Neural correlates of social exclusion and overinclusion in
patients with borderline personality disorder: an fMRI study

J 2023

Neural correlates of social exclusion and overinclusion in patients with borderline personality disorder: an fMRI study

LÁTALOVÁ, Adéla, Monika RADIMECKÁ, Martin LAMOŠ, Martin JÁNI, Alena DAMBORSKÁ et. al.

Základní údaje

Originální název

Neural correlates of social exclusion and overinclusion in patients with borderline personality disorder: an fMRI study

Autoři

LÁTALOVÁ, Adéla (203 Česká republika, domácí), Monika RADIMECKÁ (203 Česká republika, domácí), Martin LAMOŠ (203 Česká republika, domácí), Martin JÁNI (703 Slovensko, domácí), Alena DAMBORSKÁ (203 Česká republika, domácí), Pavel THEINER (203 Česká republika, domácí), Eliška BARTEČKOVÁ (203 Česká republika, domácí), Patrik BARTYS (203 Česká republika, domácí), Helena VLČKOVÁ (203 Česká republika, domácí), Katarína ŠKOLIAKOVÁ (703 Slovensko, domácí), Tomáš KAŠPÁREK (203 Česká republika, domácí) a Pavla LINHARTOVÁ (203 Česká republika, domácí)

Vydání

BORDERLINE PERSONALITY DISORDER AND EMOTION DYSREGULATION, LONDON, BMC, 2023, 2051-6673

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30215 Psychiatry

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.100 v roce 2022

Kód RIV

RIV/00216224:14110/23:00133227

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1186/s40479-023-00240-1

UT WoS

001111419800001

Klíčová slova anglicky

Borderline personality disorder; Rejection sensitivity; Social exclusion; Social overinclusion; Cyberball paradigm; fMRI

Štítky

14110222, CF MAFIL, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 10. 10. 2024 10:51, Ing. Jana Kuchtová

Anotace

V originále

BackgroundInterpersonal difficulties of patients with borderline personality disorder (BPD) are closely related to rejection sensitivity. The aim of the present study was to gain further insight into the experience and cerebral processing of social interactions in patients with BPD by using fMRI during experimentally induced experiences of social exclusion, inclusion, and overinclusion.MethodsThe study involved 30 participants diagnosed with BPD (29 female and 1 male; age: M = 24.22, SD = 5.22) and 30 healthy controls (29 female and 1 male; age: M = 24.66, SD = 5.28) with no current or lifetime psychiatric diagnoses. In the fMRI session, all participants were asked to complete a Cyberball task that consisted of an alternating sequence of inclusion, exclusion, and overinclusion conditions.ResultsCompared to healthy controls, participants with BPD reported higher levels of inner tension and more unpleasant emotions across all experimental conditions. At the neural level, the participants with BPD showed lower recruitment of the left hippocampus in response to social exclusion (relative to the inclusion condition) than the healthy controls did. Lower recruitment of the left hippocampus in this contrast was associated with childhood maltreatment in patients with BPD. However, this difference was no longer significant when we added the covariate of hippocampal volume to the analysis. During social overinclusion (relative to the inclusion condition), we observed no significant differences in a group comparison of neural activation.ConclusionsThe results of our study suggest that patients with BPD experience more discomfort than do healthy controls during social interactions. Compared to healthy participants, patients with BPD reported more inner tension and unpleasant emotions, irrespective of the extent to which others included them in social interactions. At a neural level, the participants with BPD showed a lower recruitment of the left hippocampus in response to social exclusion than the healthy controls did. The reduced activation of this neural structure could be related to a history of childhood maltreatment and smaller hippocampal volume in patients with BPD.

Návaznosti

NU20-04-00410, projekt VaV

Název: Neurální mechanismy dialektické behaviorální terapie u pacientů s hraniční poruchou osobnosti (Akronym: NU20-04-00410)

Investor: Ministerstvo zdravotnictví ČR, Neurální mechanismy dialektické behaviorální terapie u pacientů s hraniční poruchou osobnosti, Podprogram 1 - standardní

90250, velká výzkumná infrastruktura

Název: Czech-BioImaging III

Citovat

LÁTALOVÁ, Adéla, Monika RADIMECKÁ, Martin LAMOŠ, Martin JÁNI, Alena DAMBORSKÁ, Pavel THEINER, Eliška BARTEČKOVÁ, Patrik BARTYS, Helena VLČKOVÁ, Katarína ŠKOLIAKOVÁ, Tomáš KAŠPÁREK a Pavla LINHARTOVÁ. Neural correlates of social exclusion and overinclusion in patients with borderline personality disorder: an fMRI study. BORDERLINE PERSONALITY DISORDER AND EMOTION DYSREGULATION. LONDON: BMC, 2023, roč. 10, č. 1, s. 1-14. ISSN 2051-6673. Dostupné z: https://dx.doi.org/10.1186/s40479-023-00240-1.

@article{2365644,
   author = {Látalová, Adéla and Radimecká, Monika and Lamoš, Martin and Jáni, Martin and Damborská, Alena and Theiner, Pavel and Bartečková, Eliška and Bartys, Patrik and Vlčková, Helena and Školiaková, Katarína and Kašpárek, Tomáš and Linhartová, Pavla},
   article_location = {LONDON},
   article_number = {1},
   doi = {http://dx.doi.org/10.1186/s40479-023-00240-1},
   keywords = {Borderline personality disorder; Rejection sensitivity; Social exclusion; Social overinclusion; Cyberball paradigm; fMRI},
   language = {eng},
   issn = {2051-6673},
   journal = {BORDERLINE PERSONALITY DISORDER AND EMOTION DYSREGULATION},
   title = {Neural correlates of social exclusion and overinclusion in patients with borderline personality disorder: an fMRI study},
   url = {https://bpded.biomedcentral.com/articles/10.1186/s40479-023-00240-1},
   volume = {10},
   year = {2023}
}

TY  - JOUR
ID  - 2365644
AU  - Látalová, Adéla - Radimecká, Monika - Lamoš, Martin - Jáni, Martin - Damborská, Alena - Theiner, Pavel - Bartečková, Eliška - Bartys, Patrik - Vlčková, Helena - Školiaková, Katarína - Kašpárek, Tomáš - Linhartová, Pavla
PY  - 2023
TI  - Neural correlates of social exclusion and overinclusion in patients with borderline personality disorder: an fMRI study
JF  - BORDERLINE PERSONALITY DISORDER AND EMOTION DYSREGULATION
VL  - 10
IS  - 1
SP  - 1-14
EP  - 1-14
PB  - BMC
SN  - 20516673
KW  - Borderline personality disorder
KW  - Rejection sensitivity
KW  - Social exclusion
KW  - Social overinclusion
KW  - Cyberball paradigm
KW  - fMRI
UR  - https://bpded.biomedcentral.com/articles/10.1186/s40479-023-00240-1
N2  - BackgroundInterpersonal difficulties of patients with borderline personality disorder (BPD) are closely related to rejection sensitivity. The aim of the present study was to gain further insight into the experience and cerebral processing of social interactions in patients with BPD by using fMRI during experimentally induced experiences of social exclusion, inclusion, and overinclusion.MethodsThe study involved 30 participants diagnosed with BPD (29 female and 1 male; age: M = 24.22, SD = 5.22) and 30 healthy controls (29 female and 1 male; age: M = 24.66, SD = 5.28) with no current or lifetime psychiatric diagnoses. In the fMRI session, all participants were asked to complete a Cyberball task that consisted of an alternating sequence of inclusion, exclusion, and overinclusion conditions.ResultsCompared to healthy controls, participants with BPD reported higher levels of inner tension and more unpleasant emotions across all experimental conditions. At the neural level, the participants with BPD showed lower recruitment of the left hippocampus in response to social exclusion (relative to the inclusion condition) than the healthy controls did. Lower recruitment of the left hippocampus in this contrast was associated with childhood maltreatment in patients with BPD. However, this difference was no longer significant when we added the covariate of hippocampal volume to the analysis. During social overinclusion (relative to the inclusion condition), we observed no significant differences in a group comparison of neural activation.ConclusionsThe results of our study suggest that patients with BPD experience more discomfort than do healthy controls during social interactions. Compared to healthy participants, patients with BPD reported more inner tension and unpleasant emotions, irrespective of the extent to which others included them in social interactions. At a neural level, the participants with BPD showed a lower recruitment of the left hippocampus in response to social exclusion than the healthy controls did. The reduced activation of this neural structure could be related to a history of childhood maltreatment and smaller hippocampal volume in patients with BPD.
ER  -

LÁTALOVÁ, Adéla, Monika RADIMECKÁ, Martin LAMOŠ, Martin JÁNI, Alena DAMBORSKÁ, Pavel THEINER, Eliška BARTEČKOVÁ, Patrik BARTYS, Helena VLČKOVÁ, Katarína ŠKOLIAKOVÁ, Tomáš KAŠPÁREK a Pavla LINHARTOVÁ. Neural correlates of social exclusion and overinclusion in patients with borderline personality disorder: an fMRI study. \textit{BORDERLINE PERSONALITY DISORDER AND EMOTION DYSREGULATION}. LONDON: BMC, 2023, roč.~10, č.~1, s.~1-14. ISSN~2051-6673. Dostupné z: https://dx.doi.org/10.1186/s40479-023-00240-1.

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