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@article{2368187,
author = {Hubacek, Jaroslav A. and Philipp, Tom and Adamkova, Vera and Májek, Ondřej and Dušek, Ladislav},
article_location = {Praha},
article_number = {4},
doi = {http://dx.doi.org/10.33549/physiolres.935108},
keywords = {COVID-19; LZTFL1; ABCA3; Polymorphism; Susceptibility},
language = {eng},
issn = {0862-8408},
journal = {Physiological research},
title = {ABCA3 and LZTFL1 Polymorphisms and Risk of COVID-19 in the Czech Population},
url = {https://www.biomed.cas.cz/physiolres/pdf/2023/72_539.pdf},
volume = {72},
year = {2023}
}
TY - JOUR
ID - 2368187
AU - Hubacek, Jaroslav A. - Philipp, Tom - Adamkova, Vera - Májek, Ondřej - Dušek, Ladislav
PY - 2023
TI - ABCA3 and LZTFL1 Polymorphisms and Risk of COVID-19 in the Czech Population
JF - Physiological research
VL - 72
IS - 4
SP - 539-543
EP - 539-543
PB - Institute of Physiology of the Czechoslovak Academy of Sciences
SN - 08628408
KW - COVID-19
KW - LZTFL1
KW - ABCA3
KW - Polymorphism
KW - Susceptibility
UR - https://www.biomed.cas.cz/physiolres/pdf/2023/72_539.pdf
N2 - SARS-CoV-2 infection, which causes the respiratory disease COVID-19, has spread rapidly from Wuhan, China, since 2019, causing nearly 7 million deaths worldwide in three years. In addition to clinical risk factors such as diabetes, hypertension, and obesity, genetic variability is an important predictor of disease severity and susceptibility. We analyzed common polymorphisms within the LZTFL1 (rs11385942) and ABCA3 (rs13332514) genes in 519 SARS-CoV-2-positive subjects (164 asymptomatic, 246 symptomatic, and 109 hospitalized COVID-19 survivors) and a population-based control group (N = 2,592; COVID-19 status unknown). Rare ABCA3 AA homozygotes (but not A allele carriers) may be at a significantly increased risk of SARS-CoV-2 infection [P = 0.003; OR (95 % CI); 3.66 (1.47-9.15)]. We also observed a borderline significant difference in the genotype distribution of the LZTFL1 rs11385942 polymorphism (P = 0.04) between the population sample and SARS-CoV-2-positive subjects. In agreement with previous studies, a nonsignificantly higher frequency of minor allele carriers was detected among hospitalized COVID-19 subjects. We conclude that a common polymorphism in the ABCA3 gene may be a significant predictor of susceptibility to SARS-CoV-2 infection.
ER -
HUBACEK, Jaroslav A., Tom PHILIPP, Vera ADAMKOVA, Ondřej MÁJEK a Ladislav DUŠEK. ABCA3 and LZTFL1 Polymorphisms and Risk of COVID-19 in the Czech Population. \textit{Physiological research}. Praha: Institute of Physiology of the Czechoslovak Academy of Sciences, 2023, roč.~72, č.~4, s.~539-543. ISSN~0862-8408. Dostupné z: https://dx.doi.org/10.33549/physiolres.935108.
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