Salicylanilides and Their Anticancer Properties

J 2023

Salicylanilides and Their Anticancer Properties

KAUEROVÁ, Tereza, Maria-Jesus PEREZ-PEREZ a Peter KOLLÁR

Základní údaje

Originální název

Salicylanilides and Their Anticancer Properties

Autoři

KAUEROVÁ, Tereza (203 Česká republika, domácí), Maria-Jesus PEREZ-PEREZ a Peter KOLLÁR (203 Česká republika, garant, domácí)

Vydání

International Journal of Molecular Sciences, Basel, Multidisciplinary Digital Publishing Institute, 2023, 1422-0067

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30104 Pharmacology and pharmacy

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 5.600 v roce 2022

Kód RIV

RIV/00216224:14160/23:00132228

Organizační jednotka

Farmaceutická fakulta

DOI

http://dx.doi.org/10.3390/ijms24021728

UT WoS

000914982800001

Klíčová slova anglicky

salicylanilides; anticancer properties; mitochondrial uncoupling; TK EGFR; STAT3; drug repurposing; niclosamide

Štítky

rivok, ÚFTo

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 5. 4. 2024 07:35, Mgr. Daniela Černá

Anotace

V originále

Salicylanilides are pharmacologically active compounds with a wide spectrum of biological effects. Halogenated salicylanilides, which have been used for decades in human and veterinary medicine as anthelmintics, have recently emerged as candidates for drug repurposing in oncology. The most prominent example of salicylanilide anthelmintic, that is intensively studied for its potential anticancer properties, is niclosamide. Nevertheless, recent studies have discovered extensive anticancer potential in a number of other salicylanilides. This potential of their anticancer action is mediated most likely by diverse mechanisms of action such as uncoupling of oxidative phosphorylation, inhibition of protein tyrosine kinase epidermal growth factor receptor, modulation of different signaling pathways as Wnt/beta-catenin, mTORC1, STAT3, NF-kappa B and Notch signaling pathways or induction of B-Raf V600E inhibition. Here we provide a comprehensive overview of the current knowledge about the proposed mechanisms of action of anticancer activity of salicylanilides based on preclinical in vitro and in vivo studies, or structural requirements for such an activity.

Citovat

KAUEROVÁ, Tereza, Maria-Jesus PEREZ-PEREZ a Peter KOLLÁR. Salicylanilides and Their Anticancer Properties. International Journal of Molecular Sciences. Basel: Multidisciplinary Digital Publishing Institute, 2023, roč. 24, č. 2, s. 1-22. ISSN 1422-0067. Dostupné z: https://dx.doi.org/10.3390/ijms24021728.

@article{2339086,
   author = {Kauerová, Tereza and PerezandPerez, MariaandJesus and Kollár, Peter},
   article_location = {Basel},
   article_number = {2},
   doi = {http://dx.doi.org/10.3390/ijms24021728},
   keywords = {salicylanilides; anticancer properties; mitochondrial uncoupling; TK EGFR; STAT3; drug repurposing; niclosamide},
   language = {eng},
   issn = {1422-0067},
   journal = {International Journal of Molecular Sciences},
   title = {Salicylanilides and Their Anticancer Properties},
   url = {https://www.mdpi.com/1422-0067/24/2/1728},
   volume = {24},
   year = {2023}
}

TY  - JOUR
ID  - 2339086
AU  - Kauerová, Tereza - Perez-Perez, Maria-Jesus - Kollár, Peter
PY  - 2023
TI  - Salicylanilides and Their Anticancer Properties
JF  - International Journal of Molecular Sciences
VL  - 24
IS  - 2
SP  - 1-22
EP  - 1-22
PB  - Multidisciplinary Digital Publishing Institute
SN  - 14220067
KW  - salicylanilides
KW  - anticancer properties
KW  - mitochondrial uncoupling
KW  - TK EGFR
KW  - STAT3
KW  - drug repurposing
KW  - niclosamide
UR  - https://www.mdpi.com/1422-0067/24/2/1728
N2  - Salicylanilides are pharmacologically active compounds with a wide spectrum of biological effects. Halogenated salicylanilides, which have been used for decades in human and veterinary medicine as anthelmintics, have recently emerged as candidates for drug repurposing in oncology. The most prominent example of salicylanilide anthelmintic, that is intensively studied for its potential anticancer properties, is niclosamide. Nevertheless, recent studies have discovered extensive anticancer potential in a number of other salicylanilides. This potential of their anticancer action is mediated most likely by diverse mechanisms of action such as uncoupling of oxidative phosphorylation, inhibition of protein tyrosine kinase epidermal growth factor receptor, modulation of different signaling pathways as Wnt/beta-catenin, mTORC1, STAT3, NF-kappa B and Notch signaling pathways or induction of B-Raf V600E inhibition. Here we provide a comprehensive overview of the current knowledge about the proposed mechanisms of action of anticancer activity of salicylanilides based on preclinical in vitro and in vivo studies, or structural requirements for such an activity.
ER  -

KAUEROVÁ, Tereza, Maria-Jesus PEREZ-PEREZ a Peter KOLLÁR. Salicylanilides and Their Anticancer Properties. \textit{International Journal of Molecular Sciences}. Basel: Multidisciplinary Digital Publishing Institute, 2023, roč.~24, č.~2, s.~1-22. ISSN~1422-0067. Dostupné z: https://dx.doi.org/10.3390/ijms24021728.

Podrobný výpis o publikaci