Examining the association between posttraumatic stress disorder
and disruptions in cortical networks identified using
data-driven methods

J 2024

Examining the association between posttraumatic stress disorder and disruptions in cortical networks identified using data-driven methods

YANG, Jin, Ashley A HUGGINS, Delin SUN, C Lexi BAIRD, Courtney C HASWELL et. al.

Základní údaje

Originální název

Examining the association between posttraumatic stress disorder and disruptions in cortical networks identified using data-driven methods

Autoři

YANG, Jin, Ashley A HUGGINS, Delin SUN, C Lexi BAIRD, Courtney C HASWELL, Jessie L FRIJLING, Miranda OLFF, van Zuiden MIRJAM, Saskia B J KOCH, Laura NAWIJN, Dick J VELTMAN, Benjamin SUAREZ-JIMENEZ, Xi ZHU, Yuval NERIA, Anna R HUDSON, Sven C MUELLER, Justin T BAKER, Lauren A M LEBOIS, Milissa L KAUFMAN, Rongfeng QI, Guang Ming LU, Pavel ŘÍHA (203 Česká republika, domácí), Ivan REKTOR (203 Česká republika, domácí), Emily L DENNIS, Christopher R K CHING, Sophia I THOMOPOULOS, Lauren E SALMINEN, Neda JAHANSHAD, Paul M THOMPSON, Dan J STEIN, Sheri M KOOPOWITZ, Jonathan C IPSER, Soraya SEEDAT, du Plessis STEFAN, Leigh L VAN DEN HEUVEL, Li WANG, Ye ZHU, Gen LI, Anika SIERK, Antje MANTHEY, Henrik WALTER, Judith K DANIELS, Christian SCHMAHL, Julia I HERZOG, Israel LIBERZON, Anthony KING, Mike ANGSTADT, Nicholas D DAVENPORT, Scott R SPONHEIM, Seth G DISNER, Thomas STRAUBE, David HOFMANN, Daniel W GRUPE, Jack B NITSCHKE, Richard J DAVIDSON, Christine L LARSON, Terri A DEROON-CASSINI, Jennifer U BLACKFORD, Bunmi O OLATUNJI, Evan M GORDON, Geoffrey MAY, Steven M NELSON, Chadi G ABDALLAH, Ifat LEVY, Ilan HARPAZ-ROTEM, John H KRYSTAL, Rajendra A MOREY (garant) a Aristeidis SOTIRAS

Vydání

Neuropsychopharmacology, London, SPRINGERNATURE, 2024, 0893-133X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30210 Clinical neurology

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 7.600 v roce 2022

Organizační jednotka

Středoevropský technologický institut

DOI

http://dx.doi.org/10.1038/s41386-023-01763-5

UT WoS

001123265200001

Klíčová slova anglicky

posttraumatic stress disorder; disruptions; cortical networks

Štítky

14110127, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 28. 3. 2024 11:18, Mgr. Eva Dubská

Anotace

V originále

Posttraumatic stress disorder (PTSD) is associated with lower cortical thickness (CT) in prefrontal, cingulate, and insular cortices in diverse trauma-affected samples. However, some studies have failed to detect differences between PTSD patients and healthy controls or reported that PTSD is associated with greater CT. Using data-driven dimensionality reduction, we sought to conduct a well-powered study to identify vulnerable networks without regard to neuroanatomic boundaries. Moreover, this approach enabled us to avoid the excessive burden of multiple comparison correction that plagues vertex-wise methods. We derived structural covariance networks (SCNs) by applying non-negative matrix factorization (NMF) to CT data from 961 PTSD patients and 1124 trauma-exposed controls without PTSD. We used regression analyses to investigate associations between CT within SCNs and PTSD diagnosis (with and without accounting for the potential confounding effect of trauma type) and symptom severity in the full sample. We performed additional regression analyses in subsets of the data to examine associations between SCNs and comorbid depression, childhood trauma severity, and alcohol abuse. NMF identified 20 unbiased SCNs, which aligned closely with functionally defined brain networks. PTSD diagnosis was most strongly associated with diminished CT in SCNs that encompassed the bilateral superior frontal cortex, motor cortex, insular cortex, orbitofrontal cortex, medial occipital cortex, anterior cingulate cortex, and posterior cingulate cortex. CT in these networks was significantly negatively correlated with PTSD symptom severity. Collectively, these findings suggest that PTSD diagnosis is associated with widespread reductions in CT, particularly within prefrontal regulatory regions and broader emotion and sensory processing cortical regions.

Návaznosti

NV18-04-00559, projekt VaV

Název: Neurobiologické a psychologické markery reakce na extrémní stres a jeho dopad na potomky - třígenerační studie přeživších holokaust a jejich potomků

Investor: Ministerstvo zdravotnictví ČR, Neurobiologické a psychologické markery reakce na extrémní stres a dopad na generace potomků - třígenerační studie přeživších holokaust a jejich potomků

Citovat

YANG, Jin, Ashley A HUGGINS, Delin SUN, C Lexi BAIRD, Courtney C HASWELL, Jessie L FRIJLING, Miranda OLFF, van Zuiden MIRJAM, Saskia B J KOCH, Laura NAWIJN, Dick J VELTMAN, Benjamin SUAREZ-JIMENEZ, Xi ZHU, Yuval NERIA, Anna R HUDSON, Sven C MUELLER, Justin T BAKER, Lauren A M LEBOIS, Milissa L KAUFMAN, Rongfeng QI, Guang Ming LU, Pavel ŘÍHA, Ivan REKTOR, Emily L DENNIS, Christopher R K CHING, Sophia I THOMOPOULOS, Lauren E SALMINEN, Neda JAHANSHAD, Paul M THOMPSON, Dan J STEIN, Sheri M KOOPOWITZ, Jonathan C IPSER, Soraya SEEDAT, du Plessis STEFAN, Leigh L VAN DEN HEUVEL, Li WANG, Ye ZHU, Gen LI, Anika SIERK, Antje MANTHEY, Henrik WALTER, Judith K DANIELS, Christian SCHMAHL, Julia I HERZOG, Israel LIBERZON, Anthony KING, Mike ANGSTADT, Nicholas D DAVENPORT, Scott R SPONHEIM, Seth G DISNER, Thomas STRAUBE, David HOFMANN, Daniel W GRUPE, Jack B NITSCHKE, Richard J DAVIDSON, Christine L LARSON, Terri A DEROON-CASSINI, Jennifer U BLACKFORD, Bunmi O OLATUNJI, Evan M GORDON, Geoffrey MAY, Steven M NELSON, Chadi G ABDALLAH, Ifat LEVY, Ilan HARPAZ-ROTEM, John H KRYSTAL, Rajendra A MOREY a Aristeidis SOTIRAS. Examining the association between posttraumatic stress disorder and disruptions in cortical networks identified using data-driven methods. Neuropsychopharmacology. London: SPRINGERNATURE, 2024, roč. 49, č. 3, s. 609-619. ISSN 0893-133X. Dostupné z: https://dx.doi.org/10.1038/s41386-023-01763-5.

@article{2379563,
   author = {Yang, Jin and Huggins, Ashley A and Sun, Delin and Baird, C Lexi and Haswell, Courtney C and Frijling, Jessie L and Olff, Miranda and Mirjam, van Zuiden and Koch, Saskia B J and Nawijn, Laura and Veltman, Dick J and SuarezandJimenez, Benjamin and Zhu, Xi and Neria, Yuval and Hudson, Anna R and Mueller, Sven C and Baker, Justin T and Lebois, Lauren A M and Kaufman, Milissa L and Qi, Rongfeng and Lu, Guang Ming and Říha, Pavel and Rektor, Ivan and Dennis, Emily L and Ching, Christopher R K and Thomopoulos, Sophia I and Salminen, Lauren E and Jahanshad, Neda and Thompson, Paul M and Stein, Dan J and Koopowitz, Sheri M and Ipser, Jonathan C and Seedat, Soraya and Stefan, du Plessis and van den Heuvel, Leigh L and Wang, Li and Zhu, Ye and Li, Gen and Sierk, Anika and Manthey, Antje and Walter, Henrik and Daniels, Judith K and Schmahl, Christian and Herzog, Julia I and Liberzon, Israel and King, Anthony and Angstadt, Mike and Davenport, Nicholas D and Sponheim, Scott R and Disner, Seth G and Straube, Thomas and Hofmann, David and Grupe, Daniel W and Nitschke, Jack B and Davidson, Richard J and Larson, Christine L and deRoonandCassini, Terri A and Blackford, Jennifer U and Olatunji, Bunmi O and Gordon, Evan M and May, Geoffrey and Nelson, Steven M and Abdallah, Chadi G and Levy, Ifat and HarpazandRotem, Ilan and Krystal, John H and Morey, Rajendra A and Sotiras, Aristeidis},
   article_location = {London},
   article_number = {3},
   doi = {http://dx.doi.org/10.1038/s41386-023-01763-5},
   keywords = {posttraumatic stress disorder; disruptions; cortical networks},
   language = {eng},
   issn = {0893-133X},
   journal = {Neuropsychopharmacology},
   title = {Examining the association between posttraumatic stress disorder and disruptions in cortical networks identified using data-driven methods},
   url = {https://www.nature.com/articles/s41386-023-01763-5},
   volume = {49},
   year = {2024}
}

TY  - JOUR
ID  - 2379563
AU  - Yang, Jin - Huggins, Ashley A - Sun, Delin - Baird, C Lexi - Haswell, Courtney C - Frijling, Jessie L - Olff, Miranda - Mirjam, van Zuiden - Koch, Saskia B J - Nawijn, Laura - Veltman, Dick J - Suarez-Jimenez, Benjamin - Zhu, Xi - Neria, Yuval - Hudson, Anna R - Mueller, Sven C - Baker, Justin T - Lebois, Lauren A M - Kaufman, Milissa L - Qi, Rongfeng - Lu, Guang Ming - Říha, Pavel - Rektor, Ivan - Dennis, Emily L - Ching, Christopher R K - Thomopoulos, Sophia I - Salminen, Lauren E - Jahanshad, Neda - Thompson, Paul M - Stein, Dan J - Koopowitz, Sheri M - Ipser, Jonathan C - Seedat, Soraya - Stefan, du Plessis - van den Heuvel, Leigh L - Wang, Li - Zhu, Ye - Li, Gen - Sierk, Anika - Manthey, Antje - Walter, Henrik - Daniels, Judith K - Schmahl, Christian - Herzog, Julia I - Liberzon, Israel - King, Anthony - Angstadt, Mike - Davenport, Nicholas D - Sponheim, Scott R - Disner, Seth G - Straube, Thomas - Hofmann, David - Grupe, Daniel W - Nitschke, Jack B - Davidson, Richard J - Larson, Christine L - deRoon-Cassini, Terri A - Blackford, Jennifer U - Olatunji, Bunmi O - Gordon, Evan M - May, Geoffrey - Nelson, Steven M - Abdallah, Chadi G - Levy, Ifat - Harpaz-Rotem, Ilan - Krystal, John H - Morey, Rajendra A - Sotiras, Aristeidis
PY  - 2024
TI  - Examining the association between posttraumatic stress disorder and disruptions in cortical networks identified using data-driven methods
JF  - Neuropsychopharmacology
VL  - 49
IS  - 3
SP  - 609-619
EP  - 609-619
PB  - SPRINGERNATURE
SN  - 0893133X
KW  - posttraumatic stress disorder
KW  - disruptions
KW  - cortical networks
UR  - https://www.nature.com/articles/s41386-023-01763-5
N2  - Posttraumatic stress disorder (PTSD) is associated with lower cortical thickness (CT) in prefrontal, cingulate, and insular cortices in diverse trauma-affected samples. However, some studies have failed to detect differences between PTSD patients and healthy controls or reported that PTSD is associated with greater CT. Using data-driven dimensionality reduction, we sought to conduct a well-powered study to identify vulnerable networks without regard to neuroanatomic boundaries. Moreover, this approach enabled us to avoid the excessive burden of multiple comparison correction that plagues vertex-wise methods. We derived structural covariance networks (SCNs) by applying non-negative matrix factorization (NMF) to CT data from 961 PTSD patients and 1124 trauma-exposed controls without PTSD. We used regression analyses to investigate associations between CT within SCNs and PTSD diagnosis (with and without accounting for the potential confounding effect of trauma type) and symptom severity in the full sample. We performed additional regression analyses in subsets of the data to examine associations between SCNs and comorbid depression, childhood trauma severity, and alcohol abuse. NMF identified 20 unbiased SCNs, which aligned closely with functionally defined brain networks. PTSD diagnosis was most strongly associated with diminished CT in SCNs that encompassed the bilateral superior frontal cortex, motor cortex, insular cortex, orbitofrontal cortex, medial occipital cortex, anterior cingulate cortex, and posterior cingulate cortex. CT in these networks was significantly negatively correlated with PTSD symptom severity. Collectively, these findings suggest that PTSD diagnosis is associated with widespread reductions in CT, particularly within prefrontal regulatory regions and broader emotion and sensory processing cortical regions.
ER  -

YANG, Jin, Ashley A HUGGINS, Delin SUN, C Lexi BAIRD, Courtney C HASWELL, Jessie L FRIJLING, Miranda OLFF, van Zuiden MIRJAM, Saskia B J KOCH, Laura NAWIJN, Dick J VELTMAN, Benjamin SUAREZ-JIMENEZ, Xi ZHU, Yuval NERIA, Anna R HUDSON, Sven C MUELLER, Justin T BAKER, Lauren A M LEBOIS, Milissa L KAUFMAN, Rongfeng QI, Guang Ming LU, Pavel ŘÍHA, Ivan REKTOR, Emily L DENNIS, Christopher R K CHING, Sophia I THOMOPOULOS, Lauren E SALMINEN, Neda JAHANSHAD, Paul M THOMPSON, Dan J STEIN, Sheri M KOOPOWITZ, Jonathan C IPSER, Soraya SEEDAT, du Plessis STEFAN, Leigh L VAN DEN HEUVEL, Li WANG, Ye ZHU, Gen LI, Anika SIERK, Antje MANTHEY, Henrik WALTER, Judith K DANIELS, Christian SCHMAHL, Julia I HERZOG, Israel LIBERZON, Anthony KING, Mike ANGSTADT, Nicholas D DAVENPORT, Scott R SPONHEIM, Seth G DISNER, Thomas STRAUBE, David HOFMANN, Daniel W GRUPE, Jack B NITSCHKE, Richard J DAVIDSON, Christine L LARSON, Terri A DEROON-CASSINI, Jennifer U BLACKFORD, Bunmi O OLATUNJI, Evan M GORDON, Geoffrey MAY, Steven M NELSON, Chadi G ABDALLAH, Ifat LEVY, Ilan HARPAZ-ROTEM, John H KRYSTAL, Rajendra A MOREY a Aristeidis SOTIRAS. Examining the association between posttraumatic stress disorder and disruptions in cortical networks identified using data-driven methods. \textit{Neuropsychopharmacology}. London: SPRINGERNATURE, 2024, roč.~49, č.~3, s.~609-619. ISSN~0893-133X. Dostupné z: https://dx.doi.org/10.1038/s41386-023-01763-5.

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