Organotin(IV)-Decorated Graphene Quantum Dots as Dual Platform
for Molecular Imaging and Treatment of Triple Negative Breast
Cancer

J 2023

Organotin(IV)-Decorated Graphene Quantum Dots as Dual Platform for Molecular Imaging and Treatment of Triple Negative Breast Cancer

GOMEZ PEREZ, Inmaculada Jennifer; Karina OVEJERO-PAREDES; Jose Manuel MENDEZ-ARRIAGA; Nadezda PIZUROVA; Marco FILICE et. al.

Základní údaje

Originální název

Organotin(IV)-Decorated Graphene Quantum Dots as Dual Platform for Molecular Imaging and Treatment of Triple Negative Breast Cancer

Autoři

GOMEZ PEREZ, Inmaculada Jennifer; Karina OVEJERO-PAREDES; Jose Manuel MENDEZ-ARRIAGA; Nadezda PIZUROVA; Marco FILICE; Lenka ZAJÍČKOVÁ; Sanjiv PRASHAR a Santiago GOMEZ-RUIZ

Vydání

Chemistry—A European Journal, Wiley, 2023, 0947-6539

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10302 Condensed matter physics

Stát vydavatele

Německo

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.900

Kód RIV

RIV/00216224:14310/23:00133047

Organizační jednotka

Přírodovědecká fakulta

DOI

https://doi.org/10.1002/chem.202301845

UT WoS

001067847400001

EID Scopus

2-s2.0-85171331656

Klíčová slova anglicky

biomedical molecular imaging; graphene quantum dots; metallodrugs; organotin; theranostic

Štítky

14312020, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 16. 1. 2024 14:41, Mgr. Marie Novosadová Šípková, DiS.

Anotace

V originále

The pharmacological activity of organotin(IV) complexes in cancer therapy is well recognized but their large applicability is hampered by their poor water solubility. Hence, carbon dots, in particular nitrogen-doped graphene quantum dots (NGQDs), may be a promising alternative for the efficient delivery of organotin(IV) compounds as they have a substantial aqueous solubility, a good chemical stability, and non-toxicity as well as a bright photoluminescence that make them ideal for theranostic applications against cancer. Two different multifunctional nanosystems have been synthesized and fully characterized based on two fragments of organotin-based cytotoxic compounds and 4-formylbenzoic acid (FBA), covalently grafted onto the NGQDs surface. Subsequently, an in vitro determination of the therapeutic and theranostic potential of the achieved multifunctional systems was carried out. The results showed a high cytotoxic potential of the NGQDs-FBA-Sn materials against breast cancer cell line (MDA-MB-231) and a lower effect on a non-cancer cell line (kidney cells, HEK293T). Besides, thanks to their optical properties, the dots enabled their fluorescence molecular imaging in the cytoplasmatic region of the cells pointing towards a successful cellular uptake and a release of the metallodrug inside cancer cells (NGQDs-FBA-Sn).

Návaznosti

EF20_079/0017045, projekt VaV

Název: MSCAfellow4@MUNI

LM2018121, projekt VaV

Název: Výzkumná infrastruktura RECETOX (Akronym: RECETOX RI)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, RECETOX RI

90110, velká výzkumná infrastruktura

Název: CzechNanoLab

Citovat

GOMEZ PEREZ, Inmaculada Jennifer; Karina OVEJERO-PAREDES; Jose Manuel MENDEZ-ARRIAGA; Nadezda PIZUROVA; Marco FILICE; Lenka ZAJÍČKOVÁ; Sanjiv PRASHAR a Santiago GOMEZ-RUIZ. Organotin(IV)-Decorated Graphene Quantum Dots as Dual Platform for Molecular Imaging and Treatment of Triple Negative Breast Cancer. Chemistry—A European Journal. Wiley, 2023, roč. 29, č. 60, s. 1-8. ISSN 0947-6539. Dostupné z: https://doi.org/10.1002/chem.202301845.

@article{2361657,
   author = {Gomez Perez, Inmaculada Jennifer and OvejeroandParedes, Karina and MendezandArriaga, Jose Manuel and Pizurova, Nadezda and Filice, Marco and Zajíčková, Lenka and Prashar, Sanjiv and GomezandRuiz, Santiago},
   article_number = {60},
   doi = {https://doi.org/10.1002/chem.202301845},
   keywords = {biomedical molecular imaging; graphene quantum dots; metallodrugs; organotin; theranostic},
   language = {eng},
   issn = {0947-6539},
   journal = {Chemistry—A European Journal},
   title = {Organotin(IV)-Decorated Graphene Quantum Dots as Dual Platform for Molecular Imaging and Treatment of Triple Negative Breast Cancer},
   url = {https://doi.org/10.1002/chem.202301845},
   volume = {29},
   year = {2023}
}

TY  - JOUR
ID  - 2361657
AU  - Gomez Perez, Inmaculada Jennifer - Ovejero-Paredes, Karina - Mendez-Arriaga, Jose Manuel - Pizurova, Nadezda - Filice, Marco - Zajíčková, Lenka - Prashar, Sanjiv - Gomez-Ruiz, Santiago
PY  - 2023
TI  - Organotin(IV)-Decorated Graphene Quantum Dots as Dual Platform for Molecular Imaging and Treatment of Triple Negative Breast Cancer
JF  - Chemistry—A European Journal
VL  - 29
IS  - 60
SP  - 1-8
EP  - 1-8
PB  - Wiley
SN  - 09476539
KW  - biomedical molecular imaging
KW  - graphene quantum dots
KW  - metallodrugs
KW  - organotin
KW  - theranostic
UR  - https://doi.org/10.1002/chem.202301845
N2  - The pharmacological activity of organotin(IV) complexes in cancer therapy is well recognized but their large applicability is hampered by their poor water solubility. Hence, carbon dots, in particular nitrogen-doped graphene quantum dots (NGQDs), may be a promising alternative for the efficient delivery of organotin(IV) compounds as they have a substantial aqueous solubility, a good chemical stability, and non-toxicity as well as a bright photoluminescence that make them ideal for theranostic applications against cancer. Two different multifunctional nanosystems have been synthesized and fully characterized based on two fragments of organotin-based cytotoxic compounds and 4-formylbenzoic acid (FBA), covalently grafted onto the NGQDs surface. Subsequently, an in vitro determination of the therapeutic and theranostic potential of the achieved multifunctional systems was carried out. The results showed a high cytotoxic potential of the NGQDs-FBA-Sn materials against breast cancer cell line (MDA-MB-231) and a lower effect on a non-cancer cell line (kidney cells, HEK293T). Besides, thanks to their optical properties, the dots enabled their fluorescence molecular imaging in the cytoplasmatic region of the cells pointing towards a successful cellular uptake and a release of the metallodrug inside cancer cells (NGQDs-FBA-Sn).
ER  -

GOMEZ PEREZ, Inmaculada Jennifer; Karina OVEJERO-PAREDES; Jose Manuel MENDEZ-ARRIAGA; Nadezda PIZUROVA; Marco FILICE; Lenka ZAJÍČKOVÁ; Sanjiv PRASHAR a Santiago GOMEZ-RUIZ. Organotin(IV)-Decorated Graphene Quantum Dots as Dual Platform for Molecular Imaging and Treatment of Triple Negative Breast Cancer. \textit{Chemistry—A European Journal}. Wiley, 2023, roč.~29, č.~60, s.~1-8. ISSN~0947-6539. Dostupné z: https://doi.org/10.1002/chem.202301845.

Přehled o publikaci