Další formáty:
BibTeX
LaTeX
RIS
@article{2330760, author = {Obrecht, Denise and Mynarek, Martin and StickanandVerfuerth, Martina and Bison, Brigitte and Schueller, Ulrich and Pajtler, Kristian and Hagel, Christian and Thomale, UlrichandWilhelm and Fleischhack, Gudrun and Timmermann, Beate and Rutkowski, Stefan}, article_location = {Stuttgart}, article_number = {3}, doi = {http://dx.doi.org/10.1055/a-2070-7572}, keywords = {ependymoma; guideline; radiotherapy; chemotherapy; children}, language = {eng}, issn = {0300-8630}, journal = {Klinische Pädiatrie}, title = {Pediatric Intracranial Ependymoma - Recommendations for First-Line Treatment from the German HIT-MED study group}, url = {https://www.thieme-connect.de/products/ejournals/abstract/10.1055/a-2070-7572}, volume = {235}, year = {2023} }
TY - JOUR ID - 2330760 AU - Obrecht, Denise - Mynarek, Martin - Stickan-Verfuerth, Martina - Bison, Brigitte - Schueller, Ulrich - Pajtler, Kristian - Hagel, Christian - Thomale, Ulrich-Wilhelm - Fleischhack, Gudrun - Timmermann, Beate - Rutkowski, Stefan PY - 2023 TI - Pediatric Intracranial Ependymoma - Recommendations for First-Line Treatment from the German HIT-MED study group JF - Klinische Pädiatrie VL - 235 IS - 3 SP - 167-177 EP - 167-177 PB - Georg Thieme Verlag SN - 03008630 KW - ependymoma KW - guideline KW - radiotherapy KW - chemotherapy KW - children UR - https://www.thieme-connect.de/products/ejournals/abstract/10.1055/a-2070-7572 N2 - Biological subtypes of ependymoma (EPN) have been introduced by the recent WHO classification and appear to have great impact on the clinical course, but have not yet found their way into clinical risk stratification. Further, the overall unfavorable prognosis underlines the fact that current therapeutic strategies need further evaluation for improvement. To date, there is no international consensus regarding first-line treatment for children with intracranial EPN. Extent of resection is known to be the most important clinical risk factor, leading to the consensus that consequent evaluation for re-surgery of postoperative residual tumor needs to have highest priority. Furthermore, efficacy of local irradiation is unquestioned and recommended for patients aged > 1 year. In contrast, efficacy of chemotherapy is still under discussion. The European trial SIOP Ependymoma II aims at evaluating efficacy of different chemotherapy elements, leading to the recommendation to include German patients. The BIOMECA study, as biological accompanying study, aims at identifying new prognostic parameters. These results might help to develop targeted therapies for unfavorable biological subtypes. For patient who are not qualified for inclusion into the interventional strata, the HIT-MED Guidance 5.2 provides specific recommendations. This article is meant as an overview of national guidelines regarding diagnostics and treatment as well as of treatment according to the SIOP Ependymoma II trial protocol. ER -
OBRECHT, Denise, Martin MYNAREK, Martina STICKAN-VERFUERTH, Brigitte BISON, Ulrich SCHUELLER, Kristian PAJTLER, Christian HAGEL, Ulrich-Wilhelm THOMALE, Gudrun FLEISCHHACK, Beate TIMMERMANN a Stefan RUTKOWSKI. Pediatric Intracranial Ependymoma - Recommendations for First-Line Treatment from the German HIT-MED study group. \textit{Klinische Pädiatrie}. Stuttgart: Georg Thieme Verlag, 2023, roč.~235, č.~3, s.~167-177. ISSN~0300-8630. Dostupné z: https://dx.doi.org/10.1055/a-2070-7572.
|