The evolving landscape of COVID-19 and post-COVID condition in patients with chronic lymphocytic leukemia: A study by ERIC, the European research initiative on CLL
The evolving landscape of COVID-19 and post-COVID condition in patients with chronic lymphocytic leukemia: A study by ERIC, the European research initiative on CLL
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VISENTIN, Andrea, Thomas CHATZIKONSTANTINOU, Lydia SCARFÒ, Anargyros KAPETANAKIS, Christos DEMOSTHENOUS, Georgios KARAKATSOULIS, Eva MINGA, Dimitra CHAMOU, David ALLSUP, Alejandro Alonso CABRERO, Martin ANDRES, Darko ANTIC, Mónica BAILE, Panagiotis BALIAKAS, Sotiria BESIKLI-DIMOU, Dominique BRON, Sofia CHATZILEONTIADOU, Raul CORDOBA, Correa JUAN-GONZALO, Carolina CUÉLLAR-GARCÍA, Lorenzo De PAOLI, Maria Rosaria De PAOLIS, Julio DELGADO, Maria DIMOU, David DONALDSON, Mark CATHERWOOD, Michael DOUBEK (203 Česká republika, domácí), Maria EFSTATHOPOULOU, Barbara EICHHORST, Salma ELASHWAH, Alicia ENRICO, Blanca ESPINET, Lucia FARINA, Angela FERRARI, Myriam FOGLIETTA, Henrik FREDERIKSEN, Moritz FÜRSTENAU, José A GARCÍA-MARCO, Rocío GARCÍA-SERRA, Rosa COLLADO, Massimo GENTILE, Eva GIMENO, Andreas GLENTHØJ, Maria Gomes da SILVA, Yervand K HAKOBYAN, Yair HERISHANU, José Ángel HERNÁNDEZ-RIVAS, Tobias HEROLD, Idanna INNOCENTI, Gilad ITCHAKI, Ozren JAKSIC, Ann JANSSENS, Оlga B KALASHNIKOVA, Elżbieta KALICIŃSKA, Arnon P KATER, Sabina KERSTING, Jorge LABRADOR, Deepesh LAD, Luca LAURENTI, Levin MARK-DAVID, Enrico LISTA, Alberto LOPEZ-GARCIA, Lara MALERBA, Roberto MARASCA, Monia MARCHETTI, Juan MARQUET, Mattias MATTSSON, Francesca R MAURO, Marta MORAWSKA, Marina MOTTA, Talha MUNIR, Roberta MURRU, Carsten U NIEMANN, Raquel Nunes RODRIGUES, Jacopo OLIVIERI, Lorella ORSUCCI, Maria PAPAIOANNOU, Miguel Arturo PAVLOVSKY, Inga PISKUNOVA, Viola Maria POPOV, Francesca Maria QUAGLIA, Giulia QUARESMINI, Kristian QVIST, Gian Matteo RIGOLIN, Rosa RUCHLEMER, Martin ŠIMKOVIČ, Martin ŠPAČEK, Paolo SPORTOLETTI, Oana STANCA, Tamar TADMOR, Antonella CAPASSO, Giovanni Del POETA, Odit GUTWEIN, Linda Katharina KARLSSON, Ivana MILOSEVIC, Fatima MIRÁS, Gianluigi REDA, Gevorg SAGHUMYAN, Amit SHRESTHA, Doreen Te RAA, Sanne H TONINO, Ellen Van Der SPEK, Michel van GELDER, Roel van KAMPEN, Ewa WASIK-SZCZEPANEK, Tomasz WRÓBEL, Lucrecia Yáñez San SEGUNDO, Mohamed YASSIN, Barbara POCALI, Elisabeth VANDENBERGHE, Sunil IYENGAR, Marzia VARETTONI, Candida VITALE, Marta COSCIA, Alessandro RAMBALDI, Emili MONTSERRAT, Antonio CUNEO, Niki STAVROYIANNI, Livio TRENTIN, Kostas STAMATOPOULOS a Paolo GHIA
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American Journal of Hematology, Hoboken, Wiley-Blackwell, 2023, 0361-8609
In this retrospective international multicenter study, we describe the clinical characteristics and outcomes of patients with chronic lymphocytic leukemia (CLL) and related disorders (small lymphocytic lymphoma and high-count monoclonal B lymphocytosis) infected by SARS-CoV-2, including the development of post-COVID condition. Data from 1540 patients with CLL infected by SARS-CoV-2 from January 2020 to May 2022 were included in the analysis and assigned to four phases based on cases disposition and SARS-CoV-2 variants emergence. Post-COVID condition was defined according to the WHO criteria. Patients infected during the most recent phases of the pandemic, though carrying a higher comorbidity burden, were less often hospitalized, rarely needed intensive care unit admission, or died compared to patients infected during the initial phases. The 4-month overall survival (OS) improved through the phases, from 68% to 83%, p = .0015. Age, comorbidity, CLL-directed treatment, but not vaccination status, emerged as risk factors for mortality. Among survivors, 6.65% patients had a reinfection, usually milder than the initial one, and 16.5% developed post-COVID condition. The latter was characterized by fatigue, dyspnea, lasting cough, and impaired concentration. Infection severity was the only risk factor for developing post-COVID. The median time to resolution of the post-COVID condition was 4.7 months. OS in patients with CLL improved during the different phases of the pandemic, likely due to the improvement of prophylactic and therapeutic measures against SARS-CoV-2 as well as the emergence of milder variants. However, mortality remained relevant and a significant number of patients developed post-COVID conditions, warranting further investigations.
VISENTIN, Andrea, Thomas CHATZIKONSTANTINOU, Lydia SCARFÒ, Anargyros KAPETANAKIS, Christos DEMOSTHENOUS, Georgios KARAKATSOULIS, Eva MINGA, Dimitra CHAMOU, David ALLSUP, Alejandro Alonso CABRERO, Martin ANDRES, Darko ANTIC, Mónica BAILE, Panagiotis BALIAKAS, Sotiria BESIKLI-DIMOU, Dominique BRON, Sofia CHATZILEONTIADOU, Raul CORDOBA, Correa JUAN-GONZALO, Carolina CUÉLLAR-GARCÍA, Lorenzo De PAOLI, Maria Rosaria De PAOLIS, Julio DELGADO, Maria DIMOU, David DONALDSON, Mark CATHERWOOD, Michael DOUBEK, Maria EFSTATHOPOULOU, Barbara EICHHORST, Salma ELASHWAH, Alicia ENRICO, Blanca ESPINET, Lucia FARINA, Angela FERRARI, Myriam FOGLIETTA, Henrik FREDERIKSEN, Moritz FÜRSTENAU, José A GARCÍA-MARCO, Rocío GARCÍA-SERRA, Rosa COLLADO, Massimo GENTILE, Eva GIMENO, Andreas GLENTHØJ, Maria Gomes da SILVA, Yervand K HAKOBYAN, Yair HERISHANU, José Ángel HERNÁNDEZ-RIVAS, Tobias HEROLD, Idanna INNOCENTI, Gilad ITCHAKI, Ozren JAKSIC, Ann JANSSENS, Оlga B KALASHNIKOVA, Elżbieta KALICIŃSKA, Arnon P KATER, Sabina KERSTING, Jorge LABRADOR, Deepesh LAD, Luca LAURENTI, Levin MARK-DAVID, Enrico LISTA, Alberto LOPEZ-GARCIA, Lara MALERBA, Roberto MARASCA, Monia MARCHETTI, Juan MARQUET, Mattias MATTSSON, Francesca R MAURO, Marta MORAWSKA, Marina MOTTA, Talha MUNIR, Roberta MURRU, Carsten U NIEMANN, Raquel Nunes RODRIGUES, Jacopo OLIVIERI, Lorella ORSUCCI, Maria PAPAIOANNOU, Miguel Arturo PAVLOVSKY, Inga PISKUNOVA, Viola Maria POPOV, Francesca Maria QUAGLIA, Giulia QUARESMINI, Kristian QVIST, Gian Matteo RIGOLIN, Rosa RUCHLEMER, Martin ŠIMKOVIČ, Martin ŠPAČEK, Paolo SPORTOLETTI, Oana STANCA, Tamar TADMOR, Antonella CAPASSO, Giovanni Del POETA, Odit GUTWEIN, Linda Katharina KARLSSON, Ivana MILOSEVIC, Fatima MIRÁS, Gianluigi REDA, Gevorg SAGHUMYAN, Amit SHRESTHA, Doreen Te RAA, Sanne H TONINO, Ellen Van Der SPEK, Michel van GELDER, Roel van KAMPEN, Ewa WASIK-SZCZEPANEK, Tomasz WRÓBEL, Lucrecia Yáñez San SEGUNDO, Mohamed YASSIN, Barbara POCALI, Elisabeth VANDENBERGHE, Sunil IYENGAR, Marzia VARETTONI, Candida VITALE, Marta COSCIA, Alessandro RAMBALDI, Emili MONTSERRAT, Antonio CUNEO, Niki STAVROYIANNI, Livio TRENTIN, Kostas STAMATOPOULOS a Paolo GHIA. The evolving landscape of COVID-19 and post-COVID condition in patients with chronic lymphocytic leukemia: A study by ERIC, the European research initiative on CLL. American Journal of Hematology. Hoboken: Wiley-Blackwell, 2023, roč. 98, č. 12, s. 1856-1868. ISSN 0361-8609. Dostupné z: https://dx.doi.org/10.1002/ajh.27093.
@article{2365493, author = {Visentin, Andrea and Chatzikonstantinou, Thomas and Scarfò, Lydia and Kapetanakis, Anargyros and Demosthenous, Christos and Karakatsoulis, Georgios and Minga, Eva and Chamou, Dimitra and Allsup, David and Cabrero, Alejandro Alonso and Andres, Martin and Antic, Darko and Baile, Mónica and Baliakas, Panagiotis and BesikliandDimou, Sotiria and Bron, Dominique and Chatzileontiadou, Sofia and Cordoba, Raul and JuanandGonzalo, Correa and CuéllarandGarcía, Carolina and Paoli, Lorenzo De and Paolis, Maria Rosaria De and Delgado, Julio and Dimou, Maria and Donaldson, David and Catherwood, Mark and Doubek, Michael and Efstathopoulou, Maria and Eichhorst, Barbara and Elashwah, Salma and Enrico, Alicia and Espinet, Blanca and Farina, Lucia and Ferrari, Angela and Foglietta, Myriam and Frederiksen, Henrik and Fürstenau, Moritz and GarcíaandMarco, José A and GarcíaandSerra, Rocío and Collado, Rosa and Gentile, Massimo and Gimeno, Eva and Glenthøj, Andreas and Silva, Maria Gomes da and Hakobyan, Yervand K and Herishanu, Yair and HernándezandRivas, José Ángel and Herold, Tobias and Innocenti, Idanna and Itchaki, Gilad and Jaksic, Ozren and Janssens, Ann and Kalashnikova, Оlga B and Kalicińska, Elżbieta and Kater, Arnon P and Kersting, Sabina and Labrador, Jorge and Lad, Deepesh and Laurenti, Luca and MarkandDavid, Levin and Lista, Enrico and LopezandGarcia, Alberto and Malerba, Lara and Marasca, Roberto and Marchetti, Monia and Marquet, Juan and Mattsson, Mattias and Mauro, Francesca R and Morawska, Marta and Motta, Marina and Munir, Talha and Murru, Roberta and Niemann, Carsten U and Rodrigues, Raquel Nunes and Olivieri, Jacopo and Orsucci, Lorella and Papaioannou, Maria and Pavlovsky, Miguel Arturo and Piskunova, Inga and Popov, Viola Maria and Quaglia, Francesca Maria and Quaresmini, Giulia and Qvist, Kristian and Rigolin, Gian Matteo and Ruchlemer, Rosa and Šimkovič, Martin and Špaček, Martin and Sportoletti, Paolo and Stanca, Oana and Tadmor, Tamar and Capasso, Antonella and Poeta, Giovanni Del and Gutwein, Odit and Karlsson, Linda Katharina and Milosevic, Ivana and Mirás, Fatima and Reda, Gianluigi and Saghumyan, Gevorg and Shrestha, Amit and Raa, Doreen Te and Tonino, Sanne H and Spek, Ellen Van Der and Gelder, Michel van and Kampen, Roel van and WasikandSzczepanek, Ewa and Wróbel, Tomasz and Segundo, Lucrecia Yáñez San and Yassin, Mohamed and Pocali, Barbara and Vandenberghe, Elisabeth and Iyengar, Sunil and Varettoni, Marzia and Vitale, Candida and Coscia, Marta and Rambaldi, Alessandro and Montserrat, Emili and Cuneo, Antonio and Stavroyianni, Niki and Trentin, Livio and Stamatopoulos, Kostas and Ghia, Paolo}, article_location = {Hoboken}, article_number = {12}, doi = {http://dx.doi.org/10.1002/ajh.27093}, keywords = {COVID-19; post-COVID condition; chronic lymphocytic leukemia}, language = {eng}, issn = {0361-8609}, journal = {American Journal of Hematology}, title = {The evolving landscape of COVID-19 and post-COVID condition in patients with chronic lymphocytic leukemia: A study by ERIC, the European research initiative on CLL}, url = {https://onlinelibrary.wiley.com/doi/10.1002/ajh.27093}, volume = {98}, year = {2023} }
TY - JOUR ID - 2365493 AU - Visentin, Andrea - Chatzikonstantinou, Thomas - Scarfò, Lydia - Kapetanakis, Anargyros - Demosthenous, Christos - Karakatsoulis, Georgios - Minga, Eva - Chamou, Dimitra - Allsup, David - Cabrero, Alejandro Alonso - Andres, Martin - Antic, Darko - Baile, Mónica - Baliakas, Panagiotis - Besikli-Dimou, Sotiria - Bron, Dominique - Chatzileontiadou, Sofia - Cordoba, Raul - Juan-Gonzalo, Correa - Cuéllar-García, Carolina - Paoli, Lorenzo De - Paolis, Maria Rosaria De - Delgado, Julio - Dimou, Maria - Donaldson, David - Catherwood, Mark - Doubek, Michael - Efstathopoulou, Maria - Eichhorst, Barbara - Elashwah, Salma - Enrico, Alicia - Espinet, Blanca - Farina, Lucia - Ferrari, Angela - Foglietta, Myriam - Frederiksen, Henrik - Fürstenau, Moritz - García-Marco, José A - García-Serra, Rocío - Collado, Rosa - Gentile, Massimo - Gimeno, Eva - Glenthøj, Andreas - Silva, Maria Gomes da - Hakobyan, Yervand K - Herishanu, Yair - Hernández-Rivas, José Ángel - Herold, Tobias - Innocenti, Idanna - Itchaki, Gilad - Jaksic, Ozren - Janssens, Ann - Kalashnikova, Оlga B - Kalicińska, Elżbieta - Kater, Arnon P - Kersting, Sabina - Labrador, Jorge - Lad, Deepesh - Laurenti, Luca - Mark-David, Levin - Lista, Enrico - Lopez-Garcia, Alberto - Malerba, Lara - Marasca, Roberto - Marchetti, Monia - Marquet, Juan - Mattsson, Mattias - Mauro, Francesca R - Morawska, Marta - Motta, Marina - Munir, Talha - Murru, Roberta - Niemann, Carsten U - Rodrigues, Raquel Nunes - Olivieri, Jacopo - Orsucci, Lorella - Papaioannou, Maria - Pavlovsky, Miguel Arturo - Piskunova, Inga - Popov, Viola Maria - Quaglia, Francesca Maria - Quaresmini, Giulia - Qvist, Kristian - Rigolin, Gian Matteo - Ruchlemer, Rosa - Šimkovič, Martin - Špaček, Martin - Sportoletti, Paolo - Stanca, Oana - Tadmor, Tamar - Capasso, Antonella - Poeta, Giovanni Del - Gutwein, Odit - Karlsson, Linda Katharina - Milosevic, Ivana - Mirás, Fatima - Reda, Gianluigi - Saghumyan, Gevorg - Shrestha, Amit - Raa, Doreen Te - Tonino, Sanne H - Spek, Ellen Van Der - Gelder, Michel van - Kampen, Roel van - Wasik-Szczepanek, Ewa - Wróbel, Tomasz - Segundo, Lucrecia Yáñez San - Yassin, Mohamed - Pocali, Barbara - Vandenberghe, Elisabeth - Iyengar, Sunil - Varettoni, Marzia - Vitale, Candida - Coscia, Marta - Rambaldi, Alessandro - Montserrat, Emili - Cuneo, Antonio - Stavroyianni, Niki - Trentin, Livio - Stamatopoulos, Kostas - Ghia, Paolo PY - 2023 TI - The evolving landscape of COVID-19 and post-COVID condition in patients with chronic lymphocytic leukemia: A study by ERIC, the European research initiative on CLL JF - American Journal of Hematology VL - 98 IS - 12 SP - 1856-1868 EP - 1856-1868 PB - Wiley-Blackwell SN - 03618609 KW - COVID-19 KW - post-COVID condition KW - chronic lymphocytic leukemia UR - https://onlinelibrary.wiley.com/doi/10.1002/ajh.27093 N2 - In this retrospective international multicenter study, we describe the clinical characteristics and outcomes of patients with chronic lymphocytic leukemia (CLL) and related disorders (small lymphocytic lymphoma and high-count monoclonal B lymphocytosis) infected by SARS-CoV-2, including the development of post-COVID condition. Data from 1540 patients with CLL infected by SARS-CoV-2 from January 2020 to May 2022 were included in the analysis and assigned to four phases based on cases disposition and SARS-CoV-2 variants emergence. Post-COVID condition was defined according to the WHO criteria. Patients infected during the most recent phases of the pandemic, though carrying a higher comorbidity burden, were less often hospitalized, rarely needed intensive care unit admission, or died compared to patients infected during the initial phases. The 4-month overall survival (OS) improved through the phases, from 68% to 83%, p = .0015. Age, comorbidity, CLL-directed treatment, but not vaccination status, emerged as risk factors for mortality. Among survivors, 6.65% patients had a reinfection, usually milder than the initial one, and 16.5% developed post-COVID condition. The latter was characterized by fatigue, dyspnea, lasting cough, and impaired concentration. Infection severity was the only risk factor for developing post-COVID. The median time to resolution of the post-COVID condition was 4.7 months. OS in patients with CLL improved during the different phases of the pandemic, likely due to the improvement of prophylactic and therapeutic measures against SARS-CoV-2 as well as the emergence of milder variants. However, mortality remained relevant and a significant number of patients developed post-COVID conditions, warranting further investigations. ER -
VISENTIN, Andrea, Thomas CHATZIKONSTANTINOU, Lydia SCARFÒ, Anargyros KAPETANAKIS, Christos DEMOSTHENOUS, Georgios KARAKATSOULIS, Eva MINGA, Dimitra CHAMOU, David ALLSUP, Alejandro Alonso CABRERO, Martin ANDRES, Darko ANTIC, Mónica BAILE, Panagiotis BALIAKAS, Sotiria BESIKLI-DIMOU, Dominique BRON, Sofia CHATZILEONTIADOU, Raul CORDOBA, Correa JUAN-GONZALO, Carolina CUÉLLAR-GARCÍA, Lorenzo De PAOLI, Maria Rosaria De PAOLIS, Julio DELGADO, Maria DIMOU, David DONALDSON, Mark CATHERWOOD, Michael DOUBEK, Maria EFSTATHOPOULOU, Barbara EICHHORST, Salma ELASHWAH, Alicia ENRICO, Blanca ESPINET, Lucia FARINA, Angela FERRARI, Myriam FOGLIETTA, Henrik FREDERIKSEN, Moritz FÜRSTENAU, José A GARCÍA-MARCO, Rocío GARCÍA-SERRA, Rosa COLLADO, Massimo GENTILE, Eva GIMENO, Andreas GLENTHØJ, Maria Gomes da SILVA, Yervand K HAKOBYAN, Yair HERISHANU, José Ángel HERNÁNDEZ-RIVAS, Tobias HEROLD, Idanna INNOCENTI, Gilad ITCHAKI, Ozren JAKSIC, Ann JANSSENS, Оlga B KALASHNIKOVA, El$\backslash$.zbieta KALICI$\backslash$'NSKA, Arnon P KATER, Sabina KERSTING, Jorge LABRADOR, Deepesh LAD, Luca LAURENTI, Levin MARK-DAVID, Enrico LISTA, Alberto LOPEZ-GARCIA, Lara MALERBA, Roberto MARASCA, Monia MARCHETTI, Juan MARQUET, Mattias MATTSSON, Francesca R MAURO, Marta MORAWSKA, Marina MOTTA, Talha MUNIR, Roberta MURRU, Carsten U NIEMANN, Raquel Nunes RODRIGUES, Jacopo OLIVIERI, Lorella ORSUCCI, Maria PAPAIOANNOU, Miguel Arturo PAVLOVSKY, Inga PISKUNOVA, Viola Maria POPOV, Francesca Maria QUAGLIA, Giulia QUARESMINI, Kristian QVIST, Gian Matteo RIGOLIN, Rosa RUCHLEMER, Martin ŠIMKOVIČ, Martin ŠPAČEK, Paolo SPORTOLETTI, Oana STANCA, Tamar TADMOR, Antonella CAPASSO, Giovanni Del POETA, Odit GUTWEIN, Linda Katharina KARLSSON, Ivana MILOSEVIC, Fatima MIRÁS, Gianluigi REDA, Gevorg SAGHUMYAN, Amit SHRESTHA, Doreen Te RAA, Sanne H TONINO, Ellen Van Der SPEK, Michel van GELDER, Roel van KAMPEN, Ewa WASIK-SZCZEPANEK, Tomasz WRÓBEL, Lucrecia Yáñez San SEGUNDO, Mohamed YASSIN, Barbara POCALI, Elisabeth VANDENBERGHE, Sunil IYENGAR, Marzia VARETTONI, Candida VITALE, Marta COSCIA, Alessandro RAMBALDI, Emili MONTSERRAT, Antonio CUNEO, Niki STAVROYIANNI, Livio TRENTIN, Kostas STAMATOPOULOS a Paolo GHIA. The evolving landscape of COVID-19 and post-COVID condition in patients with chronic lymphocytic leukemia: A study by ERIC, the European research initiative on CLL. \textit{American Journal of Hematology}. Hoboken: Wiley-Blackwell, 2023, roč.~98, č.~12, s.~1856-1868. ISSN~0361-8609. Dostupné z: https://dx.doi.org/10.1002/ajh.27093.