-0383/11/9/2301},
volume = {11},
year = {2022}
}
TY - JOUR
ID - 2250057
AU - Valosek, Jan - Bednarik, Petr - Keřkovský, Miloš - Hlustik, Petr - Bednařík, Josef - Svatkova, Alena
PY - 2022
TI - Quantitative MR Markers in Non-Myelopathic Spinal Cord Compression: A Narrative Review
JF - Journal of Clinical Medicine
VL - 11
IS - 9
SP - 1-21
EP - 1-21
PB - MDPI
SN - 20770383
KW - non-myelopathic cervical spinal cord compression
KW - degenerative cervical myelopathy
KW - diffusion magnetic resonance imaging
KW - quantitative magnetic resonance imaging
UR - https://www.mdpi.com/2077-0383/11/9/2301
N2 - Degenerative spinal cord compression is a frequent pathological condition with increasing prevalence throughout aging. Initial non-myelopathic cervical spinal cord compression (NMDC) might progress over time into potentially irreversible degenerative cervical myelopathy (DCM). While quantitative MRI (qMRI) techniques demonstrated the ability to depict intrinsic tissue properties, longitudinal in-vivo biomarkers to identify NMDC patients who will eventually develop DCM are still missing. Thus, we aim to review the ability of qMRI techniques (such as diffusion MRI, diffusion tensor imaging (DTI), magnetization transfer (MT) imaging, and magnetic resonance spectroscopy (H-1-MRS)) to serve as prognostic markers in NMDC. While DTI in NMDC patients consistently detected lower fractional anisotropy and higher mean diffusivity at compressed levels, caused by demyelination and axonal injury, MT and H-1-MRS, along with advanced and tract-specific diffusion MRI, recently revealed microstructural alterations, also rostrally pointing to Wallerian degeneration. Recent studies also disclosed a significant relationship between microstructural damage and functional deficits, as assessed by qMRI and electrophysiology, respectively. Thus, tract-specific qMRI, in combination with electrophysiology, critically extends our understanding of the underlying pathophysiology of degenerative spinal cord compression and may provide predictive markers of DCM development for accurate patient management. However, the prognostic value must be validated in longitudinal studies.
ER -
VALOSEK, Jan, Petr BEDNARIK, Miloš KEŘKOVSKÝ, Petr HLUSTIK, Josef BEDNAŘÍK a Alena SVATKOVA. Quantitative MR Markers in Non-Myelopathic Spinal Cord Compression: A Narrative Review. \textit{Journal of Clinical Medicine}. BASEL: MDPI, 2022, roč.~11, č.~9, s.~1-21. ISSN~2077-0383. Dostupné z: https://dx.doi.org/10.3390/jcm11092301.
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