Association between polymorphism rs2421943 of the
insulin-degrading enzyme and schizophrenia: Preliminary report

J 2023

Association between polymorphism rs2421943 of the insulin-degrading enzyme and schizophrenia: Preliminary report

AMBROZOVÁ, Laura; Tomáš ZEMAN; Vladimír JANOUT; Jana JANOUTOVÁ; Jan LOCHMAN et al.

Základní údaje

Originální název

Association between polymorphism rs2421943 of the insulin-degrading enzyme and schizophrenia: Preliminary report

Autoři

AMBROZOVÁ, Laura; Tomáš ZEMAN; Vladimír JANOUT; Jana JANOUTOVÁ; Jan LOCHMAN a Omar ŠERÝ

Vydání

Journal of Clinical Laboratory Analysis, Wiley, 2023, 0887-8013

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30210 Clinical neurology

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.600

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14310/23:00134349

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova anglicky

candidate gene analyses; genetic association study; insulin-degrading enzyme (IDE); miRNA; schizophrenic disorder; single nucleotide polymorphism (SNP)

Štítky

14313050, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 3. 1. 2024 11:28, Mgr. Marie Novosadová Šípková, DiS.

Anotace

V originále

Background Insulin-degrading enzyme (IDE) is an important gene in studies of the pathophysiology of type 2 diabetes mellitus (T2DM). Recent studies have suggested a possible link between type 2 diabetes mellitus (T2DM) and the pathophysiology of schizophrenia (SZ). At the same time, significant changes in insulin-degrading enzyme (IDE) gene expression have been found in the brains of people with schizophrenia. These findings highlight the need to further investigate the role of IDE in schizophrenia pathogenesis. Methods We enrolled 733 participants from the Czech Republic, including 383 patients with schizophrenia and 350 healthy controls. Our study focused on the single nucleotide polymorphism (SNP) rs2421943 in the IDE gene, which has previously been associated with the pathogenesis of Alzheimer's disease. The SNP was analyzed using the PCR-RFLP method. Results The G allele of the rs2421943 polymorphism was found to significantly increase the risk of developing SZ (p < 0.01) when a gender-based analysis showed that both AG and GG genotypes were associated with a more than 1.55 times increased risk of SZ in females (p < 0.03) but not in males. Besides, we identified a potential binding site at the G allele locus for has-miR-7110-5p, providing a potential mechanism for the observed association. Conclusion Our results confirm the role of the IDE gene in schizophrenia pathogenesis and suggest that future research should investigate the relationship between miRNA and estrogen influence on IDE expression in schizophrenia pathogenesis.

Návaznosti

GP309/09/P361, projekt VaV

Název: Vztah interakce polymorfismů kandidátních genů k patogenezi schizofrenie

Investor: Grantová agentura ČR, Vztah interakce polymorfismů kandidátních genů k patogenezi schizofrenie

Citovat

AMBROZOVÁ, Laura; Tomáš ZEMAN; Vladimír JANOUT; Jana JANOUTOVÁ; Jan LOCHMAN a Omar ŠERÝ. Association between polymorphism rs2421943 of the insulin-degrading enzyme and schizophrenia: Preliminary report. Journal of Clinical Laboratory Analysis. Wiley, 2023, roč. 37, 13-14, s. 1-7. ISSN 0887-8013. Dostupné z: https://doi.org/10.1002/jcla.24949.

@article{2355377,
   author = {Ambrozová, Laura and Zeman, Tomáš and Janout, Vladimír and Janoutová, Jana and Lochman, Jan and Šerý, Omar},
   article_number = {13-14},
   doi = {https://doi.org/10.1002/jcla.24949},
   keywords = {candidate gene analyses; genetic association study; insulin-degrading enzyme (IDE); miRNA; schizophrenic disorder; single nucleotide polymorphism (SNP)},
   language = {eng},
   issn = {0887-8013},
   journal = {Journal of Clinical Laboratory Analysis},
   title = {Association between polymorphism rs2421943 of the insulin-degrading enzyme and schizophrenia: Preliminary report},
   url = {https://doi.org/10.1002/jcla.24949},
   volume = {37},
   year = {2023}
}

TY  - JOUR
ID  - 2355377
AU  - Ambrozová, Laura - Zeman, Tomáš - Janout, Vladimír - Janoutová, Jana - Lochman, Jan - Šerý, Omar
PY  - 2023
TI  - Association between polymorphism rs2421943 of the insulin-degrading enzyme and schizophrenia: Preliminary report
JF  - Journal of Clinical Laboratory Analysis
VL  - 37
IS  - 13-14
SP  - 1-7
EP  - 1-7
PB  - Wiley
SN  - 08878013
KW  - candidate gene analyses
KW  - genetic association study
KW  - insulin-degrading enzyme (IDE)
KW  - miRNA
KW  - schizophrenic disorder
KW  - single nucleotide polymorphism (SNP)
UR  - https://doi.org/10.1002/jcla.24949
N2  - Background Insulin-degrading enzyme (IDE) is an important gene in studies of the pathophysiology of type 2 diabetes mellitus (T2DM). Recent studies have suggested a possible link between type 2 diabetes mellitus (T2DM) and the pathophysiology of schizophrenia (SZ). At the same time, significant changes in insulin-degrading enzyme (IDE) gene expression have been found in the brains of people with schizophrenia. These findings highlight the need to further investigate the role of IDE in schizophrenia pathogenesis. Methods We enrolled 733 participants from the Czech Republic, including 383 patients with schizophrenia and 350 healthy controls. Our study focused on the single nucleotide polymorphism (SNP) rs2421943 in the IDE gene, which has previously been associated with the pathogenesis of Alzheimer's disease. The SNP was analyzed using the PCR-RFLP method. Results The G allele of the rs2421943 polymorphism was found to significantly increase the risk of developing SZ (p < 0.01) when a gender-based analysis showed that both AG and GG genotypes were associated with a more than 1.55 times increased risk of SZ in females (p < 0.03) but not in males. Besides, we identified a potential binding site at the G allele locus for has-miR-7110-5p, providing a potential mechanism for the observed association. Conclusion Our results confirm the role of the IDE gene in schizophrenia pathogenesis and suggest that future research should investigate the relationship between miRNA and estrogen influence on IDE expression in schizophrenia pathogenesis.
ER  -

AMBROZOVÁ, Laura; Tomáš ZEMAN; Vladimír JANOUT; Jana JANOUTOVÁ; Jan LOCHMAN a Omar ŠERÝ. Association between polymorphism rs2421943 of the insulin-degrading enzyme and schizophrenia: Preliminary report. \textit{Journal of Clinical Laboratory Analysis}. Wiley, 2023, roč.~37, 13-14, s.~1-7. ISSN~0887-8013. Dostupné z: https://doi.org/10.1002/jcla.24949.

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