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@article{2379118,
author = {Kubíčková, Barbara and Martinková, Šárka and Bohačiaková, Dáša and Hilscherová, Klára},
article_location = {CLARE},
article_number = {January 2024},
doi = {http://dx.doi.org/10.1016/j.toxlet.2023.12.004},
keywords = {Developmental neurotoxicity; NSC; Retinoids; Differentiation; Anatoxin; Cyanotoxin},
language = {eng},
issn = {0378-4274},
journal = {Toxicology Letters},
title = {Cyanobacterial anatoxin-a does not induce in vitro developmental neurotoxicity, but changes gene expression patterns in co-exposure with all-trans retinoic acid},
url = {https://www.sciencedirect.com/science/article/pii/S0378427423011116?via%3Dihub},
volume = {391},
year = {2024}
}
TY - JOUR
ID - 2379118
AU - Kubíčková, Barbara - Martinková, Šárka - Bohačiaková, Dáša - Hilscherová, Klára
PY - 2024
TI - Cyanobacterial anatoxin-a does not induce in vitro developmental neurotoxicity, but changes gene expression patterns in co-exposure with all-trans retinoic acid
JF - Toxicology Letters
VL - 391
IS - January 2024
SP - 39-44
EP - 39-44
PB - Elsevier
SN - 03784274
KW - Developmental neurotoxicity
KW - NSC
KW - Retinoids
KW - Differentiation
KW - Anatoxin
KW - Cyanotoxin
UR - https://www.sciencedirect.com/science/article/pii/S0378427423011116?via%3Dihub
N2 - Cyanobacterial blooms are increasing in frequency and intensity globally, and impacting recreational waters as well as waters used for drinking water provisioning. They are sources of bioactive metabolites including retinoids and the neurotoxin anatoxin-a. Here, we investigated the effects of anatoxin-a on a differentiating in vitro human neural stem cell model previously characterised with retinoic acids. Effects on protein and gene expression upon exposure for 9 or 18 days to anatoxin-a alone or in co-exposure with all-trans retinoic acid were evaluated using a panel of neural and glial differentiation biomarkers. Anatoxin-a did not cause distinct developmental neuro-toxicity alone, or in co-exposure with retinoic acid. However, in line with its excitotoxicity, in co-exposure with 200 nM all-trans retinoic acid it reduced the differentiation of acetylcholinergic neuron subtypes in the culture at 1000 nM (highest tested concentration). While this could have substantial functional implications for the developing nervous system, there is no indication for developmental neurotoxicity beyond its (excito-)toxicity to acetylcholinergic neurons, which only occurred in co-exposure to all-trans retinoic acid.
ER -
KUBÍČKOVÁ, Barbara, Šárka MARTINKOVÁ, Dáša BOHAČIAKOVÁ a Klára HILSCHEROVÁ. Cyanobacterial anatoxin-a does not induce in vitro developmental neurotoxicity, but changes gene expression patterns in co-exposure with all-trans retinoic acid. \textit{Toxicology Letters}. CLARE: Elsevier, 2024, roč.~391, January 2024, s.~39-44. ISSN~0378-4274. Dostupné z: https://dx.doi.org/10.1016/j.toxlet.2023.12.004.
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