Metabolic profiling of silymarin constituents in urine and
feces of healthy volunteers: A 90-day study

J 2023

Metabolic profiling of silymarin constituents in urine and feces of healthy volunteers: A 90-day study

LNENICKOVA, Katerina; Jiri VRBA; Pavel KOSINA; Barbora PAPOUSKOVA; Chahrazed MEKADIM et al.

Základní údaje

Originální název

Metabolic profiling of silymarin constituents in urine and feces of healthy volunteers: A 90-day study

Autoři

Vydání

Journal of Functional Foods, AMSTERDAM, Elsevier Ltd. 2023, 1756-4646

Další údaje

Typ výsledku

Článek v odborném periodiku

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 3.800

Označené pro přenos do RIV

DOI

https://doi.org/10.1016/j.jff.2022.105391

UT WoS

000916888400001

Klíčová slova anglicky

Flavonolignans; Silybin; Taxifolin; Human metabolites; Mass spectrometry; Fecal microbiota

Změněno: 13. 3. 2024 08:14, Mgr. Tereza Miškechová

Anotace

V originále

This study examined the metabolism of flavonolignans and taxifolin in 33 healthy adult male volunteers, who received 200 mg of silymarin orally twice daily for three months. First-morning urine and feces collected on days 10 and 90 were analyzed by UHPLC-MS and bacterial composition of feces was investigated by Next Generation Sequencing. The analyses revealed 5/4 types of flavonolignan/taxifolin metabolites in urine and 13/10 types of metabolites in feces, with large differences in total metabolite levels in both urine and feces observed among individual participants. In urine, 21 and 23 participants showed some increase in the total amount of flavonolignan and taxifolin metabolites, respectively, on day 90 compared with day 10. In feces, some correlation was found between the amount of metabolites and the composition of the intestinal microbiota. In conclusion, silymarin flavonolignans and taxifolin undergo multiple biotransformation reactions, and the metabolic profiles of the constituents considerably vary among individuals.

Citovat

LNENICKOVA, Katerina; Jiri VRBA; Pavel KOSINA; Barbora PAPOUSKOVA; Chahrazed MEKADIM; Jakub MRAZEK; Milan SOVA; Eliska SOVOVA; Katerina VALENTOVA; Vladimir KREN; Pavla KOURILOVA; Jana VRBKOVA a Jitka ULRICHOVA. Metabolic profiling of silymarin constituents in urine and feces of healthy volunteers: A 90-day study. Journal of Functional Foods. AMSTERDAM: Elsevier Ltd., 2023, roč. 100, 16 s. ISSN 1756-4646. Dostupné z: https://doi.org/10.1016/j.jff.2022.105391.

@article{2383618,
   author = {Lnenickova, Katerina and Vrba, Jiri and Kosina, Pavel and Papouskova, Barbora and Mekadim, Chahrazed and Mrazek, Jakub and Sova, Milan and Sovova, Eliska and Valentova, Katerina and Kren, Vladimir and Kourilova, Pavla and Vrbkova, Jana and Ulrichova, Jitka},
   article_location = {AMSTERDAM},
   doi = {https://doi.org/10.1016/j.jff.2022.105391},
   keywords = {Flavonolignans; Silybin; Taxifolin; Human metabolites; Mass spectrometry; Fecal microbiota},
   issn = {1756-4646},
   journal = {Journal of Functional Foods},
   note = {Bez afiliace k MU.},
   title = {Metabolic profiling of silymarin constituents in urine and feces of healthy volunteers: A 90-day study},
   volume = {100},
   year = {2023}
}

TY  - JOUR
ID  - 2383618
AU  - Lnenickova, Katerina - Vrba, Jiri - Kosina, Pavel - Papouskova, Barbora - Mekadim, Chahrazed - Mrazek, Jakub - Sova, Milan - Sovova, Eliska - Valentova, Katerina - Kren, Vladimir - Kourilova, Pavla - Vrbkova, Jana - Ulrichova, Jitka
PY  - 2023
TI  - Metabolic profiling of silymarin constituents in urine and feces of healthy volunteers: A 90-day study
JF  - Journal of Functional Foods
VL  - 100
PB  - Elsevier Ltd.
SN  - 17564646
N1  - Bez afiliace k MU.
KW  - Flavonolignans
KW  - Silybin
KW  - Taxifolin
KW  - Human metabolites
KW  - Mass spectrometry
KW  - Fecal microbiota
N2  - This study examined the metabolism of flavonolignans and taxifolin in 33 healthy adult male volunteers, who received 200 mg of silymarin orally twice daily for three months. First-morning urine and feces collected on days 10 and 90 were analyzed by UHPLC-MS and bacterial composition of feces was investigated by Next Generation Sequencing. The analyses revealed 5/4 types of flavonolignan/taxifolin metabolites in urine and 13/10 types of metabolites in feces, with large differences in total metabolite levels in both urine and feces observed among individual participants. In urine, 21 and 23 participants showed some increase in the total amount of flavonolignan and taxifolin metabolites, respectively, on day 90 compared with day 10. In feces, some correlation was found between the amount of metabolites and the composition of the intestinal microbiota. In conclusion, silymarin flavonolignans and taxifolin undergo multiple biotransformation reactions, and the metabolic profiles of the constituents considerably vary among individuals.
ER  -

LNENICKOVA, Katerina; Jiri VRBA; Pavel KOSINA; Barbora PAPOUSKOVA; Chahrazed MEKADIM; Jakub MRAZEK; Milan SOVA; Eliska SOVOVA; Katerina VALENTOVA; Vladimir KREN; Pavla KOURILOVA; Jana VRBKOVA a Jitka ULRICHOVA. Metabolic profiling of silymarin constituents in urine and feces of healthy volunteers: A 90-day study. \textit{Journal of Functional Foods}. AMSTERDAM: Elsevier Ltd., 2023, roč.~100, 16 s. ISSN~1756-4646. Dostupné z: https://doi.org/10.1016/j.jff.2022.105391.

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