Distance from main arteries influences microstructural and
functional brain tissue characteristics

J 2024

Distance from main arteries influences microstructural and functional brain tissue characteristics

WEISS, Viktor, Viktória KOKOŠOVÁ, Zdenek VALENTA, Irena DOLEŽALOVÁ, Marek BALÁŽ et. al.

Základní údaje

Originální název

Distance from main arteries influences microstructural and functional brain tissue characteristics

Autoři

WEISS, Viktor (203 Česká republika, domácí), Viktória KOKOŠOVÁ (703 Slovensko, domácí), Zdenek VALENTA (203 Česká republika), Irena DOLEŽALOVÁ (203 Česká republika, domácí), Marek BALÁŽ (703 Slovensko, domácí), Silvia MANGIA, Shalom MICHAELI, Lubomír VOJTÍŠEK (203 Česká republika, domácí), Igor NESTRASIL (203 Česká republika), Roman HERZIG (203 Česká republika) a Pavel FILIP (703 Slovensko, garant)

Vydání

Neuroimage, San Diego, ACADEMIC PRESS INC ELSEVIER SCIENCE, 2024, 1053-8119

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30210 Clinical neurology

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 5.700 v roce 2022

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1016/j.neuroimage.2023.120502

UT WoS

001139614000001

Klíčová slova anglicky

Quantitative MRI; Relaxometry; Diffusion weighted imaging; Resting -state functional MRI; Arterial distance

Štítky

14110127, 14110221, CF MAFIL, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 9. 3. 2024 14:52, Mgr. Eva Dubská

Anotace

V originále

Given the substantial dependence of neurons on continuous supply of energy, the distribution of major cerebral arteries opens a question whether the distance from the main supply arteries constitutes a modulating factor for the microstructural and functional properties of brain tissue. To tackle this question, multimodal MRI acquisitions of 102 healthy volunteers over the full adult age span were utilised. Relaxation along a fictitious field in the rotating frame of rank n = 4 (RAFF4), adiabatic T1p, T2p, and intracellular volume fraction (fICVF) derived from diffusion-weighted imaging were implemented to quantify microstructural (cellularity, myelin density, iron concentration) tissue characteristics and degree centrality and fractional amplitude of low-frequency fluctuations to probe for functional metrics. Inverse correlation of arterial distance with robust homogeneity was detected for T1p, T2p and RAFF4 for cortical grey matter and white matter, showing substantial complex microstructural differences between brain tissue close and farther from main arterial trunks. Albeit with wider variability, functional metrics pointed to increased connectivity and neuronal activity in areas farther from main arteries. Surprisingly, multiple of these microstructural and functional distance-based gradients diminished with higher age, pointing to uniformization of brain tissue with ageing. All in all, this pilot study provides a novel insight on brain regionalisation based on artery distance, which merits further investigation to validate its biological underpinnings.

Návaznosti

LM2018129, projekt VaV

Název: Národní infrastruktura pro biologické a medicínské zobrazování Czech-BioImaging

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, National research infrastructure for biological and medical imaging

Citovat

WEISS, Viktor, Viktória KOKOŠOVÁ, Zdenek VALENTA, Irena DOLEŽALOVÁ, Marek BALÁŽ, Silvia MANGIA, Shalom MICHAELI, Lubomír VOJTÍŠEK, Igor NESTRASIL, Roman HERZIG a Pavel FILIP. Distance from main arteries influences microstructural and functional brain tissue characteristics. Neuroimage. San Diego: ACADEMIC PRESS INC ELSEVIER SCIENCE, 2024, roč. 285, January 2024, s. 1-7. ISSN 1053-8119. Dostupné z: https://dx.doi.org/10.1016/j.neuroimage.2023.120502.

@article{2375897,
   author = {Weiss, Viktor and Kokošová, Viktória and Valenta, Zdenek and Doležalová, Irena and Baláž, Marek and Mangia, Silvia and Michaeli, Shalom and Vojtíšek, Lubomír and Nestrasil, Igor and Herzig, Roman and Filip, Pavel},
   article_location = {San Diego},
   article_number = {January 2024},
   doi = {http://dx.doi.org/10.1016/j.neuroimage.2023.120502},
   keywords = {Quantitative MRI; Relaxometry; Diffusion weighted imaging; Resting -state functional MRI; Arterial distance},
   language = {eng},
   issn = {1053-8119},
   journal = {Neuroimage},
   title = {Distance from main arteries influences microstructural and functional brain tissue characteristics},
   url = {https://www.sciencedirect.com/science/article/pii/S1053811923006523?via%3Dihub},
   volume = {285},
   year = {2024}
}

TY  - JOUR
ID  - 2375897
AU  - Weiss, Viktor - Kokošová, Viktória - Valenta, Zdenek - Doležalová, Irena - Baláž, Marek - Mangia, Silvia - Michaeli, Shalom - Vojtíšek, Lubomír - Nestrasil, Igor - Herzig, Roman - Filip, Pavel
PY  - 2024
TI  - Distance from main arteries influences microstructural and functional brain tissue characteristics
JF  - Neuroimage
VL  - 285
IS  - January 2024
SP  - 1-7
EP  - 1-7
PB  - ACADEMIC PRESS INC ELSEVIER SCIENCE
SN  - 10538119
KW  - Quantitative MRI
KW  - Relaxometry
KW  - Diffusion weighted imaging
KW  - Resting -state functional MRI
KW  - Arterial distance
UR  - https://www.sciencedirect.com/science/article/pii/S1053811923006523?via%3Dihub
N2  - Given the substantial dependence of neurons on continuous supply of energy, the distribution of major cerebral arteries opens a question whether the distance from the main supply arteries constitutes a modulating factor for the microstructural and functional properties of brain tissue. To tackle this question, multimodal MRI acquisitions of 102 healthy volunteers over the full adult age span were utilised. Relaxation along a fictitious field in the rotating frame of rank n = 4 (RAFF4), adiabatic T1p, T2p, and intracellular volume fraction (fICVF) derived from diffusion-weighted imaging were implemented to quantify microstructural (cellularity, myelin density, iron concentration) tissue characteristics and degree centrality and fractional amplitude of low-frequency fluctuations to probe for functional metrics. Inverse correlation of arterial distance with robust homogeneity was detected for T1p, T2p and RAFF4 for cortical grey matter and white matter, showing substantial complex microstructural differences between brain tissue close and farther from main arterial trunks. Albeit with wider variability, functional metrics pointed to increased connectivity and neuronal activity in areas farther from main arteries. Surprisingly, multiple of these microstructural and functional distance-based gradients diminished with higher age, pointing to uniformization of brain tissue with ageing. All in all, this pilot study provides a novel insight on brain regionalisation based on artery distance, which merits further investigation to validate its biological underpinnings.
ER  -

WEISS, Viktor, Viktória KOKOŠOVÁ, Zdenek VALENTA, Irena DOLEŽALOVÁ, Marek BALÁŽ, Silvia MANGIA, Shalom MICHAELI, Lubomír VOJTÍŠEK, Igor NESTRASIL, Roman HERZIG a Pavel FILIP. Distance from main arteries influences microstructural and functional brain tissue characteristics. \textit{Neuroimage}. San Diego: ACADEMIC PRESS INC ELSEVIER SCIENCE, 2024, roč.~285, January 2024, s.~1-7. ISSN~1053-8119. Dostupné z: https://dx.doi.org/10.1016/j.neuroimage.2023.120502.

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