Transient Reflexive Pain Responses and Chronic Affective
Nonreflexive Pain Responses Associated with Neuroinflammation
Processes in Both Spinal and Supraspinal Structures in Spinal
Cord-Injured Female Mice

J 2023

Transient Reflexive Pain Responses and Chronic Affective Nonreflexive Pain Responses Associated with Neuroinflammation Processes in Both Spinal and Supraspinal Structures in Spinal Cord-Injured Female Mice

CASTANY, Sílvia; Anna BAGÓ MAS; José MIGUEL VELA; Enrique VERDÚ; Karolína BRETOVÁ et al.

Základní údaje

Originální název

Transient Reflexive Pain Responses and Chronic Affective Nonreflexive Pain Responses Associated with Neuroinflammation Processes in Both Spinal and Supraspinal Structures in Spinal Cord-Injured Female Mice

Autoři

CASTANY, Sílvia; Anna BAGÓ MAS; José MIGUEL VELA; Enrique VERDÚ; Karolína BRETOVÁ; Viktorie SVOBODOVÁ; Petr DUBOVÝ a Pere BOADAS-VAELLO

Vydání

International Journal of Molecular Sciences, Basel, MDPI, 2023, 1422-0067

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30106 Anatomy and morphology

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/23:00130444

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

spinal cord injury; central neuropathic pain; chronic pain; neuroinflammation; cytokines; chemokines; gliosis; CX3CL1/CX3CR1

Štítky

14110514, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 26. 1. 2024 11:18, Mgr. Tereza Miškechová

Anotace

V originále

Central neuropathic pain is not only characterized by reflexive pain responses, but also emotional or affective nonreflexive pain responses, especially in women. Some pieces of evidence suggest that the activation of the neuroimmune system may be contributing to the manifestation of mood disorders in patients with chronic pain conditions, but the mechanisms that contribute to the development and chronicity of CNP and its associated disorders remain poorly understood. This study aimed to determine whether neuroinflammatory factor over-expression in the spinal cord and supraspinal structures may be associated with reflexive and nonreflexive pain response development from acute SCI phase to 12 weeks post-injury in female mice. The results show that transient reflexive responses were observed during the SCI acute phase associated with transient cytokine overexpression in the spinal cord. In contrast, increased nonreflexive pain responses were observed in the chronic phase associated with cytokine overexpression in supraspinal structures, especially in mPFC. In addition, results revealed that besides cytokines, the mPFC showed an increased glial activation as well as CX3CL1/CX3CR1 upregulation in the neurons, suggesting the contribution of neuron-glia crosstalk in the development of nonreflexive pain responses in the chronic spinal cord injury phase.

Citovat

CASTANY, Sílvia; Anna BAGÓ MAS; José MIGUEL VELA; Enrique VERDÚ; Karolína BRETOVÁ; Viktorie SVOBODOVÁ; Petr DUBOVÝ a Pere BOADAS-VAELLO. Transient Reflexive Pain Responses and Chronic Affective Nonreflexive Pain Responses Associated with Neuroinflammation Processes in Both Spinal and Supraspinal Structures in Spinal Cord-Injured Female Mice. International Journal of Molecular Sciences. Basel: MDPI, 2023, roč. 24, č. 2, s. 1-23. ISSN 1422-0067. Dostupné z: https://doi.org/10.3390/ijms24021761.

@article{2267258,
   author = {Castany, Sílvia and Bagó Mas, Anna and Miguel Vela, José and Verdú, Enrique and Bretová, Karolína and Svobodová, Viktorie and Dubový, Petr and BoadasandVaello, Pere},
   article_location = {Basel},
   article_number = {2},
   doi = {https://doi.org/10.3390/ijms24021761},
   keywords = {spinal cord injury; central neuropathic pain; chronic pain; neuroinflammation; cytokines; chemokines; gliosis; CX3CL1/CX3CR1},
   language = {eng},
   issn = {1422-0067},
   journal = {International Journal of Molecular Sciences},
   title = {Transient Reflexive Pain Responses and Chronic Affective Nonreflexive Pain Responses Associated with Neuroinflammation Processes in Both Spinal and Supraspinal Structures in Spinal Cord-Injured Female Mice},
   url = {https://doi.org/10.3390/ijms24021761},
   volume = {24},
   year = {2023}
}

TY  - JOUR
ID  - 2267258
AU  - Castany, Sílvia - Bagó Mas, Anna - Miguel Vela, José - Verdú, Enrique - Bretová, Karolína - Svobodová, Viktorie - Dubový, Petr - Boadas-Vaello, Pere
PY  - 2023
TI  - Transient Reflexive Pain Responses and Chronic Affective Nonreflexive Pain Responses Associated with Neuroinflammation Processes in Both Spinal and Supraspinal Structures in Spinal Cord-Injured Female Mice
JF  - International Journal of Molecular Sciences
VL  - 24
IS  - 2
SP  - 1-23
EP  - 1-23
PB  - MDPI
SN  - 14220067
KW  - spinal cord injury
KW  - central neuropathic pain
KW  - chronic pain
KW  - neuroinflammation
KW  - cytokines
KW  - chemokines
KW  - gliosis
KW  - CX3CL1/CX3CR1
UR  - https://doi.org/10.3390/ijms24021761
N2  - Central neuropathic pain is not only characterized by reflexive pain responses, but also emotional or affective nonreflexive pain responses, especially in women. Some pieces of evidence suggest that the activation of the neuroimmune system may be contributing to the manifestation of mood disorders in patients with chronic pain conditions, but the mechanisms that contribute to the development and chronicity of CNP and its associated disorders remain poorly understood. This study aimed to determine whether neuroinflammatory factor over-expression in the spinal cord and supraspinal structures may be associated with reflexive and nonreflexive pain response development from acute SCI phase to 12 weeks post-injury in female mice. The results show that transient reflexive responses were observed during the SCI acute phase associated with transient cytokine overexpression in the spinal cord. In contrast, increased nonreflexive pain responses were observed in the chronic phase associated with cytokine overexpression in supraspinal structures, especially in mPFC. In addition, results revealed that besides cytokines, the mPFC showed an increased glial activation as well as CX3CL1/CX3CR1 upregulation in the neurons, suggesting the contribution of neuron-glia crosstalk in the development of nonreflexive pain responses in the chronic spinal cord injury phase.
ER  -

CASTANY, Sílvia; Anna BAGÓ MAS; José MIGUEL VELA; Enrique VERDÚ; Karolína BRETOVÁ; Viktorie SVOBODOVÁ; Petr DUBOVÝ a Pere BOADAS-VAELLO. Transient Reflexive Pain Responses and Chronic Affective Nonreflexive Pain Responses Associated with Neuroinflammation Processes in Both Spinal and Supraspinal Structures in Spinal Cord-Injured Female Mice. \textit{International Journal of Molecular Sciences}. Basel: MDPI, 2023, roč.~24, č.~2, s.~1-23. ISSN~1422-0067. Dostupné z: https://doi.org/10.3390/ijms24021761.

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