Protective Effect of Vegan Microbiota on Liver Steatosis Is
Conveyed by Dietary Fiber: Implications for Fecal Microbiota
Transfer Therapy

J 2023

Protective Effect of Vegan Microbiota on Liver Steatosis Is Conveyed by Dietary Fiber: Implications for Fecal Microbiota Transfer Therapy

DASKOVA, Nikola; Marier HECZKOVA; Istvan MODOS; Jaromir HRADECKY; Tomas HUDCOVIC et al.

Základní údaje

Originální název

Protective Effect of Vegan Microbiota on Liver Steatosis Is Conveyed by Dietary Fiber: Implications for Fecal Microbiota Transfer Therapy

Autoři

Vydání

NUTRIENTS, SWITZERLAND, MDPI, 2023, 2072-6643

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30308 Nutrition, Dietetics

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.800

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14560/23:00130325

Organizační jednotka

Ekonomicko-správní fakulta

Klíčová slova anglicky

fecal microbiota transfer; vegan microbiota; liver steatosis; inulin; proteolytic fermentation

Příznaky

Recenzováno

Změněno: 15. 9. 2023 09:04, Mgr. Pavlína Kurková

Anotace

V originále

Fecal microbiota transfer may serve as a therapeutic tool for treating obesity and related disorders but currently, there is no consensus regarding the optimal donor characteristics. We studied how microbiota from vegan donors, who exhibit a low incidence of non-communicable diseases, impact on metabolic effects of an obesogenic diet and the potential role of dietary inulin in mediating these effects. Ex-germ-free animals were colonized with human vegan microbiota and fed a standard or Western-type diet (WD) with or without inulin supplementation. Despite the colonization with vegan microbiota, WD induced excessive weight gain, impaired glucose metabolism, insulin resistance, and liver steatosis. However, supplementation with inulin reversed steatosis and improved glucose homeostasis. In contrast, inulin did not affect WD-induced metabolic changes in non-humanized conventional mice. In vegan microbiota-colonized mice, inulin supplementation resulted in a significant change in gut microbiota composition and its metabolic performance, inducing the shift from proteolytic towards saccharolytic fermentation (decrease of sulfur-containing compounds, increase of SCFA). We found that (i) vegan microbiota alone does not protect against adverse effects of WD; and (ii) supplementation with inulin reversed steatosis and normalized glucose metabolism. This phenomenon is associated with the shift in microbiota composition and accentuation of saccharolytic fermentation at the expense of proteolytic fermentation

Návaznosti

LX22NPO5104, projekt VaV

Název: Národní institut pro výzkum metabolických a kardiovaskulárních onemocnění (Akronym: CarDia)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Národní institut pro léčbu metabolických a kardiovaskulárních onemocnění, 5.1 EXCELES

Přiložené soubory

nutrients-15-00454__1_.pdf

Citovat

DASKOVA, Nikola; Marier HECZKOVA; Istvan MODOS; Jaromir HRADECKY; Tomas HUDCOVIC; Marek KUZMA; Helena PELANTOVA; Irena BUSKOVA; Eva STICOVA; David FUNDA; Jaroslav GOLIAS; Barbora DRABONOVA; Jarmila JARKOVSKA; Maria KRÁLOVÁ; Ivana CIBULKOVA; Jan GOJDA a Monika CAHOVÁ. Protective Effect of Vegan Microbiota on Liver Steatosis Is Conveyed by Dietary Fiber: Implications for Fecal Microbiota Transfer Therapy. NUTRIENTS. SWITZERLAND: MDPI, 2023, roč. 15, č. 2, s. 454-471. ISSN 2072-6643. Dostupné z: https://doi.org/10.3390/nu15020454.

@article{2254871,
   author = {Daskova, Nikola and Heczkova, Marier and Modos, Istvan and Hradecky, Jaromir and Hudcovic, Tomas and Kuzma, Marek and Pelantova, Helena and Buskova, Irena and Sticova, Eva and Funda, David and Golias, Jaroslav and Drabonova, Barbora and Jarkovska, Jarmila and Králová, Maria and Cibulkova, Ivana and Gojda, Jan and Cahová, Monika},
   article_location = {SWITZERLAND},
   article_number = {2},
   doi = {https://doi.org/10.3390/nu15020454},
   keywords = {fecal microbiota transfer; vegan microbiota; liver steatosis; inulin; proteolytic fermentation},
   language = {eng},
   issn = {2072-6643},
   journal = {NUTRIENTS},
   title = {Protective Effect of Vegan Microbiota on Liver Steatosis Is Conveyed by Dietary Fiber: Implications for Fecal Microbiota Transfer Therapy},
   url = {https://www.mdpi.com/2072-6643/15/2/454},
   volume = {15},
   year = {2023}
}

TY  - JOUR
ID  - 2254871
AU  - Daskova, Nikola - Heczkova, Marier - Modos, Istvan - Hradecky, Jaromir - Hudcovic, Tomas - Kuzma, Marek - Pelantova, Helena - Buskova, Irena - Sticova, Eva - Funda, David - Golias, Jaroslav - Drabonova, Barbora - Jarkovska, Jarmila - Králová, Maria - Cibulkova, Ivana - Gojda, Jan - Cahová, Monika
PY  - 2023
TI  - Protective Effect of Vegan Microbiota on Liver Steatosis Is Conveyed by Dietary Fiber: Implications for Fecal Microbiota Transfer Therapy
JF  - NUTRIENTS
VL  - 15
IS  - 2
SP  - 454
EP  - 454
PB  - MDPI
SN  - 20726643
KW  - fecal microbiota transfer
KW  - vegan microbiota
KW  - liver steatosis
KW  - inulin
KW  - proteolytic fermentation
UR  - https://www.mdpi.com/2072-6643/15/2/454
N2  - Fecal microbiota transfer may serve as a therapeutic tool for treating obesity and related disorders but currently, there is no consensus regarding the optimal donor characteristics. We studied how microbiota from vegan donors, who exhibit a low incidence of non-communicable diseases, impact on metabolic effects of an obesogenic diet and the potential role of dietary inulin in mediating these effects. Ex-germ-free animals were colonized with human vegan microbiota and fed a standard or Western-type diet (WD) with or without inulin supplementation. Despite the colonization with vegan microbiota, WD induced excessive weight gain, impaired glucose metabolism, insulin resistance, and liver steatosis. However, supplementation with inulin reversed steatosis and improved glucose homeostasis. In contrast, inulin did not affect WD-induced metabolic changes in non-humanized conventional mice. In vegan microbiota-colonized mice, inulin supplementation resulted in a significant change in gut microbiota composition and its metabolic performance, inducing the shift from proteolytic towards saccharolytic fermentation (decrease of sulfur-containing compounds, increase of SCFA). We found that (i) vegan microbiota alone does not protect against adverse effects of WD; and (ii) supplementation with inulin reversed steatosis and normalized glucose metabolism. This phenomenon is associated with the shift in microbiota composition and accentuation of saccharolytic fermentation at the expense of proteolytic fermentation
ER  -

DASKOVA, Nikola; Marier HECZKOVA; Istvan MODOS; Jaromir HRADECKY; Tomas HUDCOVIC; Marek KUZMA; Helena PELANTOVA; Irena BUSKOVA; Eva STICOVA; David FUNDA; Jaroslav GOLIAS; Barbora DRABONOVA; Jarmila JARKOVSKA; Maria KRÁLOVÁ; Ivana CIBULKOVA; Jan GOJDA a Monika CAHOVÁ. Protective Effect of Vegan Microbiota on Liver Steatosis Is Conveyed by Dietary Fiber: Implications for Fecal Microbiota Transfer Therapy. \textit{NUTRIENTS}. SWITZERLAND: MDPI, 2023, roč.~15, č.~2, s.~454-471. ISSN~2072-6643. Dostupné z: https://doi.org/10.3390/nu15020454.

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