J 2023

Age-Related Effects of COVID-19 Pandemic on Mechanical Reperfusion and 30-Day Mortality for STEMI: Results of the ISACS-STEMI COVID-19 Registry

GIUSEPPE, De Luca; Magdy ALGOWHARY; Berat UGUZ; Dinaldo C OLIVEIRA; Vladimir GANYUKOV et. al.

Základní údaje

Originální název

Age-Related Effects of COVID-19 Pandemic on Mechanical Reperfusion and 30-Day Mortality for STEMI: Results of the ISACS-STEMI COVID-19 Registry

Autoři

GIUSEPPE, De Luca (garant); Magdy ALGOWHARY; Berat UGUZ; Dinaldo C OLIVEIRA; Vladimir GANYUKOV; Oliver BUSLJETIK; Miha CERCEK; Lisette Okkels JENSEN; Poay Huan LOH; Lucian CALMAC; Gerard Roura i FERRER; Alexandre QUADROS; Marek MILEWSKI; Fortunato Scotto UCCIO; von Birgelen CLEMENS; Francesco VERSACI; Ten Berg JURRIEN; Gianni CASELLA; Aaron Wong Sung LUNG; Petr KALA (203 Česká republika, domácí); Jose Luis Diez GIL; Xavier CARRILLO; Maurits DIRKSEN; Victor Becerra MUNOZ; Michael Kang-yin LEE; Dafsah Arifa JUZAR; Rodrigo de Joaquim JOAQUIM; Roberto PALADINO; Davor MILICIC; Periklis DAVLOUROS; Nikola BAKRACESKI; Filippo ZILIO; Luca DONAZZAN; Adriaan KRAAIJEVELD; Gennaro GALASSO; Lux ARPAD; Lucia MARINUCCI; Vincenzo GUIDUCCI; Maurizio MENICHELLI; Alessandra SCOCCIA; Aylin Hatice YAMAC; Kadir Ugur MERT; Xacobe Flores RIOS; Tomas KOVARNIK; Michal KIDAWA; Jose MOREU; Vincent FLAVIEN; Enrico FABRIS; Inigo Lozano MARTINEZ-LUENGAS; Marco BOCCALATTE; Francisco Bosa OJEDA; Carlos ARELLANO-SERRANO; Gianluca CAIAZZO; Giuseppe CIRRINCIONE; Hsien-Li KAO; Juan Sanchis FORES; Luigi VIGNALI; Helder PEREIRA; Stephane MANZO-SILBERMAN; Santiago ORDONEZ; Arat Ozkan ALEV; Bruno SCHELLER; Heidi LEHITOLA; Rui TELES; Christos MANTIS; Ylitalo ANTTI; Joao Antonio Brum SILVEIRA; Cesar Rodrigo ZONI; Ivan BESSONOV; Giuseppe UCCELLO; George KOCHIADAKIS; Dimitrios ALEXOPULOS; Carlos E URIBE; John KANAKAKIS; Benjamin FAURIE; Gabriele GABRIELLI; Alejandro Gutierrez BARRIOS; Juan Pablo BACHINI; Alex ROCHA; Frankie C C TAM; Alfredo RODRIGUEZ; Antonia Anna LUKITO; Veauthyelau SAINT-JOY; Gustavo PESSAH; Andrea TUCCILLO; Alfonso IELASI; Giuliana CORTESE; Guido PARODI; Mohammed Abed BURGADHA; Elvin KEDHI; Pablo LAMELAS; Harry SURYAPRANATA; Matteo NARDIN a Monica VERDOIA

Vydání

Journal of Clinical Medicine, Basel, MDPI, 2023, 2077-0383

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30201 Cardiac and Cardiovascular systems

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

Impakt faktor

Impact factor: 3.000

Kód RIV

RIV/00216224:14110/23:00131025

Organizační jednotka

Lékařská fakulta

UT WoS

000973288800001

EID Scopus

2-s2.0-85158077965

Klíčová slova anglicky

ageing; ST-segment elevation myocardial infarction; COVID-19

Štítky

Příznaky

Mezinárodní význam, Recenzováno
Změněno: 21. 6. 2023 09:57, Mgr. Tereza Miškechová

Anotace

V originále

Background: The constraints in the management of patients with ST-segment elevation myocardial infarction (STEMI) during the COVID-19 pandemic have been suggested to have severely impacted mortality levels. The aim of the current analysis is to evaluate the age-related effects of the COVID-19 pandemic on mechanical reperfusion and 30-day mortality for STEMI within the registry ISACS-STEMI COVID-19. Methods: This retrospective multicenter registry was performed in high-volume PPCI centers on four continents and included STEMI patients undergoing PPCI in March-June 2019 and 2020. Patients were divided according to age (< or >= 75 years). The main outcomes were the incidence and timing of PPCI, (ischemia time longer than 12 h and door-to-balloon longer than 30 min), and in-hospital or 30-day mortality. Results: We included 16,683 patients undergoing PPCI in 109 centers. In 2020, during the pandemic, there was a significant reduction in PPCI as compared to 2019 (IRR 0.843 (95%-CI: 0.825-0.861, p < 0.0001). We found a significant age-related reduction (7%, p = 0.015), with a larger effect on elderly than on younger patients. Furthermore, we observed significantly higher 30-day mortality during the pandemic period, especially among the elderly (13.6% vs. 17.9%, adjusted HR (95% CI) = 1.55 [1.24-1.93], p < 0.001) as compared to younger patients (4.8% vs. 5.7%; adjusted HR (95% CI) = 1.25 [1.05-1.49], p = 0.013), as a potential consequence of the significantly longer ischemia time observed during the pandemic. Conclusions: The COVID-19 pandemic had a significant impact on the treatment of patients with STEMI, with a 16% reduction in PPCI procedures, with a larger reduction and a longer delay to treatment among elderly patients, which may have contributed to increase in-hospital and 30-day mortality during the pandemic.