| PENJARLA, Srishylam, Paidi Yella REDDY, Santhosh PENTA, Yogesh S SANGHVI, Luděk EYER, Michal ŠTEFÁNIK, Zuzana KRÁTKA, Daniel RŮŽEK a Shyamapada BANERJEE. Synthesis and Antiviral Activity of 2′-Modified L-Nucleoside Analogues. ChemistrySelect. Wiley, 2023, roč. 8, č. 48, s. 1-11. ISSN 2365-6549. Dostupné z: https://dx.doi.org/10.1002/slct.202303585. |
Další formáty:
BibTeX
LaTeX
RIS
@article{2353818,
author = {Penjarla, Srishylam and Reddy, Paidi Yella and Penta, Santhosh and Sanghvi, Yogesh S and Eyer, Luděk and Štefánik, Michal and Krátka, Zuzana and Růžek, Daniel and Banerjee, Shyamapada},
article_number = {48},
doi = {http://dx.doi.org/10.1002/slct.202303585},
keywords = {Antiviral Agent; L-2 2'-anhydrouridine; L-Arabinose; Cytotoxicity; L-Nucleoside},
language = {eng},
issn = {2365-6549},
journal = {ChemistrySelect},
title = {Synthesis and Antiviral Activity of 2′-Modified L-Nucleoside Analogues.},
url = {https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/slct.202303585},
volume = {8},
year = {2023}
}
TY - JOUR
ID - 2353818
AU - Penjarla, Srishylam - Reddy, Paidi Yella - Penta, Santhosh - Sanghvi, Yogesh S - Eyer, Luděk - Štefánik, Michal - Krátka, Zuzana - Růžek, Daniel - Banerjee, Shyamapada
PY - 2023
TI - Synthesis and Antiviral Activity of 2′-Modified L-Nucleoside Analogues.
JF - ChemistrySelect
VL - 8
IS - 48
SP - 1-11
EP - 1-11
PB - Wiley
SN - 23656549
KW - Antiviral Agent
KW - L-2 2'-anhydrouridine
KW - L-Arabinose
KW - Cytotoxicity
KW - L-Nucleoside
UR - https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/slct.202303585
N2 - Nucleoside analogues have been the foundation of antiviral therapy over the past few decades. D-nucleosides with natural stereochemistry occupies the lion share of the marketed antiviral agents. However, much less effort have been put towards the development of L-nucleosides as antiviral agents. Herein, our effort towards the synthesis of 2′ -substituted L-nucleoside analogues is reported as an emerging class of antiviral agents. Biological activity of the synthesized L-nucleosided was evaluated against two viruses of importance, tick-borne encephalitis virus (TBEV) and Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) in adenocarcinomic human alveolar basal epithelial cells (A459) and Vero cells. Ring opening of L-2, 2′-Anhydrouridine (2) with various nucleophiles to make several 2‘-substituted L-nucleosides is the key synthetic outcome. This development has paved the way in the synthesis of many new analogues of 2‘-substituted L-nucleosides for numerous applications.
ER -
PENJARLA, Srishylam, Paidi Yella REDDY, Santhosh PENTA, Yogesh S SANGHVI, Luděk EYER, Michal ŠTEFÁNIK, Zuzana KRÁTKA, Daniel RŮŽEK a Shyamapada BANERJEE. Synthesis and Antiviral Activity of 2′-Modified L-Nucleoside Analogues. \textit{ChemistrySelect}. Wiley, 2023, roč.~8, č.~48, s.~1-11. ISSN~2365-6549. Dostupné z: https://dx.doi.org/10.1002/slct.202303585.
|
