Supported polymer/lipid hybrid bilayers formation resembles a
lipid-like dynamic by reducing the molecular weight of the
polymer

J 2021

Supported polymer/lipid hybrid bilayers formation resembles a lipid-like dynamic by reducing the molecular weight of the polymer

BELLO, Gianluca, Francesca CAVALLINI, Lea Ann DAILEY a Eva-Kathrin EHMOSER

Základní údaje

Originální název

Supported polymer/lipid hybrid bilayers formation resembles a lipid-like dynamic by reducing the molecular weight of the polymer

Autoři

BELLO, Gianluca (garant), Francesca CAVALLINI, Lea Ann DAILEY a Eva-Kathrin EHMOSER

Vydání

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, AMSTERDAM, ELSEVIER SCIENCE BV, 2021, 0005-2736

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10608 Biochemistry and molecular biology

Stát vydavatele

Nizozemské království

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.019

Kód RIV

RIV/00216224:90127/21:00133782

Organizační jednotka

CIISB II

DOI

http://dx.doi.org/10.1016/j.bbamem.2020.183472

UT WoS

000594121100015

Klíčová slova anglicky

Supported bilayer; QCM-D; SANS; Hybrid lipid-polymer bilayer; Langmuir films; Amphiphilic copolymer

Štítky

CF CRYO, ne MU, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 12. 4. 2024 13:04, Mgr. Michal Petr

Anotace

V originále

Amphiphilic block copolymers form self-assembled bilayers even in combination with phospholipids. They represent an attractive alternative to native lipid-based membrane systems for supported bilayer formation with applications in biomedical research, sensoring and drug delivery. Their enhanced stability and excellent mechanical properties are linked to their higher molecular weight which generates thicker bilayers. Hypothesis: It is hypothesized that reducing the molecular weight of the polymer facilitates the formation of a thinner, more homogeneous polymer/lipid hybrid bilayer which would benefit the formation of supported bilayers on silicon oxide. Experiment: We investigated hybrid bilayers composed of mixtures of 1-palmitoyl-2-oleoyl-glycero-3-phosphocholine and increasing amounts of a low molecular weight polybutadiene-b-polyethylene oxide copolymer (1050 g/mol). By assessing the bilayer thickness and the molecular packing behavior we sought to demonstrate how reducing the polymer molecular weight increases the tendency to form supported hybrid bilayers in a lipid-like manner. Findings: The formation of a supported hybrid bilayers occurs at polymer contents < 70 mol% in a lipid-like fashion and is proportional to the cohesive forces between the bilayer components and inversely related to the bilayer hydrophobic core thickness and the extended brush regime of the PEGylated polymeric headgroup.

Návaznosti

90127, velká výzkumná infrastruktura

Název: CIISB II

Citovat

BELLO, Gianluca, Francesca CAVALLINI, Lea Ann DAILEY a Eva-Kathrin EHMOSER. Supported polymer/lipid hybrid bilayers formation resembles a lipid-like dynamic by reducing the molecular weight of the polymer. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES. AMSTERDAM: ELSEVIER SCIENCE BV, 2021, roč. 1863, č. 1, s. 1-8. ISSN 0005-2736. Dostupné z: https://dx.doi.org/10.1016/j.bbamem.2020.183472.

@article{2384339,
   author = {Bello, Gianluca and Cavallini, Francesca and Dailey, Lea Ann and Ehmoser, EvaandKathrin},
   article_location = {AMSTERDAM},
   article_number = {1},
   doi = {http://dx.doi.org/10.1016/j.bbamem.2020.183472},
   keywords = {Supported bilayer; QCM-D; SANS; Hybrid lipid-polymer bilayer; Langmuir films; Amphiphilic copolymer},
   language = {eng},
   issn = {0005-2736},
   journal = {BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES},
   title = {Supported polymer/lipid hybrid bilayers formation resembles a lipid-like dynamic by reducing the molecular weight of the polymer},
   url = {https://www.sciencedirect.com/science/article/pii/S0005273620303151?via%3Dihub},
   volume = {1863},
   year = {2021}
}

TY  - JOUR
ID  - 2384339
AU  - Bello, Gianluca - Cavallini, Francesca - Dailey, Lea Ann - Ehmoser, Eva-Kathrin
PY  - 2021
TI  - Supported polymer/lipid hybrid bilayers formation resembles a lipid-like dynamic by reducing the molecular weight of the polymer
JF  - BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
VL  - 1863
IS  - 1
SP  - 1-8
EP  - 1-8
PB  - ELSEVIER SCIENCE BV
SN  - 00052736
KW  - Supported bilayer
KW  - QCM-D
KW  - SANS
KW  - Hybrid lipid-polymer bilayer
KW  - Langmuir films
KW  - Amphiphilic copolymer
UR  - https://www.sciencedirect.com/science/article/pii/S0005273620303151?via%3Dihub
N2  - Amphiphilic block copolymers form self-assembled bilayers even in combination with phospholipids. They represent an attractive alternative to native lipid-based membrane systems for supported bilayer formation with applications in biomedical research, sensoring and drug delivery. Their enhanced stability and excellent mechanical properties are linked to their higher molecular weight which generates thicker bilayers. Hypothesis: It is hypothesized that reducing the molecular weight of the polymer facilitates the formation of a thinner, more homogeneous polymer/lipid hybrid bilayer which would benefit the formation of supported bilayers on silicon oxide. Experiment: We investigated hybrid bilayers composed of mixtures of 1-palmitoyl-2-oleoyl-glycero-3-phosphocholine and increasing amounts of a low molecular weight polybutadiene-b-polyethylene oxide copolymer (1050 g/mol). By assessing the bilayer thickness and the molecular packing behavior we sought to demonstrate how reducing the polymer molecular weight increases the tendency to form supported hybrid bilayers in a lipid-like manner. Findings: The formation of a supported hybrid bilayers occurs at polymer contents < 70 mol% in a lipid-like fashion and is proportional to the cohesive forces between the bilayer components and inversely related to the bilayer hydrophobic core thickness and the extended brush regime of the PEGylated polymeric headgroup.
ER  -

BELLO, Gianluca, Francesca CAVALLINI, Lea Ann DAILEY a Eva-Kathrin EHMOSER. Supported polymer/lipid hybrid bilayers formation resembles a lipid-like dynamic by reducing the molecular weight of the polymer. \textit{BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES}. AMSTERDAM: ELSEVIER SCIENCE BV, 2021, roč.~1863, č.~1, s.~1-8. ISSN~0005-2736. Dostupné z: https://dx.doi.org/10.1016/j.bbamem.2020.183472.

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