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@proceedings{2334207,
author = {Hassan, Ahmed Adel I. H. and Nakano, Yuko and Blaha, Gregor and Hou, YaandMing and Demo, Gabriel},
booktitle = {XIX Discussions in Structural Molecular Biology},
keywords = {translation ribosome cryoEM maturation silencing},
language = {eng},
title = {RimM and RsfS ribosomal factors regulate the translation in bacteria},
url = {https://cssb.structbio.org/xix-discussions-in-structural-molecular-biology-and-6th-user-meeting-of-ciisb-czech-infrastructure-for-integrative-structural-biology/},
year = {2023}
}
TY - CONF
ID - 2334207
AU - Hassan, Ahmed Adel I. H. - Nakano, Yuko - Blaha, Gregor - Hou, Ya-Ming - Demo, Gabriel
PY - 2023
TI - RimM and RsfS ribosomal factors regulate the translation in bacteria
KW - translation ribosome cryoEM maturation silencing
UR - https://cssb.structbio.org/xix-discussions-in-structural-molecular-biology-and-6th-user-meeting-of-ciisb-czech-infrastructure-for-integrative-structural-biology/
N2 - It is crucial for bacteria to save energy when stressed or the access to nutrients is limited. Since synthesis of proteins is an important energy draining source, bacteria rely on slowing down the protein synthesis in harsh conditions. The ribosomal silencing factor (RsfS) has a significant role in stalling the protein synthesis by binding the 50S ribosomal subunit and inhibiting the assembly of 70S ribosome. Meanwhile, the ribosomal maturation factor RimM is vital for the maturation of the 30S small ribosomal subunit. Moreover, during stress RimM is highly enriched in the hibernating 100S dimerized ribosome to stall the protein synthesis and preserve energy. In this work, we use a combination of biochemical studies and cryo-electron microscopy to elucidate the close relationship between RimM and RsfS, and their regulation capabilities on translation.
ER -
HASSAN, Ahmed Adel I. H., Yuko NAKANO, Gregor BLAHA, Ya-Ming HOU a Gabriel DEMO. RimM and RsfS ribosomal factors regulate the translation in bacteria. In \textit{XIX Discussions in Structural Molecular Biology}. 2023.
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