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@article{2295490,
author = {Runkel, Agneta A. and Stajnko, Anja and Tratnik, Janja Snoj and Mazej, Darja and Horvat, Milena and Přibylová, Petra and Kosjek, Tina},
article_location = {OXFORD},
article_number = {April 2023},
doi = {http://dx.doi.org/10.1016/j.chemosphere.2023.138096},
keywords = {PFAS; Human biomonitoring; Exposure assessment; Children; Serum; Slovenia},
language = {eng},
issn = {0045-6535},
journal = {Chemosphere},
title = {Exposure of children and adolescents from Northeastern Slovenia to per- and polyfluoroalkyl substances},
url = {https://www.sciencedirect.com/science/article/pii/S0045653523003636?via%3Dihub},
volume = {321},
year = {2023}
}
TY - JOUR
ID - 2295490
AU - Runkel, Agneta A. - Stajnko, Anja - Tratnik, Janja Snoj - Mazej, Darja - Horvat, Milena - Přibylová, Petra - Kosjek, Tina
PY - 2023
TI - Exposure of children and adolescents from Northeastern Slovenia to per- and polyfluoroalkyl substances
JF - Chemosphere
VL - 321
IS - April 2023
SP - 1-11
EP - 1-11
PB - PERGAMON-ELSEVIER SCIENCE LTD
SN - 00456535
KW - PFAS
KW - Human biomonitoring
KW - Exposure assessment
KW - Children
KW - Serum
KW - Slovenia
UR - https://www.sciencedirect.com/science/article/pii/S0045653523003636?via%3Dihub
N2 - Per-and polyfluoroalkyl substances (PFAS) are of high concern for the environment, wildlife, and human health due to their persistence and potential to cause adverse health effects. Despite political measures to restrict the production and distribution of PFAS and to limit the exposure of populations, PFAS can be measured at commonly high detection frequencies in human samples.Thus, this pilot study aimed to determine the serum concentrations of PFPA, PFHpA, PFOA, PFNA, PFDA, PFUnDA, PFHxS, PFHpS, PFOS, PFHxA, PFDoDA, and PFBS in 113 girls and 112 boys (age 7-10 and 12-15) from Northeastern Slovenia -a rural area characterized by agricultural activities -and to identify potential sources of exposure using questionnaire data. PFAS were analysed by liquid chromatography coupled to mass spectrometry after phospholipid removal.9 out of 12 analytes were detected at detection frequencies above 30%, with the highest geometric means (GM) being observed for PFOS (GM 1.9 ng/mL) > PFOA (GM 1.0 ng/mL) > PFHxS (GM 0.3 ng/mL) symbolscript PFNA (GM 0.3 ng/mL). We identified the participants' socio-economic status, age, sex, sampling region, public water supply, and the consumption of fish and seafood, cereals, and locally produced fruits, vegetables, and mushrooms as the predominant determinants of exposure. Furthermore, we compared our results with the serum and plasma concentrations reported for similar age groups in other studies and concluded that PFAS exposure in this highly agricultural area in Slovenia is notably low. This is the first study systematic HBM study of PFAS exposure in Slovenia, although it was conducted on a limited number of participants representative of rural and agricultural areas, it represents a good basis for upgrading the approach to a nationwide HBM study.
ER -
RUNKEL, Agneta A., Anja STAJNKO, Janja Snoj TRATNIK, Darja MAZEJ, Milena HORVAT, Petra PŘIBYLOVÁ a Tina KOSJEK. Exposure of children and adolescents from Northeastern Slovenia to per- and polyfluoroalkyl substances. \textit{Chemosphere}. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD, 2023, roč.~321, April 2023, s.~1-11. ISSN~0045-6535. Dostupné z: https://dx.doi.org/10.1016/j.chemosphere.2023.138096.
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