Firefighters and the liver: Exposure to PFAS and PAHs in relation to liver function and serum lipids (CELSPAC-FIREexpo study)

PÁLEŠOVÁ, Nina; Lea MAITRE; Nikos STRATAKIS; Katarína ŘIHÁČKOVÁ; Aleš PINDUR; Jiří KOHOUTEK; Petr ŠENK; Anna BARTOŠKOVÁ; Petr GREGOR; Martine VRIJHEID a Pavel ČUPR. Firefighters and the liver: Exposure to PFAS and PAHs in relation to liver function and serum lipids (CELSPAC-FIREexpo study). International Journal of Hygiene and Environmental Health. Elsevier, 2023, roč. 252, July 2023, s. 1-12. ISSN 1438-4639. Dostupné z: https://doi.org/10.1016/j.ijheh.2023.114215.

Základní údaje

Originální název

Firefighters and the liver: Exposure to PFAS and PAHs in relation to liver function and serum lipids (CELSPAC-FIREexpo study)

Autoři

PÁLEŠOVÁ, Nina; Lea MAITRE; Nikos STRATAKIS; Katarína ŘIHÁČKOVÁ; Aleš PINDUR; Jiří KOHOUTEK; Petr ŠENK; Anna BARTOŠKOVÁ; Petr GREGOR; Martine VRIJHEID a Pavel ČUPR

Vydání

International Journal of Hygiene and Environmental Health, Elsevier, 2023, 1438-4639

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Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10511 Environmental sciences

Stát vydavatele

Německo

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.500

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14310/23:00131701

Organizační jednotka

Přírodovědecká fakulta

DOI

https://doi.org/10.1016/j.ijheh.2023.114215

UT WoS

001041198100001

EID Scopus

2-s2.0-85164450047

Klíčová slova anglicky

Firefighters; Occupational exposure; per-and polyfluoroalkyl substances; PFAS; Polycyclic aromatic hydrocarbons; PAHs; Mixture analysis; Liver function

Štítky

143180, rivok

Příznaky

Recenzováno

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Anotace

V originále

Introduction: Firefighting is one of the most hazardous occupations due to exposure to per-and polyfluoroalkyl substances (PFAS) and polycyclic aromatic hydrocarbons (PAHs). Such exposure is suspected to affect the car-diometabolic profile, e.g., liver function and serum lipids. However, only a few studies have investigated the impact of this specific exposure among firefighters.Methods: Men included in the CELSPAC-FIREexpo study were professional firefighters (n = 52), newly recruited firefighters in training (n = 58), and controls (n = 54). They completed exposure questionnaires and provided 1-3 samples of urine and blood during the 11-week study period to allow assessment of their exposure to PFAS (6 compounds) and PAHs (6 compounds), and to determine biomarkers of liver function (alanine aminotransferase (ALT), gamma-glutamyl transferase (GGT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and total bilirubin (BIL)) and levels of serum lipids (total cholesterol (CHOL), low-density lipoprotein cholesterol (LDL) and triglycerides (TG)). The associations between biomarkers were investigated both cross-sectionally using multiple linear regression (MLR) and Bayesian weighted quantile sum (BWQS) regression and prospec-tively using MLR. The models were adjusted for potential confounders and false discovery rate correction was applied to account for multiplicity.Results: A positive association between exposure to PFAS and PAH mixture and BIL (8 = 28.6%, 95% CrI = 14.6-45.7%) was observed by the BWQS model. When the study population was stratified, in professional firefighters and controls the mixture showed a positive association with CHOL (8 = 29.5%, CrI = 10.3-53.6%) and LDL (8 = 26.7%, CrI = 8.3-48.5%). No statistically significant associations with individual compounds were detected using MLR.Conclusions: This study investigated the associations between exposure to PFAS and PAHs and biomarkers of cardiometabolic health in the Czech men, including firefighters. The results suggest that higher exposure to a mixture of these compounds is associated with an increase in BIL and the alteration of serum lipids, which can result in an unfavourable cardiometabolic profile.

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Návaznosti

EF15_003/0000469, projekt VaV	Název: Cetocoen Plus
EF17_043/0009632, projekt VaV	Název: CETOCOEN Excellence
LX22NPO5104, projekt VaV	Název: Národní institut pro výzkum metabolických a kardiovaskulárních onemocnění (Akronym: CarDia) Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Národní institut pro léčbu metabolických a kardiovaskulárních onemocnění, 5.1 EXCELES
101057014, interní kód MU	Název: Partnership for the Assessment of Risks from Chemicals (Akronym: PARC) Investor: Evropská unie, Partnership for the Assessment of Risks from Chemicals, Klastr 1 - Zdraví
857340, interní kód MU	Název: External and Internal Human Exposure in Urban EXposome (Akronym: Urban_X) Investor: Evropská unie, External and Internal Human Exposure in Urban EXposome, Spreading excellence and widening participation
857487, interní kód MU	Název: R-Exposome Chair: Unlocking the potential of RECETOX in Exposome research (Akronym: R-Exposome Chair) Investor: Evropská unie, R-Exposome Chair: Unlocking the potential of RECETOX in Exposome research, Spreading excellence and widening participation
857560, interní kód MU (Kód CEP: EF17_043/0009632)	Název: CETOCOEN Excellence (Akronym: CETOCOEN Excellence) Investor: Evropská unie, CETOCOEN Excellence, Spreading excellence and widening participation
874627, interní kód MU	Název: EXposome Powered tools for healthy living in urbAN SEttings (Akronym: EXPANSE) Investor: Evropská unie, EXposome Powered tools for healthy living in urbAN SEttings, Health, demographic change and wellbeing (Societal Challenges)
90121, velká výzkumná infrastruktura	Název: RECETOX RI
90233, velká výzkumná infrastruktura	Název: BBMRI.cz IV
90269, velká výzkumná infrastruktura	Název: RECETOX RI II

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