A Critical Review on the Opportunity to Use Placenta and
Innovative Biomonitoring Methods to Characterize the Prenatal
Chemical Exposome

J 2023

A Critical Review on the Opportunity to Use Placenta and Innovative Biomonitoring Methods to Characterize the Prenatal Chemical Exposome

CONTINI, Thomas Angelo Adrien, Remi BERANGER, Luc MULTIGNER, Jana KLÁNOVÁ, Elliott James PRICE et. al.

Základní údaje

Originální název

A Critical Review on the Opportunity to Use Placenta and Innovative Biomonitoring Methods to Characterize the Prenatal Chemical Exposome

Autoři

CONTINI, Thomas Angelo Adrien (250 Francie, domácí), Remi BERANGER, Luc MULTIGNER, Jana KLÁNOVÁ (203 Česká republika, garant, domácí), Elliott James PRICE (826 Velká Británie a Severní Irsko, domácí) a Arthur DAVID

Vydání

ENVIRONMENTAL SCIENCE & TECHNOLOGY, WASHINGTON, AMER CHEMICAL SOC, 2023, 0013-936X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10511 Environmental sciences

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 11.400 v roce 2022

Kód RIV

RIV/00216224:14310/23:00133183

Organizační jednotka

Přírodovědecká fakulta

DOI

http://dx.doi.org/10.1021/acs.est.3c04845

UT WoS

001080892700001

Klíčová slova anglicky

placenta; prenatal; xenobiotics; high-resolutionmass spectrometry; chemical exposomics; metabolomics; suspect screening; nontargeted

Štítky

rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 23. 1. 2024 20:49, Mgr. Michaela Hylsová, Ph.D.

Anotace

V originále

Adverse effects associated with chemical exposures during pregnancy include several developmental and reproductive disorders. However, considering the tens of thousands of chemicals present on the market, the effects of chemical mixtures on the developing fetus is still likely underestimated. In this critical review, we discuss the potential to apply innovative biomonitoring methods using high-resolution mass spectrometry (HRMS) on placenta to improve the monitoring of chemical exposure during pregnancy. The physiology of the placenta and its relevance as a matrix for monitoring chemical exposures and their effects on fetal health is first outlined. We then identify several key parameters that require further investigations before placenta can be used for large-scale monitoring in a robust manner. Most critical is the need for standardization of placental sampling. Placenta is a highly heterogeneous organ, and knowledge of the intraplacenta variability of chemical composition is required to ensure unbiased and robust interindividual comparisons. Other important variables include the time of collection, the sex of the fetus, and mode of delivery. Finally, we discuss the first applications of HRMS methods on the placenta to decipher the chemical exposome and describe how the use of placenta can complement biofluids collected on the mother or the fetus.

Návaznosti

EF17_043/0009632, projekt VaV

Název: CETOCOEN Excellence

LM2023069, projekt VaV

Název: Výzkumná infrastruktura RECETOX

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Výzkumná infrastruktura RECETOX

857560, interní kód MU
(Kód CEP: EF17_043/0009632)

Název: CETOCOEN Excellence (Akronym: CETOCOEN Excellence)

Investor: Evropská unie, CETOCOEN Excellence, Spreading excellence and widening participation

Citovat

CONTINI, Thomas Angelo Adrien, Remi BERANGER, Luc MULTIGNER, Jana KLÁNOVÁ, Elliott James PRICE a Arthur DAVID. A Critical Review on the Opportunity to Use Placenta and Innovative Biomonitoring Methods to Characterize the Prenatal Chemical Exposome. ENVIRONMENTAL SCIENCE & TECHNOLOGY. WASHINGTON: AMER CHEMICAL SOC, 2023, roč. 57, č. 41, s. 15301-15313. ISSN 0013-936X. Dostupné z: https://dx.doi.org/10.1021/acs.est.3c04845.

@article{2364939,
   author = {Contini, Thomas Angelo Adrien and Beranger, Remi and Multigner, Luc and Klánová, Jana and Price, Elliott James and David, Arthur},
   article_location = {WASHINGTON},
   article_number = {41},
   doi = {http://dx.doi.org/10.1021/acs.est.3c04845},
   keywords = {placenta; prenatal; xenobiotics; high-resolutionmass spectrometry; chemical exposomics; metabolomics; suspect screening; nontargeted},
   language = {eng},
   issn = {0013-936X},
   journal = {ENVIRONMENTAL SCIENCE & TECHNOLOGY},
   title = {A Critical Review on the Opportunity to Use Placenta and Innovative Biomonitoring Methods to Characterize the Prenatal Chemical Exposome},
   url = {https://pubs.acs.org/doi/10.1021/acs.est.3c04845},
   volume = {57},
   year = {2023}
}

TY  - JOUR
ID  - 2364939
AU  - Contini, Thomas Angelo Adrien - Beranger, Remi - Multigner, Luc - Klánová, Jana - Price, Elliott James - David, Arthur
PY  - 2023
TI  - A Critical Review on the Opportunity to Use Placenta and Innovative Biomonitoring Methods to Characterize the Prenatal Chemical Exposome
JF  - ENVIRONMENTAL SCIENCE & TECHNOLOGY
VL  - 57
IS  - 41
SP  - 15301-15313
EP  - 15301-15313
PB  - AMER CHEMICAL SOC
SN  - 0013936X
KW  - placenta
KW  - prenatal
KW  - xenobiotics
KW  - high-resolutionmass spectrometry
KW  - chemical exposomics
KW  - metabolomics
KW  - suspect screening
KW  - nontargeted
UR  - https://pubs.acs.org/doi/10.1021/acs.est.3c04845
N2  - Adverse effects associated with chemical exposures during pregnancy include several developmental and reproductive disorders. However, considering the tens of thousands of chemicals present on the market, the effects of chemical mixtures on the developing fetus is still likely underestimated. In this critical review, we discuss the potential to apply innovative biomonitoring methods using high-resolution mass spectrometry (HRMS) on placenta to improve the monitoring of chemical exposure during pregnancy. The physiology of the placenta and its relevance as a matrix for monitoring chemical exposures and their effects on fetal health is first outlined. We then identify several key parameters that require further investigations before placenta can be used for large-scale monitoring in a robust manner. Most critical is the need for standardization of placental sampling. Placenta is a highly heterogeneous organ, and knowledge of the intraplacenta variability of chemical composition is required to ensure unbiased and robust interindividual comparisons. Other important variables include the time of collection, the sex of the fetus, and mode of delivery. Finally, we discuss the first applications of HRMS methods on the placenta to decipher the chemical exposome and describe how the use of placenta can complement biofluids collected on the mother or the fetus.
ER  -

CONTINI, Thomas Angelo Adrien, Remi BERANGER, Luc MULTIGNER, Jana KLÁNOVÁ, Elliott James PRICE a Arthur DAVID. A Critical Review on the Opportunity to Use Placenta and Innovative Biomonitoring Methods to Characterize the Prenatal Chemical Exposome. \textit{ENVIRONMENTAL SCIENCE \&{}amp; TECHNOLOGY}. WASHINGTON: AMER CHEMICAL SOC, 2023, roč.~57, č.~41, s.~15301-15313. ISSN~0013-936X. Dostupné z: https://dx.doi.org/10.1021/acs.est.3c04845.

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