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@inproceedings{2252416,
author = {Nachtnebl, Luboš and Filipenský, Petr and Krechlerová, Magda and Bedáňová, Helena and Sedláková, Alena and Vajčner, Adam and Pohanka, Michal and Dobšák, Petr},
address = {Brno},
booktitle = {Masaryk University Press},
editor = {Cornélissen G., Siegelová J., Dobšák P.},
keywords = {Ionic Transport Systems; Cardiomyocytes During Hypoxia and Ischemia},
howpublished = {tištěná verze "print"},
language = {eng},
location = {Brno},
isbn = {978-80-280-0170-4},
pages = {109-119},
publisher = {Masaryk University Press},
title = {Destabilization of Ionic Transport Systems in Cardiomyocytes During Hypoxia and Ischemia},
url = {https://is.muni.cz/do/med/noninvasive_methods_in_cardiology/Noninvasive_methods_in_cardiology_2022.pdf},
year = {2022}
}
TY - JOUR
ID - 2252416
AU - Nachtnebl, Luboš - Filipenský, Petr - Krechlerová, Magda - Bedáňová, Helena - Sedláková, Alena - Vajčner, Adam - Pohanka, Michal - Dobšák, Petr
PY - 2022
TI - Destabilization of Ionic Transport Systems in Cardiomyocytes During Hypoxia and Ischemia
PB - Masaryk University Press
CY - Brno
SN - 9788028001704
KW - Ionic Transport Systems
KW - Cardiomyocytes During Hypoxia and Ischemia
UR - https://is.muni.cz/do/med/noninvasive_methods_in_cardiology/Noninvasive_methods_in_cardiology_2022.pdf
N2 - In 1994, one hundred and thirty-six years after the introduction of the term “ischemia” by Virchow, the journal Cardiovascular Research conducted a survey among eminent cardiologists to find out “their” definition of myocardial ischemia (Hearse, 1994). The results showed the responses ranged from 3 to 404 words (!). This clearly shows that a generally accepted definition does not currently exist. However, it is undisputed that ischemia is necessarily associated with changes in the energy metabolism and ionic disturbances of the myocardium. It is difficult to study ischemia experimentally and in particular in isolated muscle preparations. For this reason, many studies concerning the effects of ischemia on contractile function have used experimental protocols that reproduce only some of the metabolic, ionic and mechanical aspects of ischemia. The most used models are hypoxia or anoxia, based on partial or total suppression of oxygen (O2 ) in the perfusion medium (replacement of O2 by nitrogen or application of a reducing agent, such as sodium dithionate), or even on the use of blockers of oxidative phosphorylation (OP) such as cyanide (CN).
ER -
NACHTNEBL, Luboš, Petr FILIPENSKÝ, Magda KRECHLEROVÁ, Helena BEDÁŇOVÁ, Alena SEDLÁKOVÁ, Adam VAJČNER, Michal POHANKA a Petr DOBŠÁK. Destabilization of Ionic Transport Systems in Cardiomyocytes During Hypoxia and Ischemia. In Cornélissen G., Siegelová J., Dobšák P. \textit{Masaryk University Press}. Brno: Masaryk University Press, 2022, s.~109-119. ISBN~978-80-280-0170-4.
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