2023
Peripheral Inflammatory Markers in Subtypes and Core Features of Depression: A Systematized Review
KŘENEK, Pavel; Jana HOŘÍNKOVÁ a Eliška BARTEČKOVÁZákladní údaje
Originální název
Peripheral Inflammatory Markers in Subtypes and Core Features of Depression: A Systematized Review
Autoři
KŘENEK, Pavel; Jana HOŘÍNKOVÁ a Eliška BARTEČKOVÁ
Vydání
PSYCHOPATHOLOGY, BASEL, KARGER, 2023, 0254-4962
Další údaje
Jazyk
angličtina
Typ výsledku
Článek v odborném periodiku
Obor
30215 Psychiatry
Stát vydavatele
Švýcarsko
Utajení
není předmětem státního či obchodního tajemství
Impakt faktor
Impact factor: 1.900
Označené pro přenos do RIV
Ano
Kód RIV
RIV/00216224:14110/23:00130366
Organizační jednotka
Lékařská fakulta
UT WoS
EID Scopus
Klíčová slova anglicky
Adipokines; Cytokines; Depression; Endophenotypes; Inflammation
Příznaky
Mezinárodní význam, Recenzováno
Změněno: 14. 2. 2024 09:25, Mgr. Tereza Miškechová
Anotace
V originále
Introduction: The aim of this work was to summarize relationships between two subtypes of major depressive disorder (melancholic and atypical) and four core features of depression that reflect the domains identified consistently in previous studies of major depressive disorder endophenotypes (exaggerated reactivity to negative information, altered reward processing, cognitive control deficits, and somatic symptoms) on the one hand and selected peripheral inflammatory markers (C-reactive protein [CRP], cytokines, and adipokines) on the other. Methods: A systematized review was conducted. The database used for searching articles was PubMed (MEDLINE). Results: According to our search, most peripheral immunological markers associated with major depressive disorder are not specific to a single depressive symptom group. The most evident examples are CRP, IL-6, and TNF-α. The strongest evidence supports the connection of peripheral inflammatory markers with somatic symptoms; weaker evidence indicates a role of immune changes in altered reward processing. The least amount of evidence was found for the role of peripheral inflammatory markers in exaggerated reactivity to negative information and cognitive control deficits. Regarding the depression subtypes, a tendency for higher CRP and adipokines was observed in atypical depression; increased IL-6 was found in melancholic depression. Conclusion: Somatic symptoms of depression could be a manifestation of a specific immunological endophenotype of depressive disorder. Melancholic and atypical depression may be characterized by different profiles of immunological markers.
Návaznosti
| LX22NPO5107, projekt VaV |
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| MUNI/A/1399/2022, interní kód MU |
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| ROZV/28/LF/2020, interní kód MU |
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