Evolutionary Processes in the Emergence and Recent Spread of
the Syphilis Agent, Treponema pallidum

J 2022

Evolutionary Processes in the Emergence and Recent Spread of the Syphilis Agent, Treponema pallidum

PLA-DIAZ, Marta; Leonor SANCHEZ-BUSO; Lorenzo GIACANI; David ŠMAJS; Philipp P BOSSHARD et al.

Základní údaje

Originální název

Evolutionary Processes in the Emergence and Recent Spread of the Syphilis Agent, Treponema pallidum

Autoři

PLA-DIAZ, Marta; Leonor SANCHEZ-BUSO; Lorenzo GIACANI; David ŠMAJS; Philipp P BOSSHARD; Homayoun C BAGHERI; Verena J SCHUENEMANN; Kay NIESELT; Natasha ARORA a Fernando GONZALEZ-CANDELAS

Vydání

Molecular Biology and Evolution, Oxford, Oxford University Press, 2022, 0737-4038

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10608 Biochemistry and molecular biology

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 10.700

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/22:00129408

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

recombination; selection; phylogenetic congruence; treponematoses; genome analysis

Štítky

14110513, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 31. 1. 2023 12:45, Mgr. Tereza Miškechová

Anotace

V originále

The incidence of syphilis has risen worldwide in the last decade in spite of being an easily treated infection. The causative agent of this sexually transmitted disease is the bacterium Treponema pallidum subspecies pallidum (TPA), very closely related to subsp. pertenue (TPE) and endemicum (TEN), responsible for the human treponematoses yaws and bejel, respectively. Although much focus has been placed on the question of the spatial and temporary origins of TPA, the processes driving the evolution and epidemiological spread of TPA since its divergence from TPE and TEN are not well understood. Here, we investigate the effects of recombination and selection as forces of genetic diversity and differentiation acting during the evolution of T. pallidum subspecies. Using a custom-tailored procedure, named phylogenetic incongruence method, with 75 complete genome sequences, we found strong evidence for recombination among the T. pallidum subspecies, involving 12 genes and 21 events. In most cases, only one recombination event per gene was detected and all but one event corresponded to intersubspecies transfers, from TPE/TEN to TPA. We found a clear signal of natural selection acting on the recombinant genes, which is more intense in their recombinant regions. The phylogenetic location of the recombination events detected and the functional role of the genes with signals of positive selection suggest that these evolutionary processes had a key role in the evolution and recent expansion of the syphilis bacteria and significant implications for the selection of vaccine candidates and the design of a broadly protective syphilis vaccine.

Návaznosti

GA17-25455S, projekt VaV

Název: Studium genomů patogenních treponem na základě analýzy jednotlivých buněk

Investor: Grantová agentura ČR, Studium genomů patogenních treponem na základě analýzy jednotlivých buněk

Citovat

PLA-DIAZ, Marta; Leonor SANCHEZ-BUSO; Lorenzo GIACANI; David ŠMAJS; Philipp P BOSSHARD; Homayoun C BAGHERI; Verena J SCHUENEMANN; Kay NIESELT; Natasha ARORA a Fernando GONZALEZ-CANDELAS. Evolutionary Processes in the Emergence and Recent Spread of the Syphilis Agent, Treponema pallidum. Molecular Biology and Evolution. Oxford: Oxford University Press, 2022, roč. 39, č. 1, s. 1-14. ISSN 0737-4038. Dostupné z: https://doi.org/10.1093/molbev/msab318.

@article{2251433,
   author = {PlaandDiaz, Marta and SanchezandBuso, Leonor and Giacani, Lorenzo and Šmajs, David and Bosshard, Philipp P and Bagheri, Homayoun C and Schuenemann, Verena J and Nieselt, Kay and Arora, Natasha and GonzalezandCandelas, Fernando},
   article_location = {Oxford},
   article_number = {1},
   doi = {https://doi.org/10.1093/molbev/msab318},
   keywords = {recombination; selection; phylogenetic congruence; treponematoses; genome analysis},
   language = {eng},
   issn = {0737-4038},
   journal = {Molecular Biology and Evolution},
   title = {Evolutionary Processes in the Emergence and Recent Spread of the Syphilis Agent, Treponema pallidum},
   url = {https://academic.oup.com/mbe/article/39/1/msab318/6427636?login=true},
   volume = {39},
   year = {2022}
}

TY  - JOUR
ID  - 2251433
AU  - Pla-Diaz, Marta - Sanchez-Buso, Leonor - Giacani, Lorenzo - Šmajs, David - Bosshard, Philipp P - Bagheri, Homayoun C - Schuenemann, Verena J - Nieselt, Kay - Arora, Natasha - Gonzalez-Candelas, Fernando
PY  - 2022
TI  - Evolutionary Processes in the Emergence and Recent Spread of the Syphilis Agent, Treponema pallidum
JF  - Molecular Biology and Evolution
VL  - 39
IS  - 1
SP  - 1-14
EP  - 1-14
PB  - Oxford University Press
SN  - 07374038
KW  - recombination
KW  - selection
KW  - phylogenetic congruence
KW  - treponematoses
KW  - genome analysis
UR  - https://academic.oup.com/mbe/article/39/1/msab318/6427636?login=true
N2  - The incidence of syphilis has risen worldwide in the last decade in spite of being an easily treated infection. The causative agent of this sexually transmitted disease is the bacterium Treponema pallidum subspecies pallidum (TPA), very closely related to subsp. pertenue (TPE) and endemicum (TEN), responsible for the human treponematoses yaws and bejel, respectively. Although much focus has been placed on the question of the spatial and temporary origins of TPA, the processes driving the evolution and epidemiological spread of TPA since its divergence from TPE and TEN are not well understood. Here, we investigate the effects of recombination and selection as forces of genetic diversity and differentiation acting during the evolution of T. pallidum subspecies. Using a custom-tailored procedure, named phylogenetic incongruence method, with 75 complete genome sequences, we found strong evidence for recombination among the T. pallidum subspecies, involving 12 genes and 21 events. In most cases, only one recombination event per gene was detected and all but one event corresponded to intersubspecies transfers, from TPE/TEN to TPA. We found a clear signal of natural selection acting on the recombinant genes, which is more intense in their recombinant regions. The phylogenetic location of the recombination events detected and the functional role of the genes with signals of positive selection suggest that these evolutionary processes had a key role in the evolution and recent expansion of the syphilis bacteria and significant implications for the selection of vaccine candidates and the design of a broadly protective syphilis vaccine.
ER  -

PLA-DIAZ, Marta; Leonor SANCHEZ-BUSO; Lorenzo GIACANI; David ŠMAJS; Philipp P BOSSHARD; Homayoun C BAGHERI; Verena J SCHUENEMANN; Kay NIESELT; Natasha ARORA a Fernando GONZALEZ-CANDELAS. Evolutionary Processes in the Emergence and Recent Spread of the Syphilis Agent, Treponema pallidum. \textit{Molecular Biology and Evolution}. Oxford: Oxford University Press, 2022, roč.~39, č.~1, s.~1-14. ISSN~0737-4038. Dostupné z: https://doi.org/10.1093/molbev/msab318.

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