| VIOLANTE, Ines R, Ketevan ALANIA, Antonino M CASSARA, Esra NEUFELD, Emma ACERBO, Romain CARRON, Adam WILLIAMSON, Danielle L KURTIN, Edward RHODES, Adam HAMPSHIRE, Niels KUSTER, Edward S BOYDEN, Alvaro PASCUAL-LEONE a Nir GROSSMAN. Non-invasive temporal interference electrical stimulation of the human hippocampus. Nature Neuroscience. BERLIN: NATURE PUBLISHING GROUP, 2023, roč. 26, č. 11, s. 1994-2004, 24 s. ISSN 1097-6256. Dostupné z: https://dx.doi.org/10.1038/s41593-023-01456-8. |
Další formáty:
BibTeX
LaTeX
RIS
@article{2368979,
author = {Violante, Ines R and Alania, Ketevan and Cassara, Antonino M and Neufeld, Esra and Acerbo, Emma and Carron, Romain and Williamson, Adam and Kurtin, Danielle L and Rhodes, Edward and Hampshire, Adam and Kuster, Niels and Boyden, Edward S and PascualandLeone, Alvaro and Grossman, Nir},
article_location = {BERLIN},
article_number = {11},
doi = {http://dx.doi.org/10.1038/s41593-023-01456-8},
keywords = {human hippocampus; electrical stimulation},
language = {eng},
issn = {1097-6256},
journal = {Nature Neuroscience},
title = {Non-invasive temporal interference electrical stimulation of the human hippocampus},
url = {https://www.nature.com/articles/s41593-023-01456-8},
volume = {26},
year = {2023}
}
TY - JOUR
ID - 2368979
AU - Violante, Ines R - Alania, Ketevan - Cassara, Antonino M - Neufeld, Esra - Acerbo, Emma - Carron, Romain - Williamson, Adam - Kurtin, Danielle L - Rhodes, Edward - Hampshire, Adam - Kuster, Niels - Boyden, Edward S - Pascual-Leone, Alvaro - Grossman, Nir
PY - 2023
TI - Non-invasive temporal interference electrical stimulation of the human hippocampus
JF - Nature Neuroscience
VL - 26
IS - 11
SP - 1994-2004
EP - 1994-2004
PB - NATURE PUBLISHING GROUP
SN - 10976256
KW - human hippocampus
KW - electrical stimulation
UR - https://www.nature.com/articles/s41593-023-01456-8
N2 - Deep brain stimulation (DBS) via implanted electrodes is used worldwide to treat patients with severe neurological and psychiatric disorders. However, its invasiveness precludes widespread clinical use and deployment in research. Temporal interference (TI) is a strategy for non-invasive steerable DBS using multiple kHz-range electric fields with a difference frequency within the range of neural activity. Here we report the validation of the non-invasive DBS concept in humans. We used electric field modeling and measurements in a human cadaver to verify that the locus of the transcranial TI stimulation can be steerably focused in the hippocampus with minimal exposure to the overlying cortex. We then used functional magnetic resonance imaging and behavioral experiments to show that TI stimulation can focally modulate hippocampal activity and enhance the accuracy of episodic memories in healthy humans. Our results demonstrate targeted, non-invasive electrical stimulation of deep structures in the human brain.
ER -
VIOLANTE, Ines R, Ketevan ALANIA, Antonino M CASSARA, Esra NEUFELD, Emma ACERBO, Romain CARRON, Adam WILLIAMSON, Danielle L KURTIN, Edward RHODES, Adam HAMPSHIRE, Niels KUSTER, Edward S BOYDEN, Alvaro PASCUAL-LEONE a Nir GROSSMAN. Non-invasive temporal interference electrical stimulation of the human hippocampus. \textit{Nature Neuroscience}. BERLIN: NATURE PUBLISHING GROUP, 2023, roč.~26, č.~11, s.~1994-2004, 24 s. ISSN~1097-6256. Dostupné z: https://dx.doi.org/10.1038/s41593-023-01456-8.
|
