ABCA3 and LZTFL1 Polymorphisms and Risk of COVID-19 in the Czech Population

HUBACEK, Jaroslav A., Tom PHILIPP, Vera ADAMKOVA, Ondřej MÁJEK and Ladislav DUŠEK. ABCA3 and LZTFL1 Polymorphisms and Risk of COVID-19 in the Czech Population. Physiological research. Praha: Institute of Physiology of the Czechoslovak Academy of Sciences, 2023, vol. 72, No 4, p. 539-543. ISSN 0862-8408. Available from: https://dx.doi.org/10.33549/physiolres.935108.

Basic information

• Original name: ABCA3 and LZTFL1 Polymorphisms and Risk of COVID-19 in the Czech Population
• Authors: HUBACEK, Jaroslav A. (203 Czech Republic), Tom PHILIPP (203 Czech Republic), Vera ADAMKOVA (203 Czech Republic), Ondřej MÁJEK (203 Czech Republic, belonging to the institution) and Ladislav DUŠEK (203 Czech Republic, belonging to the institution).
• Edition: Physiological research, Praha, Institute of Physiology of the Czechoslovak Academy of Sciences, 2023, 0862-8408.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30105 Physiology
• Country of publisher: Czech Republic
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• Impact factor: Impact factor: 2.100 in 2022
• RIV identification code: RIV/00216224:14110/23:00133355
• Organization unit: Faculty of Medicine
• Doi: http://dx.doi.org/10.33549/physiolres.935108
• UT WoS: 001078316100012
• Keywords in English: COVID-19; LZTFL1; ABCA3; Polymorphism; Susceptibility
• Tags: 14119612, rivok

Abstract

SARS-CoV-2 infection, which causes the respiratory disease COVID-19, has spread rapidly from Wuhan, China, since 2019, causing nearly 7 million deaths worldwide in three years. In addition to clinical risk factors such as diabetes, hypertension, and obesity, genetic variability is an important predictor of disease severity and susceptibility. We analyzed common polymorphisms within the LZTFL1 (rs11385942) and ABCA3 (rs13332514) genes in 519 SARS-CoV-2-positive subjects (164 asymptomatic, 246 symptomatic, and 109 hospitalized COVID-19 survivors) and a population-based control group (N = 2,592; COVID-19 status unknown). Rare ABCA3 AA homozygotes (but not A allele carriers) may be at a significantly increased risk of SARS-CoV-2 infection [P = 0.003; OR (95 % CI); 3.66 (1.47-9.15)]. We also observed a borderline significant difference in the genotype distribution of the LZTFL1 rs11385942 polymorphism (P = 0.04) between the population sample and SARS-CoV-2-positive subjects. In agreement with previous studies, a nonsignificantly higher frequency of minor allele carriers was detected among hospitalized COVID-19 subjects. We conclude that a common polymorphism in the ABCA3 gene may be a significant predictor of susceptibility to SARS-CoV-2 infection.