POSSIBLE EFFECT OF OAS1 AND TMPRSS6 BUT NOT DPP4 AND ZNF335
POLYMORPHISMS ON COVID-19 SEVERITY IN THE CZECH POPULATION

J 2023

POSSIBLE EFFECT OF OAS1 AND TMPRSS6 BUT NOT DPP4 AND ZNF335 POLYMORPHISMS ON COVID-19 SEVERITY IN THE CZECH POPULATION

HUBACEK, Jaroslav A; Tom PHILIPP; Vera ADAMKOVA; Ondřej MÁJEK; Dana DLOUHA et al.

Základní údaje

Originální název

POSSIBLE EFFECT OF OAS1 AND TMPRSS6 BUT NOT DPP4 AND ZNF335 POLYMORPHISMS ON COVID-19 SEVERITY IN THE CZECH POPULATION

Autoři

HUBACEK, Jaroslav A; Tom PHILIPP; Vera ADAMKOVA; Ondřej MÁJEK ; Dana DLOUHA a Ladislav DUŠEK

Vydání

Central European journal of public health, Praha, Česká lékařská společnost J.E. Purkyně, 2023, 1210-7778

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30304 Public and environmental health

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 1.100

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/23:00133875

Organizační jednotka

Lékařská fakulta

DOI

https://doi.org/10.21101/cejph.a7906

UT WoS

001166654700002

EID Scopus

2-s2.0-85184113461

Klíčová slova anglicky

COVID-19; DPP4; OAS1; polymorphism; SARS-CoV-2; severity; TMPRSS6; ZNF335

Štítky

14119612, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 22. 3. 2024 09:34, Mgr. Tereza Miškechová

Anotace

V originále

Objectives: The acute respiratory syndrome, known as COVID-19, is characterised by high morbidity and increased mortality. Genetic factors may partially explain the differences in susceptibility to and severity of COVID-19. Methods: We have analysed common functional polymorphisms within the OAS1 (rs4767027), TMPRSS6 (rs855791), DPP4 (rs3788979), and ZNF335 (rs3848719) genes in SARS-CoV-2 positive subjects (n = 521, different disease severity) and in population controls (n = 2,559 subjects, COVID-19 status unknown). Results: Neither DPP4 nor ZNF335 were associated with disease susceptibility or severity in the Czech population in any of the models used for calculation. T allele carriers of the OAS1 polymorphism seem to be protective against symptomatic COVID-19 (p = 0.002 calculated for trend; asymptomatic, symptomatic, hospitalised). Similarly, within the TMPRSS6, minor TT homozygotes associated with lower plasma Fe concentrations were underrepresented in the overall patient group (p = 0.044; OR = 0.77, 95% CI: 0.59-0.99), and the difference was mainly driven by the severe COVID-19 subjects. In general, risky homozygotes of these two polymorphisms were less frequent than expected in the group of hospitalised COVID-19 survivors. Conclusions: Common variants within OAS1 (rs4767027) and TMPRSS6 (rs855791) play some role in COVID-19 pathology in the Czech Caucasian population. Whether the depletion of minor allele carriers of these two variants is associated with increased COVID-19 mortality, needs to be analysed in an external confirmatory study.

Citovat

HUBACEK, Jaroslav A; Tom PHILIPP; Vera ADAMKOVA; Ondřej MÁJEK; Dana DLOUHA a Ladislav DUŠEK. POSSIBLE EFFECT OF OAS1 AND TMPRSS6 BUT NOT DPP4 AND ZNF335 POLYMORPHISMS ON COVID-19 SEVERITY IN THE CZECH POPULATION. Central European journal of public health. Praha: Česká lékařská společnost J.E. Purkyně, 2023, roč. 31, č. 4, s. 235-239. ISSN 1210-7778. Dostupné z: https://doi.org/10.21101/cejph.a7906.

@article{2386697,
   author = {Hubacek, Jaroslav A and Philipp, Tom and Adamkova, Vera and Májek, Ondřej and Dlouha, Dana and Dušek, Ladislav},
   article_location = {Praha},
   article_number = {4},
   doi = {https://doi.org/10.21101/cejph.a7906},
   keywords = {COVID-19; DPP4; OAS1; polymorphism; SARS-CoV-2; severity; TMPRSS6; ZNF335},
   language = {eng},
   issn = {1210-7778},
   journal = {Central European journal of public health},
   title = {POSSIBLE EFFECT OF OAS1 AND TMPRSS6 BUT NOT DPP4 AND ZNF335 POLYMORPHISMS ON COVID-19 SEVERITY IN THE CZECH POPULATION},
   url = {https://cejph.szu.cz/artkey/cjp-202304-0002_possible-effect-of-oas1-and-tmprss6-but-not-dpp4-and-znf335-polymorphisms-on-covid-19-severity-in-the-czech-pop.php},
   volume = {31},
   year = {2023}
}

TY  - JOUR
ID  - 2386697
AU  - Hubacek, Jaroslav A - Philipp, Tom - Adamkova, Vera - Májek, Ondřej - Dlouha, Dana - Dušek, Ladislav
PY  - 2023
TI  - POSSIBLE EFFECT OF OAS1 AND TMPRSS6 BUT NOT DPP4 AND ZNF335 POLYMORPHISMS ON COVID-19 SEVERITY IN THE CZECH POPULATION
JF  - Central European journal of public health
VL  - 31
IS  - 4
SP  - 235-239
EP  - 235-239
PB  - Česká lékařská společnost J.E. Purkyně
SN  - 12107778
KW  - COVID-19
KW  - DPP4
KW  - OAS1
KW  - polymorphism
KW  - SARS-CoV-2
KW  - severity
KW  - TMPRSS6
KW  - ZNF335
UR  - https://cejph.szu.cz/artkey/cjp-202304-0002_possible-effect-of-oas1-and-tmprss6-but-not-dpp4-and-znf335-polymorphisms-on-covid-19-severity-in-the-czech-pop.php
N2  - Objectives: The acute respiratory syndrome, known as COVID-19, is characterised by high morbidity and increased mortality. Genetic factors may partially explain the differences in susceptibility to and severity of COVID-19. Methods: We have analysed common functional polymorphisms within the OAS1 (rs4767027), TMPRSS6 (rs855791), DPP4 (rs3788979), and ZNF335 (rs3848719) genes in SARS-CoV-2 positive subjects (n = 521, different disease severity) and in population controls (n = 2,559 subjects, COVID-19 status unknown). Results: Neither DPP4 nor ZNF335 were associated with disease susceptibility or severity in the Czech population in any of the models used for calculation. T allele carriers of the OAS1 polymorphism seem to be protective against symptomatic COVID-19 (p = 0.002 calculated for trend; asymptomatic, symptomatic, hospitalised). Similarly, within the TMPRSS6, minor TT homozygotes associated with lower plasma Fe concentrations were underrepresented in the overall patient group (p = 0.044; OR = 0.77, 95% CI: 0.59-0.99), and the difference was mainly driven by the severe COVID-19 subjects. In general, risky homozygotes of these two polymorphisms were less frequent than expected in the group of hospitalised COVID-19 survivors. Conclusions: Common variants within OAS1 (rs4767027) and TMPRSS6 (rs855791) play some role in COVID-19 pathology in the Czech Caucasian population. Whether the depletion of minor allele carriers of these two variants is associated with increased COVID-19 mortality, needs to be analysed in an external confirmatory study.
ER  -

HUBACEK, Jaroslav A; Tom PHILIPP; Vera ADAMKOVA; Ondřej MÁJEK; Dana DLOUHA a Ladislav DUŠEK. POSSIBLE EFFECT OF OAS1 AND TMPRSS6 BUT NOT DPP4 AND ZNF335 POLYMORPHISMS ON COVID-19 SEVERITY IN THE CZECH POPULATION. \textit{Central European journal of public health}. Praha: Česká lékařská společnost J.E. Purkyně, 2023, roč.~31, č.~4, s.~235-239. ISSN~1210-7778. Dostupné z: https://doi.org/10.21101/cejph.a7906.

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