A New Framework for Investigating the Biological Basis of
Degenerative Cervical Myelopathy [AO Spine RECODE-DCM Research
Priority Number 5]: Mechanical Stress, Vulnerability and Time

J 2022

A New Framework for Investigating the Biological Basis of Degenerative Cervical Myelopathy [AO Spine RECODE-DCM Research Priority Number 5]: Mechanical Stress, Vulnerability and Time

DAVIES, Benjamin M, Oliver MOWFORTH, Aref-Ali GHAROONI, Lindsay TETREAULT, Aria NOURI et. al.

Základní údaje

Originální název

A New Framework for Investigating the Biological Basis of Degenerative Cervical Myelopathy [AO Spine RECODE-DCM Research Priority Number 5]: Mechanical Stress, Vulnerability and Time

Autoři

DAVIES, Benjamin M (garant), Oliver MOWFORTH, Aref-Ali GHAROONI, Lindsay TETREAULT, Aria NOURI, Rana S DHILLON, Josef BEDNAŘÍK (203 Česká republika, domácí), Allan R MARTIN, Adam YOUNG, Hitoshi TAKAHASHI, Timothy F BOERGER, Virginia F J NEWCOMBE, Carl Moritz ZIPSER, Patrick FREUND, Paul Aarne KOLJONEN, Ricardo RODRIGUES-PINTO, Vafa RAHIMI-MOVAGHAR, Jefferson R WILSON, Shekar N KURPAD, Michael G FEHLINGS, Brian K KWON, James S HARROP, James D GUEST, Armin CURT a Mark R N KOTTER

Vydání

GLOBAL SPINE JOURNAL, LONDON, SAGE PUBLICATIONS LTD, 2022, 2192-5682

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30210 Clinical neurology

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.400

Kód RIV

RIV/00216224:14110/22:00128419

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1177/21925682211057546

UT WoS

000758327200008

Klíčová slova anglicky

cervical; myelopathy; spondylosis; spondylotic; stenosis; disc herniation; ossification posterior longitudinal ligament; degeneration; disability; recovery; questionnaire

Štítky

14110221, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 31. 1. 2023 09:01, Mgr. Tereza Miškechová

Anotace

V originále

Study Design: Literature Review (Narrative) Objective: To propose a new framework, to support the investigation and understanding of the pathobiology of DCM, AO Spine RECODE-DCM research priority number 5. Methods: Degenerative cervical myelopathy is a common and disabling spinal cord disorder. In this perspective, we review key knowledge gaps between the clinical phenotype and our biological models. We then propose a reappraisal of the key driving forces behind DCM and an individual's susceptibility, including the proposal of a new framework. Results: Present pathobiological and mechanistic knowledge does not adequately explain the disease phenotype; why only a subset of patients with visualized cord compression show clinical myelopathy, and the amount of cord compression only weakly correlates with disability. We propose that DCM is better represented as a function of several interacting mechanical forces, such as shear, tension and compression, alongside an individual's vulnerability to spinal cord injury, influenced by factors such as age, genetics, their cardiovascular, gastrointestinal and nervous system status, and time. Conclusion: Understanding the disease pathobiology is a fundamental research priority. We believe a framework of mechanical stress, vulnerability, and time may better represent the disease as a whole. Whilst this remains theoretical, we hope that at the very least it will inspire new avenues of research that better encapsulate the full spectrum of disease.

Citovat

DAVIES, Benjamin M, Oliver MOWFORTH, Aref-Ali GHAROONI, Lindsay TETREAULT, Aria NOURI, Rana S DHILLON, Josef BEDNAŘÍK, Allan R MARTIN, Adam YOUNG, Hitoshi TAKAHASHI, Timothy F BOERGER, Virginia F J NEWCOMBE, Carl Moritz ZIPSER, Patrick FREUND, Paul Aarne KOLJONEN, Ricardo RODRIGUES-PINTO, Vafa RAHIMI-MOVAGHAR, Jefferson R WILSON, Shekar N KURPAD, Michael G FEHLINGS, Brian K KWON, James S HARROP, James D GUEST, Armin CURT a Mark R N KOTTER. A New Framework for Investigating the Biological Basis of Degenerative Cervical Myelopathy [AO Spine RECODE-DCM Research Priority Number 5]: Mechanical Stress, Vulnerability and Time. GLOBAL SPINE JOURNAL. LONDON: SAGE PUBLICATIONS LTD, 2022, roč. 12, 1_SUPPL, s. "78S"-"96S", 19 s. ISSN 2192-5682. Dostupné z: https://dx.doi.org/10.1177/21925682211057546.

@article{2251356,
   author = {Davies, Benjamin M and Mowforth, Oliver and Gharooni, ArefandAli and Tetreault, Lindsay and Nouri, Aria and Dhillon, Rana S and Bednařík, Josef and Martin, Allan R and Young, Adam and Takahashi, Hitoshi and Boerger, Timothy F and Newcombe, Virginia F J and Zipser, Carl Moritz and Freund, Patrick and Koljonen, Paul Aarne and RodriguesandPinto, Ricardo and RahimiandMovaghar, Vafa and Wilson, Jefferson R and Kurpad, Shekar N and Fehlings, Michael G and Kwon, Brian K and Harrop, James S and Guest, James D and Curt, Armin and Kotter, Mark R N},
   article_location = {LONDON},
   article_number = {1_SUPPL},
   doi = {http://dx.doi.org/10.1177/21925682211057546},
   keywords = {cervical; myelopathy; spondylosis; spondylotic; stenosis; disc herniation; ossification posterior longitudinal ligament; degeneration; disability; recovery; questionnaire},
   language = {eng},
   issn = {2192-5682},
   journal = {GLOBAL SPINE JOURNAL},
   title = {A New Framework for Investigating the Biological Basis of Degenerative Cervical Myelopathy [AO Spine RECODE-DCM Research Priority Number 5]: Mechanical Stress, Vulnerability and Time},
   url = {https://journals.sagepub.com/doi/10.1177/21925682211057546},
   volume = {12},
   year = {2022}
}

TY  - JOUR
ID  - 2251356
AU  - Davies, Benjamin M - Mowforth, Oliver - Gharooni, Aref-Ali - Tetreault, Lindsay - Nouri, Aria - Dhillon, Rana S - Bednařík, Josef - Martin, Allan R - Young, Adam - Takahashi, Hitoshi - Boerger, Timothy F - Newcombe, Virginia F J - Zipser, Carl Moritz - Freund, Patrick - Koljonen, Paul Aarne - Rodrigues-Pinto, Ricardo - Rahimi-Movaghar, Vafa - Wilson, Jefferson R - Kurpad, Shekar N - Fehlings, Michael G - Kwon, Brian K - Harrop, James S - Guest, James D - Curt, Armin - Kotter, Mark R N
PY  - 2022
TI  - A New Framework for Investigating the Biological Basis of Degenerative Cervical Myelopathy [AO Spine RECODE-DCM Research Priority Number 5]: Mechanical Stress, Vulnerability and Time
JF  - GLOBAL SPINE JOURNAL
VL  - 12
IS  - 1_SUPPL
SP  - "78S"-"96S"
EP  - "78S"-"96S"
PB  - SAGE PUBLICATIONS LTD
SN  - 21925682
KW  - cervical
KW  - myelopathy
KW  - spondylosis
KW  - spondylotic
KW  - stenosis
KW  - disc herniation
KW  - ossification posterior longitudinal ligament
KW  - degeneration
KW  - disability
KW  - recovery
KW  - questionnaire
UR  - https://journals.sagepub.com/doi/10.1177/21925682211057546
N2  - Study Design: Literature Review (Narrative) Objective: To propose a new framework, to support the investigation and understanding of the pathobiology of DCM, AO Spine RECODE-DCM research priority number 5. Methods: Degenerative cervical myelopathy is a common and disabling spinal cord disorder. In this perspective, we review key knowledge gaps between the clinical phenotype and our biological models. We then propose a reappraisal of the key driving forces behind DCM and an individual's susceptibility, including the proposal of a new framework. Results: Present pathobiological and mechanistic knowledge does not adequately explain the disease phenotype; why only a subset of patients with visualized cord compression show clinical myelopathy, and the amount of cord compression only weakly correlates with disability. We propose that DCM is better represented as a function of several interacting mechanical forces, such as shear, tension and compression, alongside an individual's vulnerability to spinal cord injury, influenced by factors such as age, genetics, their cardiovascular, gastrointestinal and nervous system status, and time. Conclusion: Understanding the disease pathobiology is a fundamental research priority. We believe a framework of mechanical stress, vulnerability, and time may better represent the disease as a whole. Whilst this remains theoretical, we hope that at the very least it will inspire new avenues of research that better encapsulate the full spectrum of disease.
ER  -

DAVIES, Benjamin M, Oliver MOWFORTH, Aref-Ali GHAROONI, Lindsay TETREAULT, Aria NOURI, Rana S DHILLON, Josef BEDNAŘÍK, Allan R MARTIN, Adam YOUNG, Hitoshi TAKAHASHI, Timothy F BOERGER, Virginia F J NEWCOMBE, Carl Moritz ZIPSER, Patrick FREUND, Paul Aarne KOLJONEN, Ricardo RODRIGUES-PINTO, Vafa RAHIMI-MOVAGHAR, Jefferson R WILSON, Shekar N KURPAD, Michael G FEHLINGS, Brian K KWON, James S HARROP, James D GUEST, Armin CURT a Mark R N KOTTER. A New Framework for Investigating the Biological Basis of Degenerative Cervical Myelopathy [AO Spine RECODE-DCM Research Priority Number 5]: Mechanical Stress, Vulnerability and Time. \textit{GLOBAL SPINE JOURNAL}. LONDON: SAGE PUBLICATIONS LTD, 2022, roč.~12, 1\_{}SUPPL, s.~''78S''-''96S'', 19 s. ISSN~2192-5682. Dostupné z: https://dx.doi.org/10.1177/21925682211057546.

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