Další formáty:
BibTeX
LaTeX
RIS
@article{2313317,
author = {Erdem, Hakan and Kocoglu, Esra and Ankarali, Handan and ElandSokkary, Rehab and Hakamifard, Atousa and Karaali, Ridvan and Kulzhanova, Sholpan and ElandKholy, Amani and Tehrani, Hamed Azhdari and Khedr, Reham and KayaandKalem, Ayse and Pandak, Nenad and CaglaandSonmezer, Meliha and Nizamuddin, Summiya and BerkandCam, Hande and Guner, Rahmet and Elkholy, Jehan Ali and Llopis, Ferran and Marino, Andrea and Stebel, Roman and Szabo, Balint Gergely and Belitova, Maya and Fadel, Elias and Yetisyigit, Tarkan and Cag, Yasemin and Alkan, Sevil and Kayaaslan, Bircan and Oncu, Serkan and Ozdemir, Mehmet and Yilmaz, Mesut and Isik, Arzu Cennet and Baskol, Dilsah and Sincan, Gulden and Cascio, Antonio and OzerandBalin, Safak and Korkmaz, Nesibe and Ripon, Rezaul Karim and Abbas, Salma and Dumitru, Irina Magdalena and EserandKarlidag, Gulden and Lanzafame, Massimiliano and Rafey, Abdur and Raza, Aun and Sipahi, Oguz Resat and Darazam, Ilad Alavi and Elbahr, Umran and Erdem, Ilknur and Ergen, Pinar and Bilir, Cemil and Caskurlu, Hulya and Erdem, Aysegul and Makek, Mateja Jankovic and Altindis, Mustafa and Lakatos, Botond and Luca, Catalina Mihaela and Yilmaz, Esmeray Mutlu and Nsutebu, Emmanuel and Cakmak, Rumeysa and Sirmatel, Fatma},
article_location = {Amsterdam, Netherlands},
article_number = {3},
doi = {http://dx.doi.org/10.1016/j.ijantimicag.2023.106919},
keywords = {Febrile neutropenia; Bacteraemia; Antimicrobial; Resistance; Antibiotic stewardship},
language = {eng},
issn = {0924-8579},
journal = {International Journal of Antimicrobial Agents},
title = {Prospective analysis of febrile neutropenia patients with bacteraemia: the results of an international ID-IRI study},
url = {https://www.sciencedirect.com/science/article/pii/S092485792300198X},
volume = {62},
year = {2023}
}
TY - JOUR
ID - 2313317
AU - Erdem, Hakan - Kocoglu, Esra - Ankarali, Handan - El-Sokkary, Rehab - Hakamifard, Atousa - Karaali, Ridvan - Kulzhanova, Sholpan - El-Kholy, Amani - Tehrani, Hamed Azhdari - Khedr, Reham - Kaya-Kalem, Ayse - Pandak, Nenad - Cagla-Sonmezer, Meliha - Nizamuddin, Summiya - Berk-Cam, Hande - Guner, Rahmet - Elkholy, Jehan Ali - Llopis, Ferran - Marino, Andrea - Stebel, Roman - Szabo, Balint Gergely - Belitova, Maya - Fadel, Elias - Yetisyigit, Tarkan - Cag, Yasemin - Alkan, Sevil - Kayaaslan, Bircan - Oncu, Serkan - Ozdemir, Mehmet - Yilmaz, Mesut - Isik, Arzu Cennet - Baskol, Dilsah - Sincan, Gulden - Cascio, Antonio - Ozer-Balin, Safak - Korkmaz, Nesibe - Ripon, Rezaul Karim - Abbas, Salma - Dumitru, Irina Magdalena - Eser-Karlidag, Gulden - Lanzafame, Massimiliano - Rafey, Abdur - Raza, Aun - Sipahi, Oguz Resat - Darazam, Ilad Alavi - Elbahr, Umran - Erdem, Ilknur - Ergen, Pinar - Bilir, Cemil - Caskurlu, Hulya - Erdem, Aysegul - Makek, Mateja Jankovic - Altindis, Mustafa - Lakatos, Botond - Luca, Catalina Mihaela - Yilmaz, Esmeray Mutlu - Nsutebu, Emmanuel - Cakmak, Rumeysa - Sirmatel, Fatma
PY - 2023
TI - Prospective analysis of febrile neutropenia patients with bacteraemia: the results of an international ID-IRI study
JF - International Journal of Antimicrobial Agents
VL - 62
IS - 3
SP - 1-10
EP - 1-10
PB - Elsevier Ltd
SN - 09248579
KW - Febrile neutropenia
KW - Bacteraemia
KW - Antimicrobial
KW - Resistance
KW - Antibiotic stewardship
UR - https://www.sciencedirect.com/science/article/pii/S092485792300198X
N2 - Objectives: Bacteraemia during the course of neutropenia is often fatal. We aimed to identify factors predicting mortality to have an insight into better clinical management.Methods: The study has a prospective, observational design using pooled data from febrile neutropenia patients with bacteraemia in 41 centres in 16 countries. Polymicrobial bacteraemias were excluded. It was performed through the Infectious Diseases-International Research Initiative platform between 17 March 2021 and June 2021. Univariate analysis followed by a multivariate binary logistic regression model was used to determine independent predictors of 30-d in-hospital mortality (sensitivity, 81.2%; specificity, 65%). Results: A total of 431 patients were enrolled, and 85 (19.7%) died. Haematological malignancies were detected in 361 (83.7%) patients. Escherichia coli (n = 117, 27.1%), Klebsiellae (n = 95, 22% %), Pseudomonadaceae (n = 63, 14.6%), Coagulase-negative Staphylococci (n = 57, 13.2%), Staphylococcus aureus (n = 30, 7%), and Enterococci (n = 21, 4.9%) were the common pathogens. Meropenem and piperacillin-tazobactam susceptibility, among the isolated pathogens, were only 66.1% and 53.6%, respectively. Pulse rate (odds ratio [OR], 1.018; 95% confidence interval [CI], 1.002-1.034), quick SOFA score (OR, 2.857; 95% CI, 2.120- 3.851), inappropriate antimicrobial treatment (OR, 1.774; 95% CI, 1.011-3.851), Gram-negative bacteraemia (OR, 2.894; 95% CI, 1.437-5.825), bacteraemia of non-urinary origin (OR, 11.262; 95% CI, 1.368-92.720), and advancing age (OR, 1.017; 95% CI, 1.001-1.034) were independent predictors of mortality. Bacteraemia in our neutropenic patient population had distinctive characteristics. The severity of infection and the way to control it with appropriate antimicrobials, and local epidemiological data, came forward. Conclusions: Local antibiotic susceptibility profiles should be integrated into therapeutic recommendations, and infection control and prevention measures should be prioritised in this era of rapidly increasing antibiotic resistance.
ER -
ERDEM, Hakan, Esra KOCOGLU, Handan ANKARALI, Rehab EL-SOKKARY, Atousa HAKAMIFARD, Ridvan KARAALI, Sholpan KULZHANOVA, Amani EL-KHOLY, Hamed Azhdari TEHRANI, Reham KHEDR, Ayse KAYA-KALEM, Nenad PANDAK, Meliha CAGLA-SONMEZER, Summiya NIZAMUDDIN, Hande BERK-CAM, Rahmet GUNER, Jehan Ali ELKHOLY, Ferran LLOPIS, Andrea MARINO, Roman STEBEL, Balint Gergely SZABO, Maya BELITOVA, Elias FADEL, Tarkan YETISYIGIT, Yasemin CAG, Sevil ALKAN, Bircan KAYAASLAN, Serkan ONCU, Mehmet OZDEMIR, Mesut YILMAZ, Arzu Cennet ISIK, Dilsah BASKOL, Gulden SINCAN, Antonio CASCIO, Safak OZER-BALIN, Nesibe KORKMAZ, Rezaul Karim RIPON, Salma ABBAS, Irina Magdalena DUMITRU, Gulden ESER-KARLIDAG, Massimiliano LANZAFAME, Abdur RAFEY, Aun RAZA, Oguz Resat SIPAHI, Ilad Alavi DARAZAM, Umran ELBAHR, Ilknur ERDEM, Pinar ERGEN, Cemil BILIR, Hulya CASKURLU, Aysegul ERDEM, Mateja Jankovic MAKEK, Mustafa ALTINDIS, Botond LAKATOS, Catalina Mihaela LUCA, Esmeray Mutlu YILMAZ, Emmanuel NSUTEBU, Rumeysa CAKMAK a Fatma SIRMATEL. Prospective analysis of febrile neutropenia patients with bacteraemia: the results of an international ID-IRI study. \textit{International Journal of Antimicrobial Agents}. Amsterdam, Netherlands: Elsevier Ltd, 2023, roč.~62, č.~3, s.~1-10. ISSN~0924-8579. Dostupné z: https://dx.doi.org/10.1016/j.ijantimicag.2023.106919.
|
