2023
Spray-dried microparticles containing ciprofloxacin for pulmonary delivery
PEŠTÁLOVÁ, Andrea; Sylvie PAVLOKOVÁ a Jan GAJDZIOKZákladní údaje
Originální název
Spray-dried microparticles containing ciprofloxacin for pulmonary delivery
Autoři
Vydání
Student scientific conference MUNI PHARM 2023, 2023
Další údaje
Jazyk
angličtina
Typ výsledku
Prezentace na konferencích
Obor
30104 Pharmacology and pharmacy
Stát vydavatele
Česká republika
Utajení
není předmětem státního či obchodního tajemství
Označené pro přenos do RIV
Ano
Kód RIV
RIV/00216224:14160/23:00130642
Organizační jednotka
Farmaceutická fakulta
Klíčová slova česky
mikročástice; sprejové sušení; ciprofloxacin; cystická fibróza
Klíčová slova anglicky
microparticles; spray drying; ciprofloxacin; cystic fibrosis
Změněno: 7. 11. 2023 12:49, JUDr. Sabina Gajdzioková
Anotace
V originále
Inhalation therapy of cystic fibrosis using a dry powder inhaler (DPI) is currently being studied in many clinical trials. One possible treatment option is the administration of fluroqinolones in the treatment of P. aeruginosa infections and have been proven to reduce the bacterial load in the lungs and improve patients’ lung function. In order for antibiotic therapy to be effective, the formulation should focus on the parameters particles should have, especially their size and shape, porosity or aerosolisation properties. For the formulation of dry powders, the most common are spray technologies and also the addition of excipients such as porogens or substances from the amino acid group can modify the resulting properties. The aim was to optimize the drying conditions to produce aerodynamically suitable particles. In the next step, particles containing ciprofloxacin were formulated. The resulting particles were evaluated in terms of morphology, flow properties and geometric or aerodynamic diameter respectively.
Návaznosti
| MUNI/A/1140/2021, interní kód MU |
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