Cancer-associated fibroblasts: Mediators of head and neck tumor
microenvironment remodeling

J 2023

Cancer-associated fibroblasts: Mediators of head and neck tumor microenvironment remodeling

RAUDENSKÁ, Martina; Jan BALVAN; Klára HÁNĚLOVÁ; Mária BUGAJOVÁ; Michal MASAŘÍK et al.

Základní údaje

Originální název

Cancer-associated fibroblasts: Mediators of head and neck tumor microenvironment remodeling

Autoři

RAUDENSKÁ, Martina ; Jan BALVAN; Klára HÁNĚLOVÁ; Mária BUGAJOVÁ a Michal MASAŘÍK

Vydání

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, AMSTERDAM, ELSEVIER, 2023, 0304-419X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30204 Oncology

Stát vydavatele

Nizozemské království

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 9.700

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/23:00131127

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

Head and neck cancer; Cancer-associated fibroblasts; Cancer therapy; Tumor microenvironment; Resistance to therapy

Štítky

14110515, 14110518, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 25. 1. 2024 14:00, Mgr. Tereza Miškechová

Anotace

V originále

Cancer-associated fibroblasts (CAFs) are involved in critical aspects of head and neck squamous cell carcinoma (HNSCC) pathogenesis, such as the formation of a tumor-permissive extracellular matrix structure, angiogenesis, or immune and metabolic reprogramming of the tumor microenvironment (TME), with implications for metastasis and resistance to radiotherapy and chemotherapy. The pleiotropic effect of CAFs in TME is likely to reflect the heterogeneity and plasticity of their population, with context-dependent effects on carcinogenesis. The specific properties of CAFs provide many targetable molecules that could play an important role in the future therapy of HNSCC. In this review article, we will focus on the role of CAFs in the TME of HNSCC tumors. We will also discuss clinically relevant agents targeting CAFs, their signals, and signaling pathways, which are activated by CAFs in cancer cells, with the potential for repurposing for HNSCC therapy.

Návaznosti

GA21-06873S, projekt VaV

Název: Metabolická symbióza mezi nádorovými buňkami a fibroblasty asociovaných s nádorem u nádorů v oblasti hlavy a krku

Investor: Grantová agentura ČR, Metabolic symbiosis between cancer cells and cancer-associated fibroblasts in head and neck cancer

MUNI/A/1343/2022, interní kód MU

Název: Zátěže kardiovaskulárního systému od A po Z

Investor: Masarykova univerzita, Zátěže kardiovaskulárního systému od A po Z

MUNI/A/1370/2022, interní kód MU

Název: Patofyziologie vybraných komplexních nemocí od molekulární do systémovou úroveň

Investor: Masarykova univerzita, Patofyziologie vybraných komplexních nemocí od molekulární do systémovou úroveň

NU22-03-00202, projekt VaV

Název: Proteom extracelulárních vezikul - neprozkoumaná oblast mezibuněčné komunikace v mikroprostředí nádorů hlavy a krku

Investor: Ministerstvo zdravotnictví ČR, Proteom extracelulárních vezikul - neprozkoumaná oblast mezibuněčné komunikace v mikroprostředí nádorů hlavy a krku, Podprogram 1 - standardní

Citovat

RAUDENSKÁ, Martina; Jan BALVAN; Klára HÁNĚLOVÁ; Mária BUGAJOVÁ a Michal MASAŘÍK. Cancer-associated fibroblasts: Mediators of head and neck tumor microenvironment remodeling. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer. AMSTERDAM: ELSEVIER, 2023, roč. 1878, č. 5, s. 1-12. ISSN 0304-419X. Dostupné z: https://doi.org/10.1016/j.bbcan.2023.188940.

@article{2294958,
   author = {Raudenská, Martina and Balvan, Jan and Hánělová, Klára and Bugajová, Mária and Masařík, Michal},
   article_location = {AMSTERDAM},
   article_number = {5},
   doi = {https://doi.org/10.1016/j.bbcan.2023.188940},
   keywords = {Head and neck cancer; Cancer-associated fibroblasts; Cancer therapy; Tumor microenvironment; Resistance to therapy},
   language = {eng},
   issn = {0304-419X},
   journal = {Biochimica et Biophysica Acta (BBA) - Reviews on Cancer},
   title = {Cancer-associated fibroblasts: Mediators of head and neck tumor microenvironment remodeling},
   url = {https://www.sciencedirect.com/science/article/pii/S0304419X23000896?via%3Dihub},
   volume = {1878},
   year = {2023}
}

TY  - JOUR
ID  - 2294958
AU  - Raudenská, Martina - Balvan, Jan - Hánělová, Klára - Bugajová, Mária - Masařík, Michal
PY  - 2023
TI  - Cancer-associated fibroblasts: Mediators of head and neck tumor microenvironment remodeling
JF  - Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
VL  - 1878
IS  - 5
SP  - 1-12
EP  - 1-12
PB  - ELSEVIER
SN  - 0304419X
KW  - Head and neck cancer
KW  - Cancer-associated fibroblasts
KW  - Cancer therapy
KW  - Tumor microenvironment
KW  - Resistance to therapy
UR  - https://www.sciencedirect.com/science/article/pii/S0304419X23000896?via%3Dihub
N2  - Cancer-associated fibroblasts (CAFs) are involved in critical aspects of head and neck squamous cell carcinoma (HNSCC) pathogenesis, such as the formation of a tumor-permissive extracellular matrix structure, angiogenesis, or immune and metabolic reprogramming of the tumor microenvironment (TME), with implications for metastasis and resistance to radiotherapy and chemotherapy. The pleiotropic effect of CAFs in TME is likely to reflect the heterogeneity and plasticity of their population, with context-dependent effects on carcinogenesis. The specific properties of CAFs provide many targetable molecules that could play an important role in the future therapy of HNSCC. In this review article, we will focus on the role of CAFs in the TME of HNSCC tumors. We will also discuss clinically relevant agents targeting CAFs, their signals, and signaling pathways, which are activated by CAFs in cancer cells, with the potential for repurposing for HNSCC therapy.
ER  -

RAUDENSKÁ, Martina; Jan BALVAN; Klára HÁNĚLOVÁ; Mária BUGAJOVÁ a Michal MASAŘÍK. Cancer-associated fibroblasts: Mediators of head and neck tumor microenvironment remodeling. \textit{Biochimica et Biophysica Acta (BBA) - Reviews on Cancer}. AMSTERDAM: ELSEVIER, 2023, roč.~1878, č.~5, s.~1-12. ISSN~0304-419X. Dostupné z: https://doi.org/10.1016/j.bbcan.2023.188940.

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