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@article{2301606,
author = {Galuška, David and Dlouhá, Lucie and Hubáček, Jaroslav and Kaňková, Kateřina},
article_location = {PRAGUE},
article_number = {5-6},
doi = {http://dx.doi.org/10.14712/fb2022068050159},
keywords = {diabetes mellitus; diabetes complication; polymorphism; Central European population; genetic; GWAS; diabetic neuropathy; diabetic kidney disease; diabetic retinopathy; cardiovascular disease},
language = {eng},
issn = {0015-5500},
journal = {FOLIA BIOLOGICA},
title = {Genetics of T2DM and Its Chronic Complications: Are We Any Closer to the Individual Prediction of Genetic Risk?},
url = {https://fb.littledata.cz/68/5/0159/},
volume = {68},
year = {2022}
}
TY - JOUR
ID - 2301606
AU - Galuška, David - Dlouhá, Lucie - Hubáček, Jaroslav - Kaňková, Kateřina
PY - 2022
TI - Genetics of T2DM and Its Chronic Complications: Are We Any Closer to the Individual Prediction of Genetic Risk?
JF - FOLIA BIOLOGICA
VL - 68
IS - 5-6
SP - 159-179
EP - 159-179
PB - CHARLES UNIV PRAGUE, FIRST FACULTY MEDICINE
SN - 00155500
KW - diabetes mellitus
KW - diabetes complication
KW - polymorphism
KW - Central European population
KW - genetic
KW - GWAS
KW - diabetic neuropathy
KW - diabetic kidney disease
KW - diabetic retinopathy
KW - cardiovascular disease
UR - https://fb.littledata.cz/68/5/0159/
N2 - Type 2 diabetes mellitus (T2DM) is a com-plex disease that has risen in global prevalence over recent decades, resulting in concomitant and enor-mous socio-economic impacts. In addition to the well-documented risk factors of obesity, poor dietary habits and sedentary lifestyles, genetic background plays a key role in the aetiopathogenesis of diabetes and the development of associated micro-and macro -vascular complications. Recent advances in genomic research, notably next-generation sequencing and ge-nome-wide association studies, have greatly improved the efficiency with which genetic backgrounds to com-plex diseases are analysed. To date, several hundred single-nucleotide polymorphisms have been associ-ated with T2DM or its complications. Given the poly -genic background to T2DM (and numerous other complex diseases), the degree of genetic predisposi-tion can be treated as a "continuous trait" quantified by a genetic risk score. Focusing mainly on the Central European population, this review summa-rizes recent state-of-the-art methods that have en-abled us to better determine the genetic architecture of T2DM and the utility of genetic risk scores in dis-ease prediction.
ER -
GALUŠKA, David, Lucie DLOUHÁ, Jaroslav HUBÁČEK a Kateřina KAŇKOVÁ. Genetics of T2DM and Its Chronic Complications: Are We Any Closer to the Individual Prediction of Genetic Risk? \textit{FOLIA BIOLOGICA}. PRAGUE: CHARLES UNIV PRAGUE, FIRST FACULTY MEDICINE, 2022, roč.~68, 5-6, s.~159-179. ISSN~0015-5500. Dostupné z: https://dx.doi.org/10.14712/fb2022068050159.
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