Treating Epilepsy with Natural Products: Nonsense or
Possibility?

J 2023

Treating Epilepsy with Natural Products: Nonsense or Possibility?

MALANÍK, Milan; Marie ČULENOVÁ; Alice SYCHROVÁ; Adrianna SKIBA; Krystyna SKALICKA-WOZNIAK et. al.

Základní údaje

Originální název

Treating Epilepsy with Natural Products: Nonsense or Possibility?

Autoři

MALANÍK, Milan; Marie ČULENOVÁ; Alice SYCHROVÁ; Adrianna SKIBA; Krystyna SKALICKA-WOZNIAK a Karel ŠMEJKAL

Vydání

PHARMACEUTICALS, BASEL, MDPI, 2023, 1424-8247

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30104 Pharmacology and pharmacy

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.300

Kód RIV

RIV/00216224:14160/23:00132229

Organizační jednotka

Farmaceutická fakulta

DOI

https://doi.org/10.3390/ph16081061

UT WoS

001056447600001

EID Scopus

2-s2.0-85168872774

Klíčová slova anglicky

epilepsy; anticonvulsant; natural products; GABA; AMPA; NMDA

Štítky

rivok, ÚPL

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 14. 11. 2023 10:28, JUDr. Sabina Gajdzioková

Anotace

V originále

Epilepsy is a neurological disease characterized by recurrent seizures that can lead to uncontrollable muscle twitching, changes in sensitivity to sensory perceptions, and disorders of consciousness. Although modern medicine has effective antiepileptic drugs, the need for accessible and cost-effective medication is urgent, and products derived from plants could offer a solution. For this review, we have focused on natural compounds that have shown anticonvulsant activity in in vivo models of epilepsy at relevant doses. In some cases, the effects have been confirmed by clinical data. The results of our search are summarized in tables according to their molecular targets. We have critically evaluated the data we present, identified the most promising therapeutic candidates, and discussed these in the text. Their perspectives are supported by both pharmacokinetic properties and potential interactions. This review is intended to serve as a basis for future research into epilepsy and related disorders.

Citovat

MALANÍK, Milan; Marie ČULENOVÁ; Alice SYCHROVÁ; Adrianna SKIBA; Krystyna SKALICKA-WOZNIAK a Karel ŠMEJKAL. Treating Epilepsy with Natural Products: Nonsense or Possibility? PHARMACEUTICALS. BASEL: MDPI, 2023, roč. 16, č. 8, s. 1-22. ISSN 1424-8247. Dostupné z: https://doi.org/10.3390/ph16081061.

@article{2339097,
   author = {Malaník, Milan and Čulenová, Marie and Sychrová, Alice and Skiba, Adrianna and SkalickaandWozniak, Krystyna and Šmejkal, Karel},
   article_location = {BASEL},
   article_number = {8},
   doi = {https://doi.org/10.3390/ph16081061},
   keywords = {epilepsy; anticonvulsant; natural products; GABA; AMPA; NMDA},
   language = {eng},
   issn = {1424-8247},
   journal = {PHARMACEUTICALS},
   title = {Treating Epilepsy with Natural Products: Nonsense or Possibility?},
   url = {https://www.mdpi.com/1424-8247/16/8/1061},
   volume = {16},
   year = {2023}
}

TY  - JOUR
ID  - 2339097
AU  - Malaník, Milan - Čulenová, Marie - Sychrová, Alice - Skiba, Adrianna - Skalicka-Wozniak, Krystyna - Šmejkal, Karel
PY  - 2023
TI  - Treating Epilepsy with Natural Products: Nonsense or Possibility?
JF  - PHARMACEUTICALS
VL  - 16
IS  - 8
SP  - 1-22
EP  - 1-22
PB  - MDPI
SN  - 14248247
KW  - epilepsy
KW  - anticonvulsant
KW  - natural products
KW  - GABA
KW  - AMPA
KW  - NMDA
UR  - https://www.mdpi.com/1424-8247/16/8/1061
N2  - Epilepsy is a neurological disease characterized by recurrent seizures that can lead to uncontrollable muscle twitching, changes in sensitivity to sensory perceptions, and disorders of consciousness. Although modern medicine has effective antiepileptic drugs, the need for accessible and cost-effective medication is urgent, and products derived from plants could offer a solution. For this review, we have focused on natural compounds that have shown anticonvulsant activity in in vivo models of epilepsy at relevant doses. In some cases, the effects have been confirmed by clinical data. The results of our search are summarized in tables according to their molecular targets. We have critically evaluated the data we present, identified the most promising therapeutic candidates, and discussed these in the text. Their perspectives are supported by both pharmacokinetic properties and potential interactions. This review is intended to serve as a basis for future research into epilepsy and related disorders.
ER  -

MALANÍK, Milan; Marie ČULENOVÁ; Alice SYCHROVÁ; Adrianna SKIBA; Krystyna SKALICKA-WOZNIAK a Karel ŠMEJKAL. Treating Epilepsy with Natural Products: Nonsense or Possibility? \textit{PHARMACEUTICALS}. BASEL: MDPI, 2023, roč.~16, č.~8, s.~1-22. ISSN~1424-8247. Dostupné z: https://doi.org/10.3390/ph16081061.

Přehled o publikaci