Non-Invasive Diagnostics of Male Spermatogenesis from Seminal
Plasma: Seminal Proteins

J 2023

Non-Invasive Diagnostics of Male Spermatogenesis from Seminal Plasma: Seminal Proteins

JEŠETA, Michal, Anna POSPÍŠILOVÁ, Lenka MEKIŇOVÁ, Kateřina FRANZOVÁ, Pavel VENTRUBA et. al.

Základní údaje

Originální název

Non-Invasive Diagnostics of Male Spermatogenesis from Seminal Plasma: Seminal Proteins

Autoři

JEŠETA, Michal (203 Česká republika, domácí), Anna POSPÍŠILOVÁ (203 Česká republika, domácí), Lenka MEKIŇOVÁ (703 Slovensko, domácí), Kateřina FRANZOVÁ (203 Česká republika, domácí), Pavel VENTRUBA (203 Česká republika, domácí), Eva LOUSOVÁ (203 Česká republika, domácí), Bartosz KEMPISTY (616 Polsko), Tomáš OŽDIAN (203 Česká republika), Jana ŽÁKOVÁ (203 Česká republika, domácí) a Igor CRHA (203 Česká republika, domácí)

Vydání

Diagnostics, Basel, MDPI, 2023, 2075-4418

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30214 Obstetrics and gynaecology

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.600 v roce 2022

Kód RIV

RIV/00216224:14110/23:00131350

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.3390/diagnostics13152468

UT WoS

001045385400001

Klíčová slova anglicky

spermatozoa; azoospermia; sperm isolation; sperm analyses

Štítky

14110240, 14110611, podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 4. 3. 2024 09:59, Mgr. Tereza Miškechová

Anotace

V originále

The compounds of seminal plasma have great potential as biomarkers of male fertility and can be used as a diagnostic tool for types of azoospermia. Azoospermia occurs in approximately 1% of the male population, and for an effective therapy of this form of male infertility, it is important to distinguish between obstructive and non-obstructive azoospermia. Proteins in seminal plasma can serve as biomarkers for diagnosing azoospermia. Considering the various types of obstructions, a combination of multiple proteins is advisable for diagnostic purposes. In this context, testicular and epididymal proteins are particularly significant, as they are specific to these tissues and typically absent in ejaculate during most obstructions. A combination of multiple biomarkers is more effective than the analysis of a single protein. This group of markers contains TEX101 and ECM1 proteins, combined detections of these two bring a diagnostic output with a high sensitivity and specificity. Similar results were observed for combined detection of TEX101 and SPAG1. The effective using of specific biomarkers from seminal plasma can significantly improve the existing approaches to diagnosis of the causes of male infertility.

Citovat

JEŠETA, Michal, Anna POSPÍŠILOVÁ, Lenka MEKIŇOVÁ, Kateřina FRANZOVÁ, Pavel VENTRUBA, Eva LOUSOVÁ, Bartosz KEMPISTY, Tomáš OŽDIAN, Jana ŽÁKOVÁ a Igor CRHA. Non-Invasive Diagnostics of Male Spermatogenesis from Seminal Plasma: Seminal Proteins. Diagnostics. Basel: MDPI, 2023, roč. 13, č. 15, s. 1-15. ISSN 2075-4418. Dostupné z: https://dx.doi.org/10.3390/diagnostics13152468.

@article{2300444,
   author = {Ješeta, Michal and Pospíšilová, Anna and Mekiňová, Lenka and Franzová, Kateřina and Ventruba, Pavel and Lousová, Eva and Kempisty, Bartosz and Oždian, Tomáš and Žáková, Jana and Crha, Igor},
   article_location = {Basel},
   article_number = {15},
   doi = {http://dx.doi.org/10.3390/diagnostics13152468},
   keywords = {spermatozoa; azoospermia; sperm isolation; sperm analyses},
   language = {eng},
   issn = {2075-4418},
   journal = {Diagnostics},
   title = {Non-Invasive Diagnostics of Male Spermatogenesis from Seminal Plasma: Seminal Proteins},
   url = {https://www.mdpi.com/2075-4418/13/15/2468},
   volume = {13},
   year = {2023}
}

TY  - JOUR
ID  - 2300444
AU  - Ješeta, Michal - Pospíšilová, Anna - Mekiňová, Lenka - Franzová, Kateřina - Ventruba, Pavel - Lousová, Eva - Kempisty, Bartosz - Oždian, Tomáš - Žáková, Jana - Crha, Igor
PY  - 2023
TI  - Non-Invasive Diagnostics of Male Spermatogenesis from Seminal Plasma: Seminal Proteins
JF  - Diagnostics
VL  - 13
IS  - 15
SP  - 1-15
EP  - 1-15
PB  - MDPI
SN  - 20754418
KW  - spermatozoa
KW  - azoospermia
KW  - sperm isolation
KW  - sperm analyses
UR  - https://www.mdpi.com/2075-4418/13/15/2468
N2  - The compounds of seminal plasma have great potential as biomarkers of male fertility and can be used as a diagnostic tool for types of azoospermia. Azoospermia occurs in approximately 1% of the male population, and for an effective therapy of this form of male infertility, it is important to distinguish between obstructive and non-obstructive azoospermia. Proteins in seminal plasma can serve as biomarkers for diagnosing azoospermia. Considering the various types of obstructions, a combination of multiple proteins is advisable for diagnostic purposes. In this context, testicular and epididymal proteins are particularly significant, as they are specific to these tissues and typically absent in ejaculate during most obstructions. A combination of multiple biomarkers is more effective than the analysis of a single protein. This group of markers contains TEX101 and ECM1 proteins, combined detections of these two bring a diagnostic output with a high sensitivity and specificity. Similar results were observed for combined detection of TEX101 and SPAG1. The effective using of specific biomarkers from seminal plasma can significantly improve the existing approaches to diagnosis of the causes of male infertility.
ER  -

JEŠETA, Michal, Anna POSPÍŠILOVÁ, Lenka MEKIŇOVÁ, Kateřina FRANZOVÁ, Pavel VENTRUBA, Eva LOUSOVÁ, Bartosz KEMPISTY, Tomáš OŽDIAN, Jana ŽÁKOVÁ a Igor CRHA. Non-Invasive Diagnostics of Male Spermatogenesis from Seminal Plasma: Seminal Proteins. \textit{Diagnostics}. Basel: MDPI, 2023, roč.~13, č.~15, s.~1-15. ISSN~2075-4418. Dostupné z: https://dx.doi.org/10.3390/diagnostics13152468.

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