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@article{2339478,
author = {Staníková, Andrea and Jouza, Martin and Bohošová, Júlia and Slabý, Ondřej and Jabandžiev, Petr},
article_location = {LONDON},
article_number = {1},
doi = {http://dx.doi.org/10.1136/bmjpo-2023-002172},
keywords = {microbiome; necrotising enterocolitis; preterm neonates},
language = {eng},
issn = {2399-9772},
journal = {BMJ Paediatrics Open},
title = {Role of the microbiome in pathophysiology of necrotising enterocolitis in preterm neonates},
url = {https://bmjpaedsopen.bmj.com/content/7/1/e002172},
volume = {7},
year = {2023}
}
TY - JOUR
ID - 2339478
AU - Staníková, Andrea - Jouza, Martin - Bohošová, Júlia - Slabý, Ondřej - Jabandžiev, Petr
PY - 2023
TI - Role of the microbiome in pathophysiology of necrotising enterocolitis in preterm neonates
JF - BMJ Paediatrics Open
VL - 7
IS - 1
SP - 1-8
EP - 1-8
PB - BMJ PUBLISHING GROUP
SN - 23999772
KW - microbiome
KW - necrotising enterocolitis
KW - preterm neonates
UR - https://bmjpaedsopen.bmj.com/content/7/1/e002172
N2 - Although necrotising enterocolitis (NEC) is a serious, life-threatening disease, improved neonatal care is increasing the number of survivors with NEC among extremely preterm neonates. Therapy is nevertheless mostly symptomatic and the mortality rate remains high, especially among neonates requiring surgery. Therefore, it is important to focus on preventing the disease and modifiable risk factors. NEC’s pathophysiology is multifaceted, with key factors being immaturity of the immune and barrier protective mechanisms of the premature gut and exaggerated proinflammatory reaction to insults like gut hypoxia, enteral nutrition or microbial dysbiosis. The role of the intestinal microbiome in the pathophysiology of NEC has been a subject of research for many years, but to date no specific pathogen or type of dysbiosis has been connected with NEC development. This review assesses current knowledge as to the role of the intestinal microbiota in the pathophysiology of NEC and the possibilities for positively influencing it.
ER -
STANÍKOVÁ, Andrea, Martin JOUZA, Júlia BOHOŠOVÁ, Ondřej SLABÝ a Petr JABANDŽIEV. Role of the microbiome in pathophysiology of necrotising enterocolitis in preterm neonates. \textit{BMJ Paediatrics Open}. LONDON: BMJ PUBLISHING GROUP, 2023, roč.~7, č.~1, s.~1-8. ISSN~2399-9772. Dostupné z: https://dx.doi.org/10.1136/bmjpo-2023-002172.
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