HORACEK, Jiri, Robert JANDA, Natalie GÖRNEROVA, Lucia JAJCAY a Veronika ANDRASHKO. Several reasons why ketamine as a neuroplastic agent may have failed to prevent postoperative delirium: Implications for future protocols. Neuroscience Letters. CLARE: Elsevier, 2023, roč. 798, February 20213, s. 1-4. ISSN 0304-3940. Dostupné z: https://dx.doi.org/10.1016/j.neulet.2023.137095. |
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@article{2375839, author = {Horacek, Jiri and Janda, Robert and Görnerova, Natalie and Jajcay, Lucia and Andrashko, Veronika}, article_location = {CLARE}, article_number = {February 20213}, doi = {http://dx.doi.org/10.1016/j.neulet.2023.137095}, keywords = {Ketamine; Postoperative delirium; Anesthesia; Neuroprotective; Neuroplastic; Benzodiazepines; Pharmacological interaction}, language = {eng}, issn = {0304-3940}, journal = {Neuroscience Letters}, title = {Several reasons why ketamine as a neuroplastic agent may have failed to prevent postoperative delirium: Implications for future protocols}, url = {https://www.sciencedirect.com/science/article/pii/S0304394023000496?via%3Dihub}, volume = {798}, year = {2023} }
TY - JOUR ID - 2375839 AU - Horacek, Jiri - Janda, Robert - Görnerova, Natalie - Jajcay, Lucia - Andrashko, Veronika PY - 2023 TI - Several reasons why ketamine as a neuroplastic agent may have failed to prevent postoperative delirium: Implications for future protocols JF - Neuroscience Letters VL - 798 IS - February 20213 SP - 1-4 EP - 1-4 PB - Elsevier SN - 03043940 KW - Ketamine KW - Postoperative delirium KW - Anesthesia KW - Neuroprotective KW - Neuroplastic KW - Benzodiazepines KW - Pharmacological interaction UR - https://www.sciencedirect.com/science/article/pii/S0304394023000496?via%3Dihub N2 - Ketamine exerts anti-inflammatory, neuroprotective and neuroplastic activity, therefore it may counteract the neurotoxic processes underlying postoperative delirium. However, the majority of studies in this field failed. We identified several pharmacological reasons why these studies may have failed, together with suggestions of how to remediate them. Among them, the interaction with intravenous general anesthetics exerting the opposite effect on GABA interneurons than ketamine may be of principal importance. We suggest biomarkers which may elucidate the influence of this interaction on the different steps of neuroplastic pathways. We hypothesize that administering ketamine before or after general anesthesia could both prevent the interactions and strengthen the effect of ketamine by timing surgery within the climax of ketamine-induced neuroplastic changes or by stabilizing AMPA receptors. It is vital to deal with these questions because the protocols of ongoing studies are based again on the administration of ketamine during general anesthesia (the major identified pitfall). ER -
HORACEK, Jiri, Robert JANDA, Natalie GÖRNEROVA, Lucia JAJCAY a Veronika ANDRASHKO. Several reasons why ketamine as a neuroplastic agent may have failed to prevent postoperative delirium: Implications for future protocols. \textit{Neuroscience Letters}. CLARE: Elsevier, 2023, roč.~798, February 20213, s.~1-4. ISSN~0304-3940. Dostupné z: https://dx.doi.org/10.1016/j.neulet.2023.137095.
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