Early-onset pancreatic cancer: A national cancer registry study
from the Czech Republic and review of the literature

J 2023

Early-onset pancreatic cancer: A national cancer registry study from the Czech Republic and review of the literature

WHITLEY, Adam, Petr KOCIAN, Andrej NIKOV, Denisa KREJČÍ, Lucie KŮSOVÁ et. al.

Základní údaje

Originální název

Early-onset pancreatic cancer: A national cancer registry study from the Czech Republic and review of the literature

Autoři

WHITLEY, Adam, Petr KOCIAN (203 Česká republika, garant), Andrej NIKOV, Denisa KREJČÍ (203 Česká republika, domácí), Lucie KŮSOVÁ (203 Česká republika, domácí), Milan BLAHA (203 Česká republika, domácí), Ladislav DUŠEK (203 Česká republika, domácí) a Robert GURLICH (203 Česká republika)

Vydání

JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES, Hoboken, WILEY, 2023, 1868-6974

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30219 Gastroenterology and hepatology

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.000 v roce 2022

Kód RIV

RIV/00216224:14110/23:00133339

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1002/jhbp.1359

UT WoS

001073545100001

Klíčová slova anglicky

adult; pancreatic neoplasms; population register; survival; young adult

Štítky

14119612, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 5. 4. 2024 09:23, Mgr. Tereza Miškechová

Anotace

V originále

Background: The aim of this study was to compare trends in mortality and incidence, clinicopathological features and survival of patients diagnosed with pancreatic ductal adenocarcinoma under 50 years of age (early-onset pancreatic cancer [EOPC]) with patients diagnosed over 50 years of age (late-onset pancreatic cancer [LOPC]).Methods: The national oncological registry of the Czech Republic was reviewed to identify all patients with histologically confirmed pancreatic ductal adenocarcinoma diagnosed between the years 1985 and 2015. Incidence, mortality, clinicopathological and survival data were analyzed and compared between patients with EOPC and LOPC.Results: From a total of 18 888 patients included in the study, 1324 patients were under the age of 50 years (7.0%). The average annual percentage changes (AAPC) in incidence of all patients with EOPC was -1.0%. The APPC for male patients with EOPC was -2.0% and for female patients was +0.6%. The AAPC in incidence for LOPC was +1.3%. There were no differences in tumor stage, grade or location between EOPC and LOPC. Young patients were more frequently male (64.4% vs. 52.9%), more frequently underwent treatment and had better overall survival. The median survival interval for EOPC was 5.9 months and for LOPC was 4.5 months (p < .001).Conclusions: The clinicopathological features of pancreatic ductal adenocarcinoma were similar in patients under and over the age of 50 years. Patients with EOPC survived longer than patients with LOPC. Continued efforts should be made to diagnose early and treat young patients aggressively.

Citovat

WHITLEY, Adam, Petr KOCIAN, Andrej NIKOV, Denisa KREJČÍ, Lucie KŮSOVÁ, Milan BLAHA, Ladislav DUŠEK a Robert GURLICH. Early-onset pancreatic cancer: A national cancer registry study from the Czech Republic and review of the literature. JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES. Hoboken: WILEY, 2023, roč. 30, č. 12, s. 1324-1333. ISSN 1868-6974. Dostupné z: https://dx.doi.org/10.1002/jhbp.1359.

@article{2368020,
   author = {Whitley, Adam and Kocian, Petr and Nikov, Andrej and Krejčí, Denisa and Kůsová, Lucie and Blaha, Milan and Dušek, Ladislav and Gurlich, Robert},
   article_location = {Hoboken},
   article_number = {12},
   doi = {http://dx.doi.org/10.1002/jhbp.1359},
   keywords = {adult; pancreatic neoplasms; population register; survival; young adult},
   language = {eng},
   issn = {1868-6974},
   journal = {JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES},
   title = {Early-onset pancreatic cancer: A national cancer registry study from the Czech Republic and review of the literature},
   url = {https://onlinelibrary.wiley.com/doi/10.1002/jhbp.1359},
   volume = {30},
   year = {2023}
}

TY  - JOUR
ID  - 2368020
AU  - Whitley, Adam - Kocian, Petr - Nikov, Andrej - Krejčí, Denisa - Kůsová, Lucie - Blaha, Milan - Dušek, Ladislav - Gurlich, Robert
PY  - 2023
TI  - Early-onset pancreatic cancer: A national cancer registry study from the Czech Republic and review of the literature
JF  - JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
VL  - 30
IS  - 12
SP  - 1324-1333
EP  - 1324-1333
PB  - WILEY
SN  - 18686974
KW  - adult
KW  - pancreatic neoplasms
KW  - population register
KW  - survival
KW  - young adult
UR  - https://onlinelibrary.wiley.com/doi/10.1002/jhbp.1359
N2  - Background: The aim of this study was to compare trends in mortality and incidence, clinicopathological features and survival of patients diagnosed with pancreatic ductal adenocarcinoma under 50 years of age (early-onset pancreatic cancer [EOPC]) with patients diagnosed over 50 years of age (late-onset pancreatic cancer [LOPC]).Methods: The national oncological registry of the Czech Republic was reviewed to identify all patients with histologically confirmed pancreatic ductal adenocarcinoma diagnosed between the years 1985 and 2015. Incidence, mortality, clinicopathological and survival data were analyzed and compared between patients with EOPC and LOPC.Results: From a total of 18 888 patients included in the study, 1324 patients were under the age of 50 years (7.0%). The average annual percentage changes (AAPC) in incidence of all patients with EOPC was -1.0%. The APPC for male patients with EOPC was -2.0% and for female patients was +0.6%. The AAPC in incidence for LOPC was +1.3%. There were no differences in tumor stage, grade or location between EOPC and LOPC. Young patients were more frequently male (64.4% vs. 52.9%), more frequently underwent treatment and had better overall survival. The median survival interval for EOPC was 5.9 months and for LOPC was 4.5 months (p < .001).Conclusions: The clinicopathological features of pancreatic ductal adenocarcinoma were similar in patients under and over the age of 50 years. Patients with EOPC survived longer than patients with LOPC. Continued efforts should be made to diagnose early and treat young patients aggressively.
ER  -

WHITLEY, Adam, Petr KOCIAN, Andrej NIKOV, Denisa KREJČÍ, Lucie KŮSOVÁ, Milan BLAHA, Ladislav DUŠEK a Robert GURLICH. Early-onset pancreatic cancer: A national cancer registry study from the Czech Republic and review of the literature. \textit{JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES}. Hoboken: WILEY, 2023, roč.~30, č.~12, s.~1324-1333. ISSN~1868-6974. Dostupné z: https://dx.doi.org/10.1002/jhbp.1359.

Podrobný výpis o publikaci