Perinatal maternal mental health and amygdala morphology in
young adulthood

J 2023

Perinatal maternal mental health and amygdala morphology in young adulthood

GUMA, Elisa; Lenka ANDRÝSKOVÁ; Milan BRÁZDIL; M. Mallar CHAKRAVARTY; Klára MAREČKOVÁ et al.

Základní údaje

Originální název

Perinatal maternal mental health and amygdala morphology in young adulthood

Autoři

GUMA, Elisa; Lenka ANDRÝSKOVÁ ; Milan BRÁZDIL; M. Mallar CHAKRAVARTY a Klára MAREČKOVÁ

Vydání

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Elsevier, 2023, 0278-5846

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30210 Clinical neurology

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 5.300

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14740/23:00132760

Organizační jednotka

Středoevropský technologický institut

Klíčová slova anglicky

Maternal anxiety; Perinatal depression; Amygdala; Volume; Surface area

Štítky

143180, CF MAFIL, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 17. 6. 2025 09:32, Mgr. Michaela Hylsová, Ph.D.

Anotace

V originále

The pre- and perinatal environment is thought to play a critical role in shaping brain development. Specifically, maternal mental health and maternal care have been shown to influence offspring brain development in regions implicated in emotional regulation such as the amygdala. In this study, we used data from a neuroimaging follow-up of a prenatal birth-cohort, the European Longitudinal Study of Pregnancy and Childhood, to investigate the impact of early postnatal maternal anxiety/co-dependence, and prenatal and early-postnatal depression and dysregulated mood on amygdala volume and morphology in young adulthood (n = 103). We observed that in typically developing young adults, greater maternal anxiety/co-dependence after birth was significantly associated with lower volume (right: t = −2.913, p = 0.0045, β = −0.523; left: t = −1.471, p = 0.144, β = −0.248) and non-significantly associated with surface area (right: t = −3.502, q = 0.069, <10%FDR, β = −0.090, left: t = −3.137, q = 0.117, <10%FDR, = −0.088) of the amygdala in young adulthood. Conversely, prenatal maternal depression and mood dysregulation in the early postnatal period was not associated with any volumetric or morphological changes in the amygdala in young adulthood. Our findings provide evidence for subtle but long-lasting alterations to amygdala morphology associated with differences in maternal anxiety/co-dependence in early development.

Návaznosti

NU20J-04-00022, projekt VaV

Název: Zdravé stárnutí mozku: Celoživotní perspektiva

Investor: Ministerstvo zdravotnictví ČR, Zdravé stárnutí mozku: Celoživotní perspektiva, Podprogram 2 - juniorský - výzkumníci do 35 let

90051, velká výzkumná infrastruktura

Název: RECETOX II

90062, velká výzkumná infrastruktura

Název: Czech-BioImaging

90129, velká výzkumná infrastruktura

Název: Czech-BioImaging II

Citovat

GUMA, Elisa; Lenka ANDRÝSKOVÁ; Milan BRÁZDIL; M. Mallar CHAKRAVARTY a Klára MAREČKOVÁ. Perinatal maternal mental health and amygdala morphology in young adulthood. Progress in Neuro-Psychopharmacology and Biological Psychiatry. Elsevier, 2023, roč. 122, March, s. 1-8. ISSN 0278-5846. Dostupné z: https://doi.org/10.1016/j.pnpbp.2022.110676.

@article{2355878,
   author = {Guma, Elisa and Andrýsková, Lenka and Brázdil, Milan and Chakravarty, M. Mallar and Marečková, Klára},
   article_number = {March},
   doi = {https://doi.org/10.1016/j.pnpbp.2022.110676},
   keywords = {Maternal anxiety; Perinatal depression; Amygdala; Volume; Surface area},
   language = {eng},
   issn = {0278-5846},
   journal = {Progress in Neuro-Psychopharmacology and Biological Psychiatry},
   title = {Perinatal maternal mental health and amygdala morphology in young adulthood},
   url = {https://doi.org/10.1016/j.pnpbp.2022.110676},
   volume = {122},
   year = {2023}
}

TY  - JOUR
ID  - 2355878
AU  - Guma, Elisa - Andrýsková, Lenka - Brázdil, Milan - Chakravarty, M. Mallar - Marečková, Klára
PY  - 2023
TI  - Perinatal maternal mental health and amygdala morphology in young adulthood
JF  - Progress in Neuro-Psychopharmacology and Biological Psychiatry
VL  - 122
IS  - March
SP  - 1-8
EP  - 1-8
PB  - Elsevier
SN  - 02785846
KW  - Maternal anxiety
KW  - Perinatal depression
KW  - Amygdala
KW  - Volume
KW  - Surface area
UR  - https://doi.org/10.1016/j.pnpbp.2022.110676
N2  - The pre- and perinatal environment is thought to play a critical role in shaping brain development. Specifically, maternal mental health and maternal care have been shown to influence offspring brain development in regions implicated in emotional regulation such as the amygdala. In this study, we used data from a neuroimaging follow-up of a prenatal birth-cohort, the European Longitudinal Study of Pregnancy and Childhood, to investigate the impact of early postnatal maternal anxiety/co-dependence, and prenatal and early-postnatal depression and dysregulated mood on amygdala volume and morphology in young adulthood (n = 103). We observed that in typically developing young adults, greater maternal anxiety/co-dependence after birth was significantly associated with lower volume (right: t = −2.913, p = 0.0045, β = −0.523; left: t = −1.471, p = 0.144, β = −0.248) and non-significantly associated with surface area (right: t = −3.502, q = 0.069, <10%FDR, β = −0.090, left: t = −3.137, q = 0.117, <10%FDR, = −0.088) of the amygdala in young adulthood. Conversely, prenatal maternal depression and mood dysregulation in the early postnatal period was not associated with any volumetric or morphological changes in the amygdala in young adulthood. Our findings provide evidence for subtle but long-lasting alterations to amygdala morphology associated with differences in maternal anxiety/co-dependence in early development.
ER  -

GUMA, Elisa; Lenka ANDRÝSKOVÁ; Milan BRÁZDIL; M. Mallar CHAKRAVARTY a Klára MAREČKOVÁ. Perinatal maternal mental health and amygdala morphology in young adulthood. \textit{Progress in Neuro-Psychopharmacology and Biological Psychiatry}. Elsevier, 2023, roč.~122, March, s.~1-8. ISSN~0278-5846. Dostupné z: https://doi.org/10.1016/j.pnpbp.2022.110676.

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